Volume 9(5); 2021 Oct

Original Article

Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damage

Kuilong Wang, Xiaofen Xu, Aikebaier Maimaiti, Min Hao, Xianan Sang, Qiyuan Shan, Xin Wu, Gang Cao

Pharmacol Res Perspect. 2021 Oct; 9(5): e00765. Published online 2021 Sep 14. doi: 10.1002/prp2.765

PMCID:: PMC8440943

Article PDF–2.5M

Research Highlights from South America

Invited Reviews

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

María de la Paz Sarasola, Mónica A. Táquez Delgado, Melisa B. Nicoud, Vanina A. Medina

Pharmacol Res Perspect. 2021 Oct; 9(5): e00778. Published online 2021 Oct 5. doi: 10.1002/prp2.778

PMCID:: PMC8491460

Article PDF–2.3M

Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract

María Elena Fátima Nader‐Macías, Priscilla Romina De Gregorio, Jessica Alejandra Silva

Pharmacol Res Perspect. 2021 Oct; 9(5): e00787. Published online 2021 Oct 5. doi: 10.1002/prp2.787

PMCID:: PMC8491456

Article PDF–1.8M

Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders

María Laura Palumbo, Alejandro David Moroni, Sofía Quiroga, María Micaela Castro, Adriana Laura Burgueño, Ana María Genaro

Pharmacol Res Perspect. 2021 Oct; 9(5): e00795. Published online 2021 Oct 5. doi: 10.1002/prp2.795

PMCID:: PMC8491457

Article PDF–1.4M

Original Article

Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study

Andrea Pasta, Paolo Borro, Anna Laura Cremonini, Elena Formisano, Giulia Tozzi, Stefano Cecchi, Raffaele Fresa, Sara Labanca, Afscin Djahandideh, Samir Giuseppe Sukkar, Antonino Picciotto, Livia Pisciotta

Pharmacol Res Perspect. 2021 Oct; 9(5): e00820. Published online 2021 Sep 2. doi: 10.1002/prp2.820

PMCID:: PMC8413903

Article PDF–815K

Research Highlights from South America

Invited Review

The use of GA‐RxODE (Genetics Algorithms and Running simulations from Ordinary Differential Equations‐based model) method to optimize bioequivalence studies

Ezequiel Omar Nuske, Mikhail Morozov, Héctor Alejandro Serra

Pharmacol Res Perspect. 2021 Oct; 9(5): e00824. Published online 2021 Oct 5. doi: 10.1002/prp2.824

PMCID:: PMC8491459

Article PDF–1.0M

Original Articles

Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8

Andreas Port, Jamie V. Shaw, Lena Klopp‐Schulze, Afrim Bytyqi, Claudia Vetter, Elizabeth Hussey, Nadra Mammasse, Victor Ona, Angelika Bachmann, Denis Strugala, Christian Reh, Kosalaram Goteti

Pharmacol Res Perspect. 2021 Oct; 9(5): e00842. Published online 2021 Aug 19. doi: 10.1002/prp2.842

PMCID:: PMC8377444

Article PDF–1.0M

Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis

Elodie Charuel, Thibault Menini, Sabrina Bedhomme, Bruno Pereira, Nathalie Piñol‐Domenech, Suzy Bouchant, Rémy Boussageon, Sylvaine Bœuf‐Gibot, Helene Vaillant‐Roussel

Pharmacol Res Perspect. 2021 Oct; 9(5): e00844. Published online 2021 Oct 7. doi: 10.1002/prp2.844

PMCID:: PMC8495680

Article PDF–1.4M

An exploratory first‐in‐man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2‐ and 1‐week interval in patients with metastatic castration resistant prostate cancer

Josephina P. M. Vrouwe, Ingrid M. C. Kamerling, Michiel J. van Esdonk, Josbert M. Metselaar, Frederik E. Stuurman, Gabri van der Pluijm, Jacobus Burggraaf, Susanne Osanto

Pharmacol Res Perspect. 2021 Oct; 9(5): e00845. Published online 2021 Aug 20. doi: 10.1002/prp2.845

PMCID:: PMC8377443

Article PDF–1.0M

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo

Pharmacol Res Perspect. 2021 Oct; 9(5): e00846. Published online 2021 Oct 8. doi: 10.1002/prp2.846

PMCID:: PMC8500343

Article PDF–746K

Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants

Georges Vauquelin, Dominique Maes

Pharmacol Res Perspect. 2021 Oct; 9(5): e00847. Published online 2021 Aug 30. doi: 10.1002/prp2.847

PMCID:: PMC8404059

Article PDF–1.8M

Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population‐based assessment

Ya‐Hui Yu, Kristian B. Filion, Pauline Reynier, Robert W. Platt, Oriana H. Y. Yu, Sonia M. Grandi

Pharmacol Res Perspect. 2021 Oct; 9(5): e00848. Published online 2021 Aug 13. doi: 10.1002/prp2.848

PMCID:: PMC8363773

Article PDF–1019K

Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double‐blind, controlled trial

Tianxiao Liu, Ting Lai, Jing Chen, Yizhi Lu, Fang He, Yanhua Chen, Yubo Xie

Pharmacol Res Perspect. 2021 Oct; 9(5): e00851. Published online 2021 Aug 13. doi: 10.1002/prp2.851

PMCID:: PMC8363771

Article PDF–641K

[8]‐Gingerol exerts anti‐myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L‐type Ca²⁺ channels

Yucong Xue, Muqing Zhang, Bin Zheng, Yuanyuan Zhang, Xi Chu, Yu Liu, Ziliang Li, Xue Han, Li Chu

Pharmacol Res Perspect. 2021 Oct; 9(5): e00852. Published online 2021 Aug 14. doi: 10.1002/prp2.852

PMCID:: PMC8364294

Article PDF–2.1M

Pharmacology Education and Innovation Series

Original Article

Lumbriculus variegatus: A novel organism for in vivo pharmacology education

Aidan Seeley, Caitlin Bellamy, Nia A. Davies, Melisa J. Wallace

Pharmacol Res Perspect. 2021 Oct; 9(5): e00853. Published online 2021 Aug 20. doi: 10.1002/prp2.853

PMCID:: PMC8380063

Article PDF–1.6M

Original Articles

EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers

Raquel Luna Yolba, Virgile Visentin, Caroline Hervé, Johanna Chiche, Jean‐Ehrland Ricci, Jérôme Méneyrol, Michaël R. Paillasse, Nathalie Alet

Pharmacol Res Perspect. 2021 Oct; 9(5): e00854. Published online 2021 Sep 3. doi: 10.1002/prp2.854

PMCID:: PMC8415080

Article PDF–1.9M

Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol

Stéphane Krief, Isabelle Berrebi‐Bertrand, Isabelle Nagmar, Martin Giret, Simon Belliard, David Perrin, Marilyne Uguen, Philippe Robert, Jeanne‐Marie Lecomte, Jean‐Charles Schwartz, Olivier Finance, Xavier Ligneau

Pharmacol Res Perspect. 2021 Oct; 9(5): e00855. Published online 2021 Aug 23. doi: 10.1002/prp2.855

PMCID:: PMC8381683

Article PDF–1.1M

A pharmacokinetics‐based approach to the monitoring of patient adherence to atorvastatin therapy

Gellért Balázs Karvaly, István Karádi, István Vincze, Michael N. Neely, Eszter Trojnár, Zoltán Prohászka, Éva Imreh, Barna Vásárhelyi, András Zsáry

Pharmacol Res Perspect. 2021 Oct; 9(5): e00856. Published online 2021 Sep 3. doi: 10.1002/prp2.856

PMCID:: PMC8415218

Article PDF–1.3M

Recombinant botulinum neurotoxin serotype A1 in vivo characterization

Cindy Périer, Vincent Martin, Sylvie Cornet, Christine Favre‐Guilmard, Marie‐Noelle Rocher, Julien Bindler, Stéphanie Wagner, Emile Andriambeloson, Brian Rudkin, Rudy Marty, Alban Vignaud, Matthew Beard, Stephane Lezmi, Mikhail Kalinichev

Pharmacol Res Perspect. 2021 Oct; 9(5): e00857. Published online 2021 Oct 10. doi: 10.1002/prp2.857

PMCID:: PMC8502944

Article PDF–2.2M

A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

Blaise M. Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N. Bledsoe, Bryanna N. Vacca, Tullia V. Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G. Klein

Pharmacol Res Perspect. 2021 Oct; 9(5): e00859. Published online 2021 Sep 3. doi: 10.1002/prp2.859

PMCID:: PMC8413904

Article PDF–2.1M

Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification

Kata W. Pedersen, Jakob Hansen, Jørgen B. Hasselstrøm, Jakob R. Jornil

Pharmacol Res Perspect. 2021 Oct; 9(5): e00860. Published online 2021 Sep 3. doi: 10.1002/prp2.860

PMCID:: PMC8415216

Article PDF–1.1M

Review Article

A framework for economic evaluation of therapeutic drug monitoring—guided dosing in oncology

Daniel Erku, Jennifer Schneider, Paul Scuffham

Pharmacol Res Perspect. 2021 Oct; 9(5): e00862. Published online 2021 Sep 21. doi: 10.1002/prp2.862

PMCID:: PMC8453491

Article PDF–489K

Research Highlights from South America

Invited Review

Strategies to apply 3Rs in preclinical testing

Susana B. Gorzalczany, Angeles G. Rodriguez Basso

Pharmacol Res Perspect. 2021 Oct; 9(5): e00863. Published online 2021 Oct 5. doi: 10.1002/prp2.863

PMCID:: PMC8491455

Article PDF–625K

Original Articles

Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders

Julia Sagahón‐Azúa, Susanna Edith Medellín‐Garibay, Cinthya Eloisa Chávez‐Castillo, César Guillermo González‐Salinas, Rosa del Carmen Milán‐Segovia, Silvia Romano‐Moreno

Pharmacol Res Perspect. 2021 Oct; 9(5): e00864. Published online 2021 Sep 14. doi: 10.1002/prp2.864

PMCID:: PMC8441053

Article PDF–956K

Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions

Karan Matharu, Kiran Chana, Charles J. Ferro, Alan M. Jones

Pharmacol Res Perspect. 2021 Oct; 9(5): e00867. Published online 2021 Sep 29. doi: 10.1002/prp2.867

PMCID:: PMC8480305

Article PDF–808K

Research Highlights from South America

Editorial

South American special issue: Editorial

Federico Monczor, Ana Genaro

Pharmacol Res Perspect. 2021 Oct; 9(5): e00868. Published online 2021 Oct 5. doi: 10.1002/prp2.868

PMCID:: PMC8491458

Article PDF–187K

Original Articles

Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease

Nanae Ishida, Maki Saito, Sachiko Sato, Yu Tezuka, Atsushi Sanbe, Eiichi Taira, Masamichi Hirose

Pharmacol Res Perspect. 2021 Oct; 9(5): e00869. Published online 2021 Sep 29. doi: 10.1002/prp2.869

PMCID:: PMC8480397

Article PDF–2.4M

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease

Mohammad Sanaei‐Ardekani, Shyreen Kamal, Whitney Handy, Sidrah Alam, Aya Salaheldin, Anderson Moore, Shahrzad Movafagh

Pharmacol Res Perspect. 2021 Oct; 9(5): e00872. Published online 2021 Oct 7. doi: 10.1002/prp2.872

PMCID:: PMC8495681

Article PDF–1.7M

Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals

Luciana Boavista Barros Heil, Fernanda Ferreira Cruz, Mariana Alves Antunes, Cassia Lisboa Braga, Lais Costa Agra, Rebecca Madureira Bose Leão, Soraia Carvalho Abreu, Paolo Pelosi, Pedro Leme Silva, Patricia Rieken Macedo Rocco

Pharmacol Res Perspect. 2021 Oct; 9(5): e00873. Published online 2021 Oct 10. doi: 10.1002/prp2.873

PMCID:: PMC8503301

Article PDF–996K

Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Yuzo Horibuchi, Shuichi Iino, Shunji Matsuki, Yoichiro Ogama, Hiroyoshi Kakuyama

Pharmacol Res Perspect. 2021 Oct; 9(5): e00874. Published online 2021 Oct 10. doi: 10.1002/prp2.874

PMCID:: PMC8502439

Article PDF–803K

Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S‐3100‐CA, in mice

Kengo Sakurai, Tomohiro Kuroda, Jun Abe, Hiroshi Toda, Sachiko Kitamoto

Pharmacol Res Perspect. 2021 Oct; 9(5): e00877. Published online 2021 Oct 7. doi: 10.1002/prp2.877

PMCID:: PMC8496750

Article PDF–946K

Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats

Shuyao Wang, Chun Chen, Chi Guan, Liping Qiu, Lei Zhang, Shaofeng Zhang, Hongyu Zhou, Hongwen Du, Chen Li, Yaqiong Wu, Hang Chang, Tao Wang

Pharmacol Res Perspect. 2021 Oct; 9(5): e00879. Published online 2021 Oct 10. doi: 10.1002/prp2.879

PMCID:: PMC8502442

Article PDF–1012K

Corrigendum

Pharmacol Res Perspect. 2021 Oct; 9(5): e00858. Published online 2021 Sep 1. doi: 10.1002/prp2.858

Corrects:: Pharmacol Res Perspect. 2020 Feb; 8(1): e00554.

PMCID:: PMC8411038

Correction PDF–112K

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