Volume 9(4); 2021 Aug

Original Articles

Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage

Antonio Franco‐Vadillo, Mireille Toledo‐Blass, Zeltzin Rivera‐Herrera, Gustavo Guevara‐Balcazar, Oscar Orihuela‐Rodriguez, Jose A. Morales‐Carmona, Alexandre Kormanovski‐Kovzova, Pedro Lopez‐Sanchez, Ivan Rubio‐Gayosso, Maria del Carmen Castillo‐Hernandez

Pharmacol Res Perspect. 2021 Aug; 9(4): e00784. Published online 2021 Jun 26. doi: 10.1002/prp2.784

PMCID:: PMC8236079

Article PDF–844K

Stathmin dynamics modulate the activity of eribulin in breast cancer cells

Mikihiro Yoshie, Akari Ishida, Haruka Ohashi, Nami Nakachi, Mana Azumi, Kazuhiro Tamura

Pharmacol Res Perspect. 2021 Aug; 9(4): e00786. Published online 2021 Jun 26. doi: 10.1002/prp2.786

PMCID:: PMC8236080

Article PDF–1.3M

Review

Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta‐analysis

Congcong Cao, Xin Zhou, Qun Ma

Pharmacol Res Perspect. 2021 Aug; 9(4): e00797. Published online 2021 Jun 14. doi: 10.1002/prp2.797

PMCID:: PMC8204091

Article PDF–776K

Original Articles

p‐cymene impairs SARS‐CoV‐2 and Influenza A (H1N1) viral replication: In silico predicted interaction with SARS‐CoV‐2 nucleocapsid protein and H1N1 nucleoprotein

Athanasios Panagiotopoulos, Melpomeni Tseliou, Ioannis Karakasiliotis, Danai‐Maria Kotzampasi, Vangelis Daskalakis, Nikolaos Kesesidis, George Notas, Christos Lionis, Marilena Kampa, Stergios Pirintsos, George Sourvinos, Elias Castanas

Pharmacol Res Perspect. 2021 Aug; 9(4): e00798. Published online 2021 Jun 14. doi: 10.1002/prp2.798

PMCID:: PMC8204097

Article PDF–1.6M

The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors

Richard G. W. Proudman, Jillian G. Baker

Pharmacol Res Perspect. 2021 Aug; 9(4): e00799. Published online 2021 Aug 6. doi: 10.1002/prp2.799

PMCID:: PMC8343220

Article PDF–2.2M

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non‐dialysis CKD: An observational study

Insa E. Emrich, Gunnar H. Heine, P. Christian Schulze, Kyrill S. Rogacev, Danilo Fliser, Stefan Wagenpfeil, Michael Böhm, Dieter Lütjohann, Oliver Weingärtner

Pharmacol Res Perspect. 2021 Aug; 9(4): e00801. Published online 2021 Jun 14. doi: 10.1002/prp2.801

PMCID:: PMC8204094

Article PDF–673K

Overall survival in metastatic melanoma correlates with pembrolizumab exposure and T cell exhaustion markers

Vishal Navani, Moira C. Graves, Giovana Celli Marchett, Hiren Mandaliya, Nikola A. Bowden, Andre van der Westhuizen

Pharmacol Res Perspect. 2021 Aug; 9(4): e00808. Published online 2021 Jun 15. doi: 10.1002/prp2.808

PMCID:: PMC8204864

Article PDF–910K

Declines and pronounced regional disparities in meperidine use in the United States

John M. Boyle, Kenneth L. McCall, Stephanie D. Nichols, Brian J. Piper

Pharmacol Res Perspect. 2021 Aug; 9(4): e00809. Published online 2021 Jun 14. doi: 10.1002/prp2.809

PMCID:: PMC8204095

Article PDF–867K

Carrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re‐analysis of randomized trial data

Harri Hemilä, Elizabeth Chalker

Pharmacol Res Perspect. 2021 Aug; 9(4): e00810. Published online 2021 Jun 14. doi: 10.1002/prp2.810

PMCID:: PMC8204093

Article PDF–809K

Sofosbuvir‐based therapies in genotype 2 hepatitis C virus cirrhosis: A real‐life experience with focus on ribavirin dose

Carlo Smirne, Antonio D'Avolio, Mattia Bellan, Alessandro Gualerzi, Maria G. Crobu, Mario Pirisi

Pharmacol Res Perspect. 2021 Aug; 9(4): e00811. Published online 2021 Jun 20. doi: 10.1002/prp2.811

PMCID:: PMC8214994

Article PDF–648K

Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non‐small‐cell lung cancer cells by regulating the miR‐526b‐5p/GRK5 axis

Ying Liu, Changchao Li, Huiqun Liu, Jing Wang

Pharmacol Res Perspect. 2021 Aug; 9(4): e00812. Published online 2021 Jul 5. doi: 10.1002/prp2.812

PMCID:: PMC8256366

Article PDF–2.1M

A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants

Chay Ngee Lim, Constantino Kantaridis, Isabelle Huyghe, Donal Gorman, Stephen Berasi, Gabriele E. Sonnenberg

Pharmacol Res Perspect. 2021 Aug; 9(4): e00813. Published online 2021 Aug 9. doi: 10.1002/prp2.813

PMCID:: PMC8351251

Article PDF–702K

Ocular safety of repeated intravitreal injections of Carboplatin and Digoxin: A preclinical study on the healthy rabbits

Alireza Khodabande, Fariba Ghassemi, Fahimeh Asadi Amoli, Hamid Riazi‐Esfahani, Raziyeh Mahmoudzadeh, Mohammad Mehrpour, Niloufar Valipour

Pharmacol Res Perspect. 2021 Aug; 9(4): e00814. Published online 2021 Jul 12. doi: 10.1002/prp2.814

PMCID:: PMC8273607

Article PDF–1.1M

Long noncoding RNA highly upregulated in liver cancer promotes the progression of hepatocellular carcinoma and attenuates the chemosensitivity of oxaliplatin by regulating miR‐383‐5p/vesicle‐associated membrane protein‐2 axis

Peng Li, Yuwei Li, Lieting Ma

Pharmacol Res Perspect. 2021 Aug; 9(4): e00815. Published online 2021 Jul 5. doi: 10.1002/prp2.815

PMCID:: PMC8256430

Article PDF–2.3M

Strength of clinical evidence leading to approval of novel cancer medicines in Europe: A systematic review and data synthesis

Alberto Farina, Federico Moro, Frederick Fasslrinner, Annahita Sedghi, Miluska Bromley, Timo Siepmann

Pharmacol Res Perspect. 2021 Aug; 9(4): e00816. Published online 2021 Jul 7. doi: 10.1002/prp2.816

PMCID:: PMC8262606

Article PDF–1.4M

Review

Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature

Sylwester Drożdżal, Kacper Lechowicz, Bartosz Szostak, Jakub Rosik, Katarzyna Kotfis, Anna Machoy‐Mokrzyńska, Monika Białecka, Kazimierz Ciechanowski, Barbara Gawrońska‐Szklarz

Pharmacol Res Perspect. 2021 Aug; 9(4): e00817. Published online 2021 Jul 26. doi: 10.1002/prp2.817

PMCID:: PMC8313037

Article PDF–779K

Original Article

Evaluating aminophylline and progesterone combination treatment to modulate contractility and labor‐related proteins in pregnant human myometrial tissues

Pei F. Lai, Roger C. Young, Rachel M. Tribe, Mark R. Johnson

Pharmacol Res Perspect. 2021 Aug; 9(4): e00818. Published online 2021 Jul 5. doi: 10.1002/prp2.818

PMCID:: PMC8256431

Article PDF–2.3M

Commentary

Commentary on Health service use and costs associated with fluoroquinolone‐related tendon injuries

Michael Kennedy

Pharmacol Res Perspect. 2021 Aug; 9(4): e00821. Published online 2021 Jul 10. doi: 10.1002/prp2.821

PMCID:: PMC8272560

Article PDF–207K

Original Articles

Polypharmacy and mortality association by chronic kidney disease status: The REasons for Geographic And Racial Differences in Stroke Study

Winn Cashion, William McClellan, Suzanne Judd, Abhinav Goyal, David Kleinbaum, Michael Goodman, Valerie Prince, Paul Muntner, George Howard

Pharmacol Res Perspect. 2021 Aug; 9(4): e00823. Published online 2021 Aug 2. doi: 10.1002/prp2.823

PMCID:: PMC8328192

Article PDF–835K

The therapeutic effects of naringenin on bronchial pneumonia in children

Wenjing Yao, Xiaopeng Zhang, Feng Xu, Chunxia Cao, Tongtong Liu, Yuanyuan Xue

Pharmacol Res Perspect. 2021 Aug; 9(4): e00825. Published online 2021 Jul 26. doi: 10.1002/prp2.825

PMCID:: PMC8312741

Article PDF–646K

Novel G‐CSF conjugated anionic globular dendrimer: Preparation and biological activity assessment

Seyed Shahaboddin Mousavi Motlagh, Mohammad Seyedhamzeh, Reza Ahangari Cohan, Mehdi Shafiee Ardestani, Behrouz Vaziri, Kayhan Azadmanesh, Sahar Saberi, Vahideh Masoumi

Pharmacol Res Perspect. 2021 Aug; 9(4): e00826. Published online 2021 Jul 16. doi: 10.1002/prp2.826

PMCID:: PMC8283867

Article PDF–4.2M

Effects of sevoflurane and adenosine receptor antagonist on the sugammadex‐induced recovery from rocuronium‐induced neuromuscular blockade in rodent phrenic nerve–hemidiaphragm tissue specimens

Yong Beom Kim, Jae‐Moon Choi, Chungon Park, Hey‐Ran Choi, Junyong In, Hong‐Seuk Yang

Pharmacol Res Perspect. 2021 Aug; 9(4): e00827. Published online 2021 Aug 1. doi: 10.1002/prp2.827

PMCID:: PMC8326504

Article PDF–783K

Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs

Jorge Gomez‐Galeno, Karl Okolotowicz, Mark Johnson, Wesley L. McKeithan, Mark Mercola, John R. Cashman

Pharmacol Res Perspect. 2021 Aug; 9(4): e00828. Published online 2021 Jul 29. doi: 10.1002/prp2.828

PMCID:: PMC8322572

Article PDF–1.0M

Review Article

An overview of diagnosis and management of drug‐induced hypomagnesemia

George Liamis, Ewout J. Hoorn, Matilda Florentin, Haralampos Milionis

Pharmacol Res Perspect. 2021 Aug; 9(4): e00829. Published online 2021 Jul 18. doi: 10.1002/prp2.829

PMCID:: PMC8287009

Article PDF–931K

Original Articles

Effects of fadolmidine, an α₂‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs

Tiina Leino, Timo Viitamaa, Jarmo S. Salonen, Ullamari Pesonen, Antti Haapalinna

Pharmacol Res Perspect. 2021 Aug; 9(4): e00830. Published online 2021 Jul 24. doi: 10.1002/prp2.830

PMCID:: PMC8308519

Article PDF–1.5M

Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters

Siennah R. Miller, Joseph L. Jilek, Meghan E. McGrath, Raymond K. Hau, Erin Q. Jennings, James J. Galligan, Stephen H. Wright, Nathan J. Cherrington

Pharmacol Res Perspect. 2021 Aug; 9(4): e00831. Published online 2021 Jul 21. doi: 10.1002/prp2.831

PMCID:: PMC8292784

Article PDF–961K

Pharmacology Education and Innovation Series

Original Article

Developing a new undergraduate pharmacology core curriculum: The British Pharmacological Society Delphi Method

Melisa J. Wallace, Anna Zecharia, Clare Guilding, Steven Tucker, Ian McFadzean

Pharmacol Res Perspect. 2021 Aug; 9(4): e00832. Published online 2021 Aug 3. doi: 10.1002/prp2.832

PMCID:: PMC8334254

Article PDF–666K

Original Articles

Answering questions in a co‐created formative exam question bank improves summative exam performance, while students perceive benefits from answering, authoring, and peer discussion: A mixed methods analysis of PeerWise

Clare Guilding, Rachel Emma Pye, Stephanie Butler, Michael Atkinson, Eimear Field

Pharmacol Res Perspect. 2021 Aug; 9(4): e00833. Published online 2021 Jul 26. doi: 10.1002/prp2.833

PMCID:: PMC8311910

Article PDF–857K

Binding interactions with sevelamer and polystyrene sulfonate in vitro

Inge R.F. van Berlo‐van de Laar, Ilona Prins‐Can, Aliesa A. de Lange, Katja Taxis, Frank G.A. Jansman

Pharmacol Res Perspect. 2021 Aug; 9(4): e00834. Published online 2021 Jul 24. doi: 10.1002/prp2.834

PMCID:: PMC8305432

Article PDF–675K

Review Article

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor

Pharmacol Res Perspect. 2021 Aug; 9(4): e00835. Published online 2021 Jul 18. doi: 10.1002/prp2.835

PMCID:: PMC8287062

Article PDF–689K

Original Articles

Identifying the core concepts of pharmacology education

Paul J. White, Elizabeth A. Davis, Marina Santiago, Tom Angelo, Alison Shield, Anna‐Marie Babey, Barbara Kemp‐Harper, Gregg Maynard, Hesham S. Al‐Sallami, Ian F. Musgrave, Lynette B. Fernandes, Suong N. T. Ngo, Tina Hinton

Pharmacol Res Perspect. 2021 Aug; 9(4): e00836. Published online 2021 Jul 21. doi: 10.1002/prp2.836

PMCID:: PMC8292785

Article PDF–1.1M

Spermidine and spermine exert protective effects within the lung

Marcin Wawrzyniak, David Groeger, Remo Frei, Ruth Ferstl, Paulina Wawrzyniak, Krzysztof Krawczyk, Benoit Pugin, Weronika Barcik, Patrick Westermann, Anita Dreher, Michael Scharl, Marek Jutel, Cezmi A. Akdis, Liam O`Mahony

Pharmacol Res Perspect. 2021 Aug; 9(4): e00837. Published online 2021 Jul 21. doi: 10.1002/prp2.837

PMCID:: PMC8294051

Article PDF–1.4M

Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet‐fed rabbits

Masashi Tawa, Katsuya Nakano, Yuka Yamashita, Qiang He, Takayoshi Masuoka, Tomio Okamura, Takaharu Ishibashi

Pharmacol Res Perspect. 2021 Aug; 9(4): e00838. Published online 2021 Jul 21. doi: 10.1002/prp2.838

PMCID:: PMC8294056

Article PDF–1.0M

TROIKA‐1: A double‐blind, randomized, parallel group, study aimed to demonstrate the equivalent pharmacokinetic profile of HD201, a potential biosimilar candidate to trastuzumab, versus EU‐Herceptin^® and US‐Herceptin^® in healthy male subjects

Martin Demarchi, Pierre Coliat, Kristi Mclendon, Jocelyn Chung Shii Hii, Peggy Feyaerts, Felicia Ang, Litha Jaison, Filip Deforce, Marie Paule Derde, Michael Jinwoo Kim, Lisa Soyeon Park, Alexandre Detappe, Xavier Pivot

Pharmacol Res Perspect. 2021 Aug; 9(4): e00839. Published online 2021 Jul 26. doi: 10.1002/prp2.839

PMCID:: PMC8311913

Article PDF–735K

Impacts of anti‐inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation

Xiao‐Fang Zheng, Dan‐Dan Chen, Xiao‐Ling Zhu, Jehane Michael Le Grange, Lu‐Qian Zhou, Jin‐Nong Zhang

Pharmacol Res Perspect. 2021 Aug; 9(4): e00840. Published online 2021 Jul 29. doi: 10.1002/prp2.840

PMCID:: PMC8322673

Article PDF–1.3M

Invited Review

Drug repurposing strategies of relevance for Parkinson’s disease

Edward J. R. Fletcher, Thomas Kaminski, Gareth Williams, Susan Duty

Pharmacol Res Perspect. 2021 Aug; 9(4): e00841. Published online 2021 Jul 26. doi: 10.1002/prp2.841

PMCID:: PMC8311732

Article PDF–763K

Original Article

Switching TNFα inhibitors: Patterns and determinants

Rosanne W. Meijboom, Helga Gardarsdottir, Matthijs L. Becker, Mark C. H. de Groot, Kris L. L. Movig, Johan Kuijvenhoven, Toine C. G. Egberts, Hubert G. M. Leufkens, Thijs J. Giezen

Pharmacol Res Perspect. 2021 Aug; 9(4): e00843. Published online 2021 Jul 24. doi: 10.1002/prp2.843

PMCID:: PMC8305431

Article PDF–877K

Review

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Ashagrachew Tewabe, Tesfa Marew, Gebremariam Birhanu

Pharmacol Res Perspect. 2021 Aug; 9(4): e00849. Published online 2021 Jul 30. doi: 10.1002/prp2.849

PMCID:: PMC8324973

Article PDF–1.2M

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