Volume 10(2); 2022 Apr

Short Report

Evaluation of cardiac parameters and other safety outcomes of brolucizumab treatment in patients with neovascular age‐related macular degeneration

Nadia Zakaria, Nicolas Guerard, Andres Emanuelli, Pravin Dugel, Jen Watts, Melissa Liew, Margarita Gekkieva, Markus Hinder

Pharmacol Res Perspect. 2022 Apr; 10(2): e00897. Published online 2022 Mar 18. doi: 10.1002/prp2.897

PMCID:: PMC8931501

Article PDF–382K

Original Article

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa de Stanchina, Nagavarakishore Pillarsetty, John L. Humm

Pharmacol Res Perspect. 2022 Apr; 10(2): e00898. Published online 2022 Mar 7. doi: 10.1002/prp2.898

PMCID:: PMC8902142

Article PDF–1.0M

Review Article

Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents

Gareth J. Sanger

Pharmacol Res Perspect. 2022 Apr; 10(2): e00900. Published online 2022 Feb 21. doi: 10.1002/prp2.900

PMCID:: PMC8860775

Article PDF–630K

Original Articles

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling

Emiliana Echeverría, Sonia Ripoll, Lucas Fabián, Carina Shayo, Federico Monczor, Natalia C. Fernández

Pharmacol Res Perspect. 2022 Apr; 10(2): e00913. Published online 2022 Feb 19. doi: 10.1002/prp2.913

PMCID:: PMC8858223

Article PDF–2.0M

Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis

An‐Liang Huang, Fan Yang, Ping Cheng, Dian‐ying Liao, Li Zhou, Xing‐Li Ji, Dou‐Dou Peng, Li Zhang, Ting‐Ting Cheng, Li Ma, Xian‐Gen Xia

Pharmacol Res Perspect. 2022 Apr; 10(2): e00914. Published online 2022 Feb 16. doi: 10.1002/prp2.914

PMCID:: PMC8848632

Article PDF–2.1M

Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice

Michiru Nagao, Masataka Tajima, Erika Sugiyama, Ryosuke Shinouchi, Keita Shibata, Masayuki Yoshikawa, Takushi Yamamoto, Vilasinee Hirunpanich Sato, Koji Nobe, Hitoshi Sato

Pharmacol Res Perspect. 2022 Apr; 10(2): e00919. Published online 2022 Mar 20. doi: 10.1002/prp2.919

PMCID:: PMC8934619

Article PDF–1.0M

Short Report

Dexamethasone promotes breast cancer stem cells in obese and not lean mice

Stephanie Annett, Orla Willis Fox, Damir Vareslija, Tracy Robson

Pharmacol Res Perspect. 2022 Apr; 10(2): e00923. Published online 2022 Mar 14. doi: 10.1002/prp2.923

PMCID:: PMC8921699

Article PDF–1.5M

Invited Review

Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic review

Nima Azh, Farzaneh Barzkar, Nogol Motamed‐Gorji, Parmida Pourvali‐Talatappeh, Yousef Moradi, Roya Vesal Azad, Mitra Ranjbar, Hamid Reza Baradaran

Pharmacol Res Perspect. 2022 Apr; 10(2): e00925. Published online 2022 Feb 26. doi: 10.1002/prp2.925

PMCID:: PMC8881905

Article PDF–2.4M

Review Article

Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic

Ian Albert Clark

Pharmacol Res Perspect. 2022 Apr; 10(2): e00926. Published online 2022 Feb 16. doi: 10.1002/prp2.926

Correction in:: Pharmacol Res Perspect. 2022 Apr; 10(2): e00942.

PMCID:: PMC8850677

Article PDF–668K

Original Articles

Distinct atrial remodeling in patients with subclinical atrial fibrillation: Lessons from computed tomographic images

Sung‐Hao Huang, Chao‐Feng Liao, Zu‐Yin Chen, Tze‐Fan Chao, Shih‐Ann Chen, Hsuan‐Ming Tsao

Pharmacol Res Perspect. 2022 Apr; 10(2): e00927. Published online 2022 Feb 22. doi: 10.1002/prp2.927

PMCID:: PMC8863578

Article PDF–800K

Healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions

Laura S.M. Kuula, Janne T. Backman, Marja L. Blom

Pharmacol Res Perspect. 2022 Apr; 10(2): e00931. Published online 2022 Feb 16. doi: 10.1002/prp2.931

PMCID:: PMC8848630

Article PDF–1.5M

CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation

Satoshi Shimizu, Atsuko Shiraki

Pharmacol Res Perspect. 2022 Apr; 10(2): e00933. Published online 2022 Mar 3. doi: 10.1002/prp2.933

PMCID:: PMC8893010

Article PDF–831K

Tamsulosin and risk of priapism: A causality assessment using Austin Bradford Hill Criteria

Mulugeta Russom, Yodit Fitsum, Merhawi Debesai, Natnael Russom, Merhawi Bahta

Pharmacol Res Perspect. 2022 Apr; 10(2): e00934. Published online 2022 Feb 16. doi: 10.1002/prp2.934

PMCID:: PMC8848631

Article PDF–491K

Impact of polymorphisms of pharmacokinetics‐related genes and the inflammatory response on the metabolism of voriconazole

Naoya Aiuchi, Junichi Nakagawa, Hirotake Sakuraba, Takenori Takahata, Kosuke Kamata, Norihiro Saito, Kayo Ueno, Masahiro Ishiyama, Kazufumi Yamagata, Hiroyuki Kayaba, Takenori Niioka

Pharmacol Res Perspect. 2022 Apr; 10(2): e00935. Published online 2022 Feb 23. doi: 10.1002/prp2.935

PMCID:: PMC8866912

Article PDF–638K

The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

Richard G.W. Proudman, Juliana Akinaga, Jillian G. Baker

Pharmacol Res Perspect. 2022 Apr; 10(2): e00936. Published online 2022 Feb 27. doi: 10.1002/prp2.936

PMCID:: PMC8882856

Article PDF–1.5M

The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker

Matthew J. Lawrence, Vanessa Evans, Janet Whitley, Suresh Pillai, Phylip R. Williams, James Coulson, Manju Krishnan, Peter Slade, Kieron Power, Roger H.K. Morris, Phillip A. Evans

Pharmacol Res Perspect. 2022 Apr; 10(2): e00937. Published online 2022 Mar 26. doi: 10.1002/prp2.937

PMCID:: PMC8956932

Article PDF–938K

Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

Xiaojun Wang, Yanping Xu, Xiaohong Yu, Asim Dey, Hong Y. Zhang, Charity M. Zink, Derek Wodka, Gina Porter, William F. Matter, Leah Porras, Charles A. Reidy, Jeffrey A. Peterson, Brian E. Mattioni, Joseph V. Haas, Mark C. Kowala, John R. Wetterau

Pharmacol Res Perspect. 2022 Apr; 10(2): e00938. Published online 2022 Feb 22. doi: 10.1002/prp2.938

PMCID:: PMC8863579

Article PDF–1.1M

Short Report

Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes

Shota Okuyama, Akari Mine, Teppei Nakamura, Yusuke Ohasi, Mayuko Seto, Masako Tada

Pharmacol Res Perspect. 2022 Apr; 10(2): e00939. Published online 2022 Feb 17. doi: 10.1002/prp2.939

PMCID:: PMC8851295

Article PDF–1.8M

Original Articles

2‐Deoxy‐d‐glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation

Ikuno Uehara, Mitsuko Kajita, Atsuko Tanimura, Shigeaki Hida, Munehiko Onda, Zenya Naito, Shinsuke Taki, Nobuyuki Tanaka

Pharmacol Res Perspect. 2022 Apr; 10(2): e00940. Published online 2022 Feb 24. doi: 10.1002/prp2.940

PMCID:: PMC8873284

Article PDF–2.4M

Community pharmacists workforce readiness to deliver vaccination services: A cross‐sectional study from Jordan

Saja A. Alnahar, Georgios Gkountouras, Rula M. Darwish, Ian Bates

Pharmacol Res Perspect. 2022 Apr; 10(2): e00943. Published online 2022 Mar 3. doi: 10.1002/prp2.943

PMCID:: PMC8893009

Article PDF–693K

Review Article

Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19

Henrik Berg Rasmussen, Ragnar Thomsen, Peter Riis Hansen

Pharmacol Res Perspect. 2022 Apr; 10(2): e00945. Published online 2022 Apr 9. doi: 10.1002/prp2.945

PMCID:: PMC8994193

Article PDF–561K

Original Article

A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity

Janna K. Duong, Romina A. Nand, Aarti Patel, Oscar Della Pasqua, Annette S. Gross

Pharmacol Res Perspect. 2022 Apr; 10(2): e00946. Published online 2022 Mar 20. doi: 10.1002/prp2.946

PMCID:: PMC8934724

Article PDF–2.4M

Corrigendum

Pharmacol Res Perspect. 2022 Apr; 10(2): e00942. Published online 2022 Mar 4. doi: 10.1002/prp2.942

Corrects:: Pharmacol Res Perspect. 2022 Apr; 10(2): e00926.

PMCID:: PMC8897282

Correction PDF–119K

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