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Volume 57(3);  2013 Mar

Minireview

N-Chloramines, a Promising Class of Well-Tolerated Topical Anti-Infectives
Waldemar Gottardi, Dmitri Debabov, Markus Nagl
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1107–1114. doi: 10.1128/AAC.02132-12
PMCID:
PMC3591902
Article PDF–287K

Chemistry; Biosynthesis

Function of Cytochrome P450 Enzymes RosC and RosD in the Biosynthesis of Rosamicin Macrolide Antibiotic Produced by Micromonospora rosaria
Yohei Iizaka, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, Moeka Takeda, Yojiro Anzai, Fumio Kato
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1529–1531. doi: 10.1128/AAC.02092-12
PMCID:
PMC3591866
Article PDF–352K

Mechanisms of Action: Physiological Effects

Apoptotic Marker Expression in the Absence of Cell Death in Staurosporine-Treated Leishmania donovani
Aude L. Foucher, Najma Rachidi, Sarah Gharbi, Thierry Blisnick, Philippe Bastin, Iain K. Pemberton, Gerald F. Späth
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1252–1261. doi: 10.1128/AAC.01983-12
PMCID:
PMC3591890
Article PDF–1.3M
In Vitro Interaction between Alginate Lyase and Amphotericin B against Aspergillus fumigatus Biofilm Determined by Different Methods
Francesca Bugli, Brunella Posteraro, Massimiliano Papi, Riccardo Torelli, Alessandro Maiorana, Francesco Paroni Sterbini, Patrizia Posteraro, Maurizio Sanguinetti, Marco De Spirito
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1275–1282. doi: 10.1128/AAC.01875-12
PMCID:
PMC3591909
Article PDF–1.6M
Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens
Andrew G. Warrilow, Josie E. Parker, Diane E. Kelly, Steven L. Kelly
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1352–1360. doi: 10.1128/AAC.02067-12
PMCID:
PMC3591892
Article PDF–2.5M
Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis
Carrie D. Fischer, Jennifer K. Beatty, Stephanie C. Duquette, Douglas W. Morck, Merlyn J. Lucas, André G. Buret
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1385–1393. doi: 10.1128/AAC.01598-12
PMCID:
PMC3591872
Article PDF–2.2M
Defining the Timing of Action of Antimalarial Drugs against Plasmodium falciparum
Danny W. Wilson, Christine Langer, Christopher D. Goodman, Geoffrey I. McFadden, James G. Beeson
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1455–1467. doi: 10.1128/AAC.01881-12
PMCID:
PMC3591904
Article PDF–5.9M

Mechanisms of Resistance

The Genetic Environment of the cfr Gene and the Presence of Other Mechanisms Account for the Very High Linezolid Resistance of Staphylococcus epidermidis Isolate 426-3147L
Jacqueline LaMarre, Rodrigo E. Mendes, Teresa Szal, Stefan Schwarz, Ronald N. Jones, Alexander S. Mankin
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1173–1179. doi: 10.1128/AAC.02047-12
PMCID:
PMC3591885
Article PDF–583K
Quantitative Contributions of Target Alteration and Decreased Drug Accumulation to Pseudomonas aeruginosa Fluoroquinolone Resistance
Sebastian Bruchmann, Andreas Dötsch, Bianka Nouri, Iris F. Chaberny, Susanne Häussler
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1361–1368. doi: 10.1128/AAC.01581-12
PMCID:
PMC3591863
Article PDF–706K
Mutational and Transcriptomic Changes Involved in the Development of Macrolide Resistance in Campylobacter jejuni
Haihong Hao, Zonghui Yuan, Zhangqi Shen, Jing Han, Orhan Sahin, Peng Liu, Qijing Zhang
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1369–1378. doi: 10.1128/AAC.01927-12
PMCID:
PMC3591901
Article PDF–1.2M
Reduced Vancomycin Susceptibility in an In Vitro Catheter-Related Biofilm Model Correlates with Poor Therapeutic Outcomes in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus
Wessam Abdelhady, Arnold S. Bayer, Kati Seidl, Cynthia C. Nast, Megan R. Kiedrowski, Alexander R. Horswill, Michael R. Yeaman, Yan Q. Xiong
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1447–1454. doi: 10.1128/AAC.02073-12
PMCID:
PMC3591927
Article PDF–1.2M
Arrested Protein Synthesis Increases Persister-Like Cell Formation
Brian W. Kwan, John A. Valenta, Michael J. Benedik, Thomas K. Wood
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1468–1473. doi: 10.1128/AAC.02135-12
PMCID:
PMC3591907
Article PDF–412K
Accessory Gene Regulator (agr) Dysfunction in Staphylococcus aureus Bloodstream Isolates from South Korean Patients
Yong Pil Chong, Eun Sil Kim, Su-Jin Park, Ki-Ho Park, Tark Kim, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Jin-Yong Jeong, Yang Soo Kim
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1509–1512. doi: 10.1128/AAC.01260-12
PMCID:
PMC3591919
Article PDF–120K
A Staphylococcus xylosus Isolate with a New mecC Allotype
Ewan M. Harrison, Gavin K. Paterson, Matthew T. G. Holden, Fiona J. E. Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K. Fox, Theo J. G. M. Lam, Otlis C. Sampimon, Ruth N. Zadoks, Sharon J. Peacock, Julian Parkhill, Mark A. Holmes
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1524–1528. doi: 10.1128/AAC.01882-12
PMCID:
PMC3591899
Article PDF–1.0M
High Prevalence of Fluoroquinolone-Resistant Group B Streptococci among Clinical Isolates in China and Predominance of Sequence Type 19 with Serotype III
Hui Wang, Chunjiang Zhao, Wenqiang He, Feifei Zhang, Liyan Zhang, Bin Cao, Ziyong Sun, Yingchun Xu, Qing Yang, Yaning Mei, Bijie Hu, Yunzhuo Chu, Kang Liao, Yunsong Yu, Zhidong Hu, Yuxing Ni
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1538–1541. doi: 10.1128/AAC.02317-12
PMCID:
PMC3591929
Article PDF–120K
Complete Sequence of a blaKPC-2-Harboring IncFIIK1 Plasmid from a Klebsiella pneumoniae Sequence Type 258 Strain
Liang Chen, Kalyan D. Chavda, Roberto G. Melano, Michael R. Jacobs, Michael H. Levi, Robert A. Bonomo, Barry N. Kreiswirth
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1542–1545. doi: 10.1128/AAC.02332-12
PMCID:
PMC3591897
Article PDF–209K
The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes
N. Fursova, S. Pryamchuk, A. Kruglov, I. Abaev, E. Pecherskikh, N. Kartsev, E. Svetoch, I. Dyatlov
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1552–1555. doi: 10.1128/AAC.01471-12
PMCID:
PMC3591887
Article PDF–602K

Susceptibility

Antimicrobial Susceptibility and Resistance Patterns among Helicobacter pylori Strains from The Gambia, West Africa
Ousman Secka, Douglas E. Berg, Martin Antonio, Tumani Corrah, Mary Tapgun, Robert Walton, Vivat Thomas, Juan J. Galano, Javier Sancho, Richard A. Adegbola, Julian E. Thomas
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1231–1237. doi: 10.1128/AAC.00517-12
PMCID:
PMC3591906
Article PDF–287K
Cationic Antimicrobial Peptide LL-37 Is Effective against both Extra- and Intracellular Staphylococcus aureus
Jabeen Noore, Adly Noore, Bingyun Li
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1283–1290. doi: 10.1128/AAC.01650-12
PMCID:
PMC3591932
Article PDF–1.4M
Azithromycin Kills Invasive Aggregatibacter actinomycetemcomitans in Gingival Epithelial Cells
Pin-Chuang Lai, John D. Walters
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1347–1351. doi: 10.1128/AAC.02558-12
PMCID:
PMC3591903
Article PDF–394K
Activities of Drug Combinations against Mycobacterium tuberculosis Grown in Aerobic and Hypoxic Acidic Conditions
Giovanni Piccaro, Federico Giannoni, Perla Filippini, Alessandro Mustazzolu, Lanfranco Fattorini
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1428–1433. doi: 10.1128/AAC.02154-12
PMCID:
PMC3591868
Article PDF–844K
Surveillance of Macrolide-Resistant Mycoplasma pneumoniae in Beijing, China, from 2008 to 2012
Fei Zhao, Gang Liu, Jiang Wu, Bin Cao, Xiaoxia Tao, Lihua He, Fanliang Meng, Liang Zhu, Min Lv, Yudong Yin, Jianzhong Zhang
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1521–1523. doi: 10.1128/AAC.02060-12
PMCID:
PMC3591905
Article PDF–114K
Biofilm Compared to Conventional Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Cystic Fibrosis Patients
Kitty Wu, Yvonne C. W. Yau, Larissa Matukas, Valerie Waters
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1546–1548. doi: 10.1128/AAC.02215-12
PMCID:
PMC3591893
Article PDF–346K

Antiviral Agents

Pegylated Interferon Fractal Pharmacokinetics: Individualized Dosing for Hepatitis C Virus Infection
Mamta K. Jain, Jotam G. Pasipanodya, Lara Alder, William M. Lee, Tawanda Gumbo
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1115–1120. doi: 10.1128/AAC.02208-12
PMCID:
PMC3591896
Article PDF–659K
Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction
Wei-Chun Chen, Sheng-Yang Wang, Chien-Chih Chiu, Chin-Kai Tseng, Chun-Kuang Lin, Hui-Chun Wang, Jin-Ching Lee
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1180–1191. doi: 10.1128/AAC.02053-12
PMCID:
PMC3591928
Article PDF–1.8M
Pharmacokinetics, Safety, and Tolerability of GS-9851, a Nucleotide Analog Polymerase Inhibitor for Hepatitis C Virus, following Single Ascending Doses in Healthy Subjects
Jill Denning, Melanie Cornpropst, Stephen D. Flach, Michelle M. Berrey, William T. Symonds
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1201–1208. doi: 10.1128/AAC.01262-12
PMCID:
PMC3591883
Article PDF–705K
Pharmacokinetics, Pharmacodynamics, and Tolerability of GS-9851, a Nucleotide Analog Polymerase Inhibitor, following Multiple Ascending Doses in Patients with Chronic Hepatitis C Infection
Eric Lawitz, Maribel Rodriguez-Torres, Jill M. Denning, Efsevia Albanis, Melanie Cornpropst, Michelle M. Berrey, William T. Symonds
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1209–1217. doi: 10.1128/AAC.01263-12
PMCID:
PMC3591915
Article PDF–589K
Cellular Pharmacology and Potency of HIV-1 Nucleoside Analogs in Primary Human Macrophages
Christina Gavegnano, Mervi A. Detorio, Leda Bassit, Selwyn J. Hurwitz, Thomas W. North, Raymond F. Schinazi
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1262–1269. doi: 10.1128/AAC.02012-12
PMCID:
PMC3591918
Article PDF–1.3M
Combination Treatment with Hepatitis C Virus Protease and NS5A Inhibitors Is Effective against Recombinant Genotype 1a, 2a, and 3a Viruses
Judith M. Gottwein, Sanne B. Jensen, Yi-Ping Li, Lubna Ghanem, Troels K. H. Scheel, Stéphanie B. N. Serre, Lotte Mikkelsen, Jens Bukh
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1291–1303. doi: 10.1128/AAC.02164-12
PMCID:
PMC3591891
Article PDF–2.6M
Treatment with Telbivudine Positively Regulates Antiviral Immune Profiles in Chinese Patients with Chronic Hepatitis B
Liang Ma, Yan-Jun Cai, Lei Yu, Jun-Yan Feng, Juan Wang, Cong Li, Jun-Qi Niu, Yan-Fang Jiang
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1304–1311. doi: 10.1128/AAC.02181-12
PMCID:
PMC3591912
Article PDF–2.1M
Combinations of Lambda Interferon with Direct-Acting Antiviral Agents Are Highly Efficient in Suppressing Hepatitis C Virus Replication
Jacques Friborg, Steven Levine, Chaoqun Chen, Amy K. Sheaffer, Susan Chaniewski, Stacey Voss, Julie A. Lemm, Fiona McPhee
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1312–1322. doi: 10.1128/AAC.02239-12
PMCID:
PMC3591875
Article PDF–808K
Identification of Novel Inhibitors of Human Immunodeficiency Virus Type 1 Replication by In Silico Screening Targeting Cyclin T1/Tat Interaction
Takayuki Hamasaki, Mika Okamoto, Masanori Baba
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1323–1331. doi: 10.1128/AAC.01711-12
PMCID:
PMC3591921
Article PDF–2.2M
Pharmacokinetics and Pharmacodynamics of ASP2151, a Helicase-Primase Inhibitor, in a Murine Model of Herpes Simplex Virus Infection
Kiyomitsu Katsumata, Koji Chono, Kota Kato, Yoshiaki Ohtsu, Shoji Takakura, Toru Kontani, Hiroshi Suzuki
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1339–1346. doi: 10.1128/AAC.01803-12
PMCID:
PMC3591930
Article PDF–842K
Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)
Cindy Vavro, Samiul Hasan, Heather Madsen, Joseph Horton, Felix DeAnda, Louise Martin-Carpenter, Akihiko Sato, Robert Cuffe, Shuguang Chen, Mark Underwood, Garrett Nichols
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1379–1384. doi: 10.1128/AAC.01791-12
PMCID:
PMC3591886
Article PDF–902K
Protein-Free Efavirenz Concentrations in Cerebrospinal Fluid and Blood Plasma Are Equivalent: Applying the Law of Mass Action To Predict Protein-Free Drug Concentration
L. B. Avery, N. Sacktor, J. C. McArthur, C. W. Hendrix
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1409–1414. doi: 10.1128/AAC.02329-12
Correction in:
Antimicrob Agents Chemother. 2013 Aug; 57(8): 4095.
PMCID:
PMC3591913
Article PDF–282K
Placental Transfer of Maraviroc in an Ex Vivo Human Cotyledon Perfusion Model and Influence of ABC Transporter Expression
C. Vinot, L. Gavard, J. M. Tréluyer, S. Manceau, E. Courbon, J. M. Scherrmann, X. Declèves, D. Duro, G. Peytavin, L. Mandelbrot, C. Giraud
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1415–1420. doi: 10.1128/AAC.01821-12
PMCID:
PMC3591923
Article PDF–324K
Phase Diagrams Map the Properties of Antiviral Agents Directed against Hepatitis B Virus Core Assembly
Lichun Li, Srinivas Reddy Chirapu, M. G. Finn, Adam Zlotnick
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1505–1508. doi: 10.1128/AAC.01766-12
PMCID:
PMC3591873
Article PDF–538K

Epidemiology and Surveillance

Long-Term Risk for Readmission, Methicillin-Resistant Staphylococcus aureus (MRSA) Infection, and Death among MRSA-Colonized Veterans
Nestor M. Quezada Joaquin, Daniel J. Diekema, Eli N. Perencevich, George Bailey, Patricia L. Winokur, Marin L. Schweizer
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1169–1172. doi: 10.1128/AAC.01968-12
PMCID:
PMC3591925
Article PDF–235K
Rectal Swabs Are Suitable for Quantifying the Carriage Load of KPC-Producing Carbapenem-Resistant Enterobacteriaceae
A. Lerner, J. Romano, I. Chmelnitsky, S. Navon-Venezia, R. Edgar, Y. Carmeli
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1474–1479. doi: 10.1128/AAC.01275-12
PMCID:
PMC3591867
Article PDF–503K
Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients
Laurence Armand-Lefèvre, Cécile Angebault, François Barbier, Emilie Hamelet, Gilles Defrance, Etienne Ruppé, Régis Bronchard, Raphaël Lepeule, Jean-Christophe Lucet, Assiya El Mniai, Michel Wolff, Philippe Montravers, Patrick Plésiat, Antoine Andremont
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1488–1495. doi: 10.1128/AAC.01823-12
PMCID:
PMC3591916
Article PDF–442K
High Prevalence of Antibiotic Resistance and Molecular Characterization of Integrons among Shigella Isolates in Eastern China
Yun Shen, Huimin Qian, Junjun Gong, Feifei Deng, Chen Dong, Lu Zhou, Hongxiong Guo
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1549–1551. doi: 10.1128/AAC.02102-12
PMCID:
PMC3591917
Article PDF–114K

Experimental Therapeutics

Comparison of Six Generic Vancomycin Products for Treatment of Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis in Rabbits
P. Tattevin, A. Saleh-Mghir, B. Davido, I. Ghout, L. Massias, C. Garcia de la Maria, J. M. Miró, C. Perronne, F. Laurent, A. C. Crémieux
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1157–1162. doi: 10.1128/AAC.01669-12
PMCID:
PMC3591878
Article PDF–664K
Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response
Jason Baik, Kathleen A. Stringer, Gerta Mane, Gus R. Rosania
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1218–1230. doi: 10.1128/AAC.01731-12
PMCID:
PMC3591914
Article PDF–3.9M
Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa Burn Infection: Efficacy, Safety, and Mechanism of Action
Tianhong Dai, Asheesh Gupta, Ying-Ying Huang, Rui Yin, Clinton K. Murray, Mark S. Vrahas, Margaret E. Sherwood, George P. Tegos, Michael R. Hamblin
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1238–1245. doi: 10.1128/AAC.01652-12
PMCID:
PMC3591931
Article PDF–1.1M
Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
Vincent Hernandez, Thibaut Crépin, Andrés Palencia, Stephen Cusack, Tsutomu Akama, Stephen J. Baker, Wei Bu, Lisa Feng, Yvonne R. Freund, Liang Liu, Maliwan Meewan, Manisha Mohan, Weimin Mao, Fernando L. Rock, Holly Sexton, Anita Sheoran, Yanchen Zhang, Yong-Kang Zhang, Yasheen Zhou, James A. Nieman, Mahipal Reddy Anugula, El Mehdi Keramane, Kingsley Savariraj, D. Shekhar Reddy, Rashmi Sharma, Rajendra Subedi, Rajeshwar Singh, Ann O'Leary, Nerissa L. Simon, Peter L. De Marsh, Shazad Mushtaq, Marina Warner, David M. Livermore, M. R. K. Alley, Jacob J. Plattner
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1394–1403. doi: 10.1128/AAC.02058-12
PMCID:
PMC3591879
Article PDF–936K
Evaluation of the In Vitro Activity of Voriconazole As Predictive of In Vivo Outcome in a Murine Aspergillus fumigatus Infection Model
Valentina Salas, F. Javier Pastor, Enrique Calvo, Deanna A. Sutton, Annette W. Fothergill, Josep Guarro
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1404–1408. doi: 10.1128/AAC.01331-12
PMCID:
PMC3591864
Article PDF–437K
Activities of Fosfomycin, Tigecycline, Colistin, and Gentamicin against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Foreign-Body Infection Model
Stéphane Corvec, Ulrika Furustrand Tafin, Bertrand Betrisey, Olivier Borens, Andrej Trampuz
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1421–1427. doi: 10.1128/AAC.01718-12
PMCID:
PMC3591882
Article PDF–581K
Inoculum Effects of Ceftobiprole, Daptomycin, Linezolid, and Vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at Inocula of 105 and 107 CFU Injected into Opposite Thighs of Neutropenic Mice
Dong-Gun Lee, Yoichi Murakami, David R. Andes, William A. Craig
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1434–1441. doi: 10.1128/AAC.00362-12
PMCID:
PMC3591865
Article PDF–678K
Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors
Lena Heinbockel, Susana Sánchez-Gómez, Guillermo Martinez de Tejada, Sabine Dömming, Julius Brandenburg, Yani Kaconis, Mathias Hornef, Aline Dupont, Sebastian Marwitz, Torsten Goldmann, Martin Ernst, Thomas Gutsmann, Tobias Schürholz, Klaus Brandenburg
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1480–1487. doi: 10.1128/AAC.02066-12
PMCID:
PMC3591871
Article PDF–909K
Growth Inhibition of Pathogenic Bacteria by Sulfonylurea Herbicides
Jason F. Kreisberg, Nicholas T. Ong, Aishwarya Krishna, Thomas L. Joseph, Jing Wang, Catherine Ong, Hui Ann Ooi, Julie C. Sung, Chern Chiang Siew, Grace C. Chang, Fabrice Biot, Jon Cuccui, Brendan W. Wren, Joey Chan, Suppiah P. Sivalingam, Lian-Hui Zhang, Chandra Verma, Patrick Tan
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1513–1517. doi: 10.1128/AAC.02327-12
PMCID:
PMC3591922
Article PDF–812K
Fosfomycin Synergy In Vitro with Amoxicillin, Daptomycin, and Linezolid against Vancomycin-Resistant Enterococcus faecium from Renal Transplant Patients with Infected Urinary Stents
Jillian L. Descourouez, Margaret R. Jorgenson, Justine E. Wergin, Warren E. Rose
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1518–1520. doi: 10.1128/AAC.02099-12
PMCID:
PMC3591908
Article PDF–229K
MIC Values of Voriconazole Are Predictive of Treatment Results in Murine Infections by Aspergillus terreus Species Complex
Valentina Salas, F. Javier Pastor, Deanna A. Sutton, Enrique Calvo, Emilio Mayayo, Annette W. Fothergill, Michael G. Rinaldi, Josep Guarro
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1532–1534. doi: 10.1128/AAC.01436-12
PMCID:
PMC3591889
Article PDF–544K
Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model
Selin Bardak-Ozcem, Tuncer Turhan, Oguz Resat Sipahi, Bilgin Arda, Husnu Pullukcu, Tansu Yamazhan, Meltem Isikgoz-Tasbakan, Hilal Sipahi, Sercan Ulusoy
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1556–1558. doi: 10.1128/AAC.01996-12
PMCID:
PMC3591926
Article PDF–192K

Clinical Therapeutics

Effect of Combined Fluoroquinolone and Azole Use on QT Prolongation in Hematology Patients
John D. Zeuli, John W. Wilson, Lynn L. Estes
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1121–1127. doi: 10.1128/AAC.00958-12
PMCID:
PMC3591877
Article PDF–260K
Randomized, Open-Label Trial of Primaquine against Vivax Malaria Relapse in Indonesia
Inge Sutanto, Bagus Tjahjono, Hasan Basri, W. Robert Taylor, Fauziah A. Putri, Rizka A. Meilia, Rianto Setiabudy, Siti Nurleila, Lenny L. Ekawati, Iqbal Elyazar, Jeremy Farrar, Herawati Sudoyo, J. Kevin Baird
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1128–1135. doi: 10.1128/AAC.01879-12
PMCID:
PMC3591862
Article PDF–932K
Pharmacokinetics of Intravenous Linezolid in Moderately to Morbidly Obese Adults
Amira A. Bhalodi, Pavlos K. Papasavas, Darren S. Tishler, David P. Nicolau, Joseph L. Kuti
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1144–1149. doi: 10.1128/AAC.01453-12
PMCID:
PMC3591894
Article PDF–454K
Treatment Duration for Uncomplicated Staphylococcus aureus Bacteremia To Prevent Relapse: Analysis of a Prospective Observational Cohort Study
Yong Pil Chong, Song Mi Moon, Kyung-Mi Bang, Hyun Jung Park, So-Youn Park, Mi-Na Kim, Ki-Ho Park, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jin-Yong Jeong, Jun Hee Woo, Yang Soo Kim
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1150–1156. doi: 10.1128/AAC.01021-12
PMCID:
PMC3591920
Article PDF–270K
A Trial of Discontinuation of Empiric Vancomycin Therapy in Patients with Suspected Methicillin-Resistant Staphylococcus aureus Health Care-Associated Pneumonia
John M. Boyce, Olivia-Fabiola Pop, Odaliz Abreu-Lanfranco, Whitney Y. Hung, Ann Fisher, Afshin Karjoo, Benjamin Thompson, Zenon Protopapas
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1163–1168. doi: 10.1128/AAC.01965-12
PMCID:
PMC3591869
Article PDF–143K
Multicenter Evaluation of the Clinical Outcomes of Daptomycin with and without Concomitant β-Lactams in Patients with Staphylococcus aureus Bacteremia and Mild to Moderate Renal Impairment
Pamela A. Moise, Maria Amodio-Groton, Mohamad Rashid, Kenneth C. Lamp, Holly L. Hoffman-Roberts, George Sakoulas, Min J. Yoon, Suzanne Schweitzer, Anjay Rastogi
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1192–1200. doi: 10.1128/AAC.02192-12
PMCID:
PMC3591880
Article PDF–607K
In Vivo Therapeutic Efficacy of Chloroquine Alone or in Combination with Primaquine against Vivax Malaria in Kolkata, West Bengal, India, and Polymorphism in pvmdr1 and pvcrt-o Genes
Swagata Ganguly, Pabitra Saha, Subhasish K. Guha, Sonali Das, Dilip K. Bera, Asit Biswas, Pratip K. Kundu, Bibhuti Saha, Krishnangshu Ray, Ardhendu K. Maji
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1246–1251. doi: 10.1128/AAC.02050-12
PMCID:
PMC3591881
Article PDF–265K
Outcomes of Appropriate Empiric Combination versus Monotherapy for Pseudomonas aeruginosa Bacteremia
Dana R. Bowers, Yi-Xin Liew, David C. Lye, Andrea L. Kwa, Li-Yang Hsu, Vincent H. Tam
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1270–1274. doi: 10.1128/AAC.02235-12
PMCID:
PMC3591924
Article PDF–264K
Nephrotoxicity and Efficacy Assessment of Polymyxin Use in 92 Transplant Patients
Marcelo M. Mostardeiro, Carlos A. P. Pereira, Alexandre R. Marra, Jose O. M. Pestana, Luis Fernando A. Camargo
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1442–1446. doi: 10.1128/AAC.01329-12
PMCID:
PMC3591895
Article PDF–215K
Single- and Multiple-Dose Study To Determine the Safety, Tolerability, and Pharmacokinetics of Ceftaroline Fosamil in Combination with Avibactam in Healthy Subjects
Todd A. Riccobene, Sheng Fang Su, Douglas Rank
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1496–1504. doi: 10.1128/AAC.02134-12
PMCID:
PMC3591900
Article PDF–572K

Pharmacology

Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans
Janet M. Leeds, Frederique Fenneteau, Nathalie H. Gosselin, Mohamad-Samer Mouksassi, Nastya Kassir, J. F. Marier, Yali Chen, Doug Grosenbach, Annie E. Frimm, Kady M. Honeychurch, Jarasvech Chinsangaram, Shanthakumar R. Tyavanagimatt, Dennis E. Hruby, Robert Jordan
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1136–1143. doi: 10.1128/AAC.00959-12
PMCID:
PMC3591874
Article PDF–602K
Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice
Masato Ohbuchi, Kouichi Yoshinari, Hayato Kaneko, Satoru Matsumoto, Akiko Inoue, Akio Kawamura, Takashi Usui, Yasushi Yamazoe
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1332–1338. doi: 10.1128/AAC.01900-12
PMCID:
PMC3591884
Article PDF–779K
Preliminary Pharmacokinetic Study of Repeated Doses of Rifampin and Rifapentine in Guinea Pigs
Noton K. Dutta, Abdullah Alsultan, Charles A. Peloquin, Petros C. Karakousis
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1535–1537. doi: 10.1128/AAC.01933-12
PMCID:
PMC3591898
Article PDF–102K

Letters to the Editor

Outbreak of Infections Caused by Shigella sonnei with Reduced Susceptibility to Azithromycin in the United States
Maria Sjölund Karlsson, Anna Bowen, Roshan Reporter, Jason P. Folster, Julian E. Grass, Rebecca L. Howie, Julia Taylor, Jean M. Whichard
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1559–1560. doi: 10.1128/AAC.02360-12
PMCID:
PMC3591876
Article PDF–92K
Complete Sequence of an IncN Plasmid, pIMP-HZ1, Carrying blaIMP-4 in a Klebsiella pneumoniae Strain Associated with Medical Travel to China
Wai-U Lo, Yuk-Yam Cheung, Eileen Lai, David Lung, Tak-Lun Que, Pak-Leung Ho
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1561–1562. doi: 10.1128/AAC.02298-12
PMCID:
PMC3591870
Article PDF–552K
Arginine Catabolic Mobile Element in Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Group ST239-MRSA-III Isolates in Singapore: Implications for PCR-Based Screening Tests
Pei Yun Hon, Kian Sing Chan, Matthew T. Holden, Simon R. Harris, Thean Yen Tan, Yan-Bing Zu, Prabha Krishnan, Lynette L. Oon, Tse Hsien Koh, Li Yang Hsu
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1563–1564. doi: 10.1128/AAC.02518-12
PMCID:
PMC3591910
Article PDF–252K

Masthead

Editorial Board
Antimicrob Agents Chemother. 2013 Mar; 57(3): A1.
PMCID:
PMC3591888
Article PDF–65K

Erratum

Ceftaroline Increases Membrane Binding and Enhances the Activity of Daptomycin against Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus in a Pharmacokinetic/Pharmacodynamic Model
Brian J. Werth, George Sakoulas, Warren E. Rose, Joseph Pogliano, Ryan Tewhey, Michael J. Rybak
Antimicrob Agents Chemother. 2013 Mar; 57(3): 1565. doi: 10.1128/AAC.00069-13
Corrects:
Antimicrob Agents Chemother. 2013 Jan; 57(1): 66–73.
PMCID:
PMC3591911
Correction PDF–63K
Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)