Volume 9(12); 2019

Addiction

Protocol

Efficacy of a web-based self-help tool to reduce problem gambling in Switzerland: study protocol of a two-armed randomised controlled trial

Christian Baumgartner, Elena Bilevicius, Yasser Khazaal, Sophia Achab, Susanne Schaaf, Andreas Wenger, Severin Haug, Matthew Keough, David Hodgins, Michael P Schaub

BMJ Open. 2019; 9(12): e032110. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-032110

PMCID:: PMC6924842

Article PDF–568K

Barriers and facilitators to buprenorphine use for opioid agonist treatment: protocol for a scoping review

Pamela Leece, Triti Khorasheh, Kimberly Corace, Carol Strike, Ahmed M Bayoumi, Sheena Taha, Elisabeth Marks, Beata Pach, Keith Ahamad, Erin Grennell, Melissa Holowaty, Heather Manson, Sharon E Straus

BMJ Open. 2019; 9(12): e032285. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032285

PMCID:: PMC6924699

Article PDF–271K

Anaesthesia

Protocol

Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis

Jessica Spence, Jack Young, Waleed Alhazzani, Richard Whitlock, Frédérick D'Aragon, Kevin Um, David Mazer, Chris Beaver, Eric Jacobsohn, Emilie Belley-Cote

BMJ Open. 2019; 9(12): e031895. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031895

PMCID:: PMC6924818

Article PDF–321K

Machine learning of physiological waveforms and electronic health record data to predict, diagnose and treat haemodynamic instability in surgical patients: protocol for a retrospective study

Maxime Cannesson, Ira Hofer, Joseph Rinehart, Christine Lee, Kathirvel Subramaniam, Pierre Baldi, Artur Dubrawski, Michael R Pinsky

BMJ Open. 2019; 9(12): e031988. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-031988

PMCID:: PMC7003391

Article PDF–333K

Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study

Ulrica Nilsson, Karin Liander, Olav Rooyackers, Lars I Eriksson

BMJ Open. 2019; 9(12): e032650. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032650

PMCID:: PMC6924728

Article PDF–440K

Improving chronic pain management with eHealth and mHealth: study protocol for a randomised controlled trial

Irene Jaén, Carlos Suso-Ribera, Diana Castilla, Irene Zaragoza, Azucena García-Palacios, Jose Luis Gómez Palones

BMJ Open. 2019; 9(12): e033586. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033586

PMCID:: PMC6937108

Article PDF–428K

Cardiovascular Medicine

Original Research

Association between the number of board-certified cardiologists and the risk of in-hospital mortality: a nationwide study involving the Japanese registry of all cardiac and vascular diseases

Kihei Yoneyama, Koshiro Kanaoka, Satoshi Okayama, Kunihiro Nishimura, Michikazu Nakai, Kunihiro Matsushita, Yoshihiro Miyamoto, Keisuke Kida, Yuki Ishibashi, Masaki Izumo, Makoto Watanabe, Tsunenari Soeda, Hiroyuki Okura, Tomoo Harada, Satoshi Yasuda, Toyoaki Murohara, Hisao Ogawa, Yoshihiko Saito, Yoshihiro J Akashi

BMJ Open. 2019; 9(12): e024657. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2018-024657

PMCID:: PMC6924792

Article PDF–651K

Association between hyperlipidemia and mortality after incident acute myocardial infarction or acute decompensated heart failure: a propensity score matched cohort study and a meta-analysis

Mohammed Yousufuddin, Paul Y Takahashi, Brittny Major, Eimad Ahmmad, Hossam Al-Zubi, Jessica Peters, Taylor Doyle, Kelsey Jensen, Ruaa Y Al Ward, Umesh Sharma, Ashok Seshadri, Zhen Wang, Vinaya Simha, M Hassan Murad

BMJ Open. 2019; 9(12): e028638. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2018-028638

PMCID:: PMC6924840

Article PDF–1.1M

Development of standardised programme content for phase II cardiac rehabilitation programmes in Australia using a modified Delphi process

Susie Cartledge, Emma Thomas, Kerry Hollier, R Maddison

BMJ Open. 2019; 9(12): e032279. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-032279

PMCID:: PMC7003389

Article PDF–619K

Internal deterministic record linkage using indirect identifiers for matching of same-patient hospital transfers and early readmissions after acute coronary syndrome in a nationwide hospital discharge database: a retrospective observational validation study

Afonso Rocha, Luıs Filipe Azevedo, J C Silva Cardoso, Thomas G Allison, Alberto Freitas

BMJ Open. 2019; 9(12): e033486. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-033486

PMCID:: PMC6955528

Article PDF–315K

Protocol

Stress management in obesity during a thermal spa residential programme (ObesiStress): protocol for a randomised controlled trial study

Frédéric Dutheil, Elodie Chaplais, Audrey Vilmant, Daniel Courteix, Pascale Duche, Armand Abergel, Daniela M Pfabigan, Shihui Han, Laurie Mobdillon, Guillaume T Vallet, Martial Mermillod, Gil Boudet, Philippe Obert, Omar Izem, Magalie Miolanne-Debouit, Nicolas Farigon, Bruno Pereira, Yves Boirie

BMJ Open. 2019; 9(12): e027058. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2018-027058

PMCID:: PMC7008425

Article PDF–393K

Impact of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome: protocol for a multicentre prospective study

Dandan Li, Wei Dong, Yuqi Liu, Jingjing Wang, Yang Mu, Hao Zhou, Jing Wang, Shanshan Zhou, Yundai Chen

BMJ Open. 2019; 9(12): e031972. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-031972

PMCID:: PMC6924777

Article PDF–1.1M

New warfarin anticoagulation management model after heart valve surgery: rationale and design of a prospective, multicentre, randomised trial to compare an internet-based warfarin anticoagulation management model with the traditional warfarin management model

Zhihui Zhu, Yuehuan Li, Xu Meng, Jie Han, Yan Li, Kun Liu, Jinglun Shen, Ying Qin, Haibo Zhang

BMJ Open. 2019; 9(12): e032949. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-032949

PMCID:: PMC6924837

Article PDF–385K

Murcia atrial fibrillation project II: protocol for a prospective observational study in patients with atrial fibrillation

José Miguel Rivera-Caravaca, Francisco Marín, María Asunción Esteve-Pastor, Josefa Gálvez, Gregory Y.H. Lip, Vicente Vicente, Vanessa Roldán

BMJ Open. 2019; 9(12): e033712. Published online 2019 Dec 12. doi: 10.1136/bmjopen-2019-033712

Correction in:: BMJ Open. 2022; 12(12): e033712corr1.

PMCID:: PMC6924708

Article PDF–636K

Original Research

Does sex predict quality of life after acute coronary syndromes: an Australian, state-wide, multicentre prospective cohort study

Youlin Koh, Julia Stehli, Catherine Martin, Angela Brennan, Diem T Dinh, Jeffrey Lefkovits, Sarah Zaman

BMJ Open. 2019; 9(12): e034034. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-034034

PMCID:: PMC6937071

Article PDF–310K

Protocol

Prospective multicentre open-label randomised controlled trial of 3-month versus 12-month dual antiplatelet therapy after implantation of the new generation biodegradable polymer sirolimus TARGET-eluting coronary stent: protocol of the TARGET DAPT trial

Hongbo Yang, Feng Zhang, Ji'e Yang, Ming Zheng, Ruifen Cao, Yuxiang Dai, Chenguang Li, Kang Yao, Juying Qian, Junbo Ge

BMJ Open. 2019; 9(12): e033774. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033774

PMCID:: PMC6937074

Article PDF–376K

Screening for Hypertension in the INpatient Environment(SHINE): a protocol for a prospective study of diagnostic accuracy among adult hospital patients

Laura C Armitage, Adam Mahdi, Beth K Lawson, Cristian Roman, Thomas Fanshawe, Lionel Tarassenko, Andrew J Farmer, Peter J Watkinson

BMJ Open. 2019; 9(12): e033792. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-033792

PMCID:: PMC6924759

Article PDF–678K

Feasibility study of early outpatient review and early cardiac rehabilitation after cardiac surgery: mixed-methods research design—a study protocol

Dumbor Ngaage, Natasha Mitchell, Alexandra Dean, Claire Hirst, Enoch Akowuah, Patrick Joseph Doherty, Caroline Fairhurst, Kate Flemming, Catherine Hewitt, Sebastian Hinde, Alex Mitchell, Simon Nichols, Judith Watson

BMJ Open. 2019; 9(12): e035787. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-035787

PMCID:: PMC6937080

Article PDF–517K

Communication

Original Research

Key components of shared decision making models: a systematic review

Hanna Bomhof-Roordink, Fania R Gärtner, Anne M Stiggelbout, Arwen H Pieterse

BMJ Open. 2019; 9(12): e031763. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031763

PMCID:: PMC6937101

Article PDF–1.0M

Complementary Medicine

Protocol

Acupuncture for patients with cancer-induced xerostomia: a systematic review protocol

Xixiu Ni, Yang Yu, Tian Tian, Lu Liu, Xiao Li, Fengmei Li, Yue Xu, Ling Zhao

BMJ Open. 2019; 9(12): e031892. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-031892

PMCID:: PMC6936981

Article PDF–258K

Development of a core outcome set for myocardial infarction in clinical trials of traditional Chinese medicine: a study protocol

Ruijin Qiu, Changming Zhong, Songjie Han, Tianmai He, Ya Huang, Manke Guan, Jiayuan Hu, Min Li, Yiyi Lin, Jing Chen, Hongcai Shang

BMJ Open. 2019; 9(12): e032256. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032256

PMCID:: PMC6924774

Article PDF–1.3M

Dermatology

Original Research

Randomised controlled trial to evaluate the influence of mHealth and eHealth skin cancer prevention education among young organ transplant recipients: the HIPPOlino intervention study

Silke Böttcher, Christoph Buck, Hajo Zeeb, Gudrun Laschewski, Carolin Hauer, Gunnar Wagner, Michael Max Sachse

BMJ Open. 2019; 9(12): e028842. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2018-028842

PMCID:: PMC6937057

Article PDF–624K

Diabetes and Endocrinology

Original Research

Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial

John W Gregory, Julia Townson, Sue Channon, David Cohen, Mirella Longo, Justin Davies, Nicola Harman, Kerenza Hood, Timothy Pickles, Rebecca Playle, Tabitha Randell, Michael Robling, Morro Touray, Nicola Trevelyan, Justin Warner, Lesley Lowes

BMJ Open. 2019; 9(12): e032317. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032317

PMCID:: PMC6924753

Article PDF–581K

HbA1c variability in adults with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) therapy compared to multiple daily injection (MDI) treatment

Emma S Scott, Rachel T McGrath, Andrzej S Januszewski, Daniel Calandro, Anandwardhan A Hardikar, David N O'Neal, Gregory Fulcher, Alicia J Jenkins

BMJ Open. 2019; 9(12): e033059. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033059

PMCID:: PMC6937034

Article PDF–512K

Protocol

Prospective exploration of the effect of adiposity and associated microbial factors on healing and progression of diabetic foot ulcers in Tanzania: study protocol of a longitudinal cohort study

Fredirick Mashili, Agricola Joachim, Said Aboud, Mabulla Mchembe, Faraja Chiwanga, Juliet Addo, Lindsay Kendall, Agbor Ako, Zulfiqar Abbas

BMJ Open. 2019; 9(12): e031896. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-031896

PMCID:: PMC6937068

Article PDF–396K

What predicts regression from pre-diabetes to normal glucose regulation following a primary care nurse-delivered dietary intervention? A study protocol for a prospective cohort study

Kirsten Coppell, Trish Freer, Sally Abel, Lisa Whitehead, David Tipene-Leach, Andrew R Gray, Tony Merriman, Trudy Sullivan, Jeremy Krebs, Leigh Perreault

BMJ Open. 2019; 9(12): e033358. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033358

PMCID:: PMC6924756

Article PDF–329K

Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol

Andrew Farmer, Julie Allen, Kiera Bartlett, Peter Bower, Yuan Chi, David French, Bernard Gudgin, Emily A Holmes, Robert Horne, Dyfrig A Hughes, Cassandra Kenning, Louise Locock, Jenny McSharry, Lisa Miles, Nikki Newhouse, Rustam Rea, Evgenia Riga, Lionel Tarassenko, Carmelo Velardo, Nicola Williams, Veronika Williams, Ly-Mee Yu

BMJ Open. 2019; 9(12): e033504. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033504

PMCID:: PMC6937131

Article PDF–510K

Wahid Rezaie, Flora Lusendi, Kris Doggen, Giovanni Matricali, Frank Nobels

BMJ Open. 2019; 9(12): e034491. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-034491

PMCID:: PMC7008415

Article PDF–271K

Diagnostics

Original Research

Diagnostic accuracy of transthoracic echocardiography for pulmonary hypertension: a systematic review and meta-analysis

Jin-Rong Ni, Pei-Jing Yan, Shi-Dong Liu, Yuan Hu, Ke-Hu Yang, Bing Song, Jun-Qiang Lei

BMJ Open. 2019; 9(12): e033084. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-033084

PMCID:: PMC6937087

Article PDF–848K

Association of volume of self-directed versus assigned interpretive work with diagnostic performance of radiologists: an observational study

Shiori Amemiya, Harushi Mori, Hidemasa Takao, Osamu Abe

BMJ Open. 2019; 9(12): e033390. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033390

PMCID:: PMC6936980

Article PDF–366K

Ear, Nose and Throat/Otolaryngology

Original Research

Indications and outcomes of paediatric tracheotomy: a descriptive study using a Japanese claims database

Kayoko Mizuno, Masato Takeuchi, Yo Kishimoto, Koji Kawakami, Koichi Omori

BMJ Open. 2019; 9(12): e031816. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031816

PMCID:: PMC6937105

Article PDF–256K

Protocol

Protocol for a validation study of the translated stapesplasty outcome test 25 for measurement of disease-specific quality of life in Dutch patients with otosclerosis

Esther E Blijleven, Hans G X M Thomeer, Robert Stokroos, Inge Wegner

BMJ Open. 2019; 9(12): e030219. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-030219

PMCID:: PMC6924746

Article PDF–253K

Emergency Medicine

Original Research

Diagnostic accuracy of presepsin in predicting bacteraemia in elderly patients admitted to the emergency department: prospective study in Japan

Yoshiro Imai, Kohei Taniguchi, Ryo Iida, Masahiko Nitta, Kazuhisa Uchiyma, Akira Takasu

BMJ Open. 2019; 9(12): e030421. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-030421

PMCID:: PMC6924853

Article PDF–280K

Development of a revised Jalowiec Coping Scale for use by emergency clinicians: a cross-sectional scale development study

Jaimi H Greenslade, Marianne C Wallis, Amy Johnston, Eric Carlström, Daniel Wilhelms, Ogilvie Thom, Louisa Abraham, Julia Crilly, The WES investigators

BMJ Open. 2019; 9(12): e033053. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-033053

PMCID:: PMC7003388

Article PDF–290K

Is fascia iliaca compartment block administered by paramedics for suspected hip fracture acceptable to patients? A qualitative study

Bridie Angela Evans, Alan Brown, Greg Fegan, Simon Ford, Katy Guy, Jenna Jones, Sian Jones, Leigh Keen, Ashrafunnesa Khanom, Mirella Longo, Ian Pallister, Nigel Rees, Ian T Russell, Anne C Seagrove, Alan Watkins, Helen Snooks

BMJ Open. 2019; 9(12): e033398. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2019-033398

PMCID:: PMC6937129

Article PDF–306K

Injury from electric scooters in Copenhagen: a retrospective cohort study

Stig Nikolaj Fasmer Blomberg, Oscar Carl Moeller Rosenkrantz, Freddy Lippert, Helle Collatz Christensen

BMJ Open. 2019; 9(12): e033988. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-033988

PMCID:: PMC6936991

Article PDF–399K

Age and nationality in relation to injuries at sea among officers and non-officers: a study based on contacts from ships to Telemedical Assistance Service in Denmark

Kimmo Herttua, Stine Gerdøe-Kristensen, Jan C Vork, Jesper Bo Nielsen

BMJ Open. 2019; 9(12): e034502. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-034502

PMCID:: PMC6924698

Article PDF–290K

Protocol

Contributing factors that influence medication errors in the prehospital paramedic environment: a mixed-method systematic review protocol

Dennis Walker, Clint Moloney, Brendan SueSee, Renee Sharples

BMJ Open. 2019; 9(12): e034094. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-034094

PMCID:: PMC7008412

Article PDF–324K

Epidemiology

Cohort Profile

Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic

Katerina Sheardova, Martin Vyhnalek, Zuzana Nedelska, Jan Laczo, Ross Andel, Rafal Marciniak, Jiri Cerman, Ondrej Lerch, Jakub Hort

BMJ Open. 2019; 9(12): e030379. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-030379

PMCID:: PMC6937049

Article PDF–339K

Little in Norway: a prospective longitudinal community-based cohort from pregnancy to child age 18 months

Vibeke Moe, Eivor Fredriksen, Marian Kjellevold, Lisbeth Dahl, Maria Wik Markhus, Kjell Morten Stormark, Tilmann von Soest, Kåre Sten Olafsen, Unni Tranaas Vannebo, Lars Smith

BMJ Open. 2019; 9(12): e031050. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-031050

PMCID:: PMC6955541

Article PDF–434K

Cohort profile: HealthWise Wales. A research register and population health data platform with linkage to National Health Service data sets in Wales

Lisa Hurt, Pauline Ashfield-Watt, Julia Townson, Luke Heslop, Lauren Copeland, Mark D Atkinson, Jeffrey Horton, Shantini Paranjothy

BMJ Open. 2019; 9(12): e031705. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-031705

PMCID:: PMC7003385

Article PDF–3.7M

Original Research

Association between neck circumference and cardiometabolic disease in Chinese adults: a community-based cross-sectional study

Wenning Fu, Li Zou, Xiaoxu Yin, Jiang Wu, Shengchao Zhang, Jing Mao, Shiyi Cao, Wenzhen Li, Yong Gan, Shijiao Yan, Yanhong Gong, Zuxun Lu

BMJ Open. 2019; 9(12): e026253. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2018-026253

PMCID:: PMC6924785

Article PDF–342K

Extent of the association between self-rated health and place of birth: a cross-sectional study among people at high risk of developing pre-diabetes and diabetes in Sweden

Marina Taloyan, Amina Amri, Kristin Hjörleifsdottir Steiner, Fahimeh Lamian, Claes-Goran Ostenson, Helena Salminen

BMJ Open. 2019; 9(12): e028757. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2018-028757

PMCID:: PMC6924764

Article PDF–315K

Mapping the preclinical to clinical evidence and development trajectory of the oncolytic virus talimogene laherparepvec (T-VEC): a systematic review

Manoj Lalu, Garvin J Leung, Yuan Yi Dong, Joshua Montroy, Claire Butler, Rebecca C Auer, Dean A Fergusson

BMJ Open. 2019; 9(12): e029475. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-029475

PMCID:: PMC7003485

Article PDF–321K

Prevalence and associated risk factors of hypertension among persons aged 15–49 in India: a cross-sectional study

Soumitra Ghosh, Manish Kumar

BMJ Open. 2019; 9(12): e029714. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-029714

PMCID:: PMC6937064

Article PDF–559K

Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study

Aurore Lavigne, Anna Freni Sterrantino, Silvia Liverani, Marta Blangiardo, Kees de Hoogh, John Molitor, Anna Hansell

BMJ Open. 2019; 9(12): e030140. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-030140

PMCID:: PMC6924721

Article PDF–1.2M

Association between blood circulating vitamin D and colorectal cancer risk in Asian countries: a systematic review and dose-response meta-analysis

Lin Zhang, Huachun Zou, Yang Zhao, Chunlei Hu, Adejare Atanda, Xuzhen Qin, Peng Jia, Yu Jiang, Zhihong Qi

BMJ Open. 2019; 9(12): e030513. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-030513

PMCID:: PMC7008426

Article PDF–515K

Prevalence and correlates of depressive symptoms among gay, bisexual and other men who have sex with men in the PROUD randomised clinical trial of HIV pre-exposure prophylaxis

Ada Miltz, Fiona Lampe, Sheena McCormack, David Dunn, Ellen White, Alison Rodger, Andrew Phillips, Lorraine Sherr, Ann K Sullivan, Iain Reeves, Amanda Clarke, Mitzy Gafos

BMJ Open. 2019; 9(12): e031085. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-031085

PMCID:: PMC6924847

Article PDF–313K

Concordance of chronic conditions among the household members in Shanghai: a cross-sectional study

Yingyi Qin, Yibin Guo, Yuanjun Tang, Cheng Wu, Xinji Zhang, Qian He, Jia He

BMJ Open. 2019; 9(12): e031240. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-031240

PMCID:: PMC6937075

Article PDF–334K

Residential area deprivation and risk of subsequent hospital admission in a British population: the EPIC-Norfolk cohort

Robert Luben, Shabina Hayat, Anthony Khawaja, Nicholas Wareham, Paul P Pharoah, Kay-Tee Khaw

BMJ Open. 2019; 9(12): e031251. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-031251

PMCID:: PMC6937051

Article PDF–329K

Influence of severe knee pain, meniscus surgery and knee arthroplasty on physical ability: an observational study of 114 949 adults in the CONSTANCES cohort

Remi Valter, Diane Godeau, Annette Leclerc, Alexis Descatha, Marc Fadel

BMJ Open. 2019; 9(12): e031549. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031549

PMCID:: PMC6924791

Article PDF–352K

Association between severity of depressive symptoms and chronic knee pain in Korean adults aged over 50 years: a cross-sectional study using nationally representative data

Su-Bin Han, Sook-Hyun Lee, In-Hyuk Ha, Eun-Jung Kim

BMJ Open. 2019; 9(12): e032451. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032451

PMCID:: PMC6937089

Article PDF–379K

How youth cognitive and sociodemographic factors relate to the development of overweight and obesity in the UK and the USA: a prospective cross-cohort study of the National Child Development Study and National Longitudinal Study of Youth 1979

Drew M Altschul, Christina Wraw, Catharine R Gale, Ian J Deary

BMJ Open. 2019; 9(12): e033011. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033011

PMCID:: PMC6937025

Article PDF–395K

Multimorbidity patterns in patients with heart failure: an observational Spanish study based on electronic health records

Antonio Gimeno-Miguel, Anyuli Gracia Gutiérrez, Beatriz Poblador-Plou, Carlos Coscollar-Santaliestra, J Ignacio Pérez-Calvo, Miguel J Divo, Amaia Calderón-Larrañaga, Alexandra Prados-Torres, Fernando J Ruiz-Laiglesia

BMJ Open. 2019; 9(12): e033174. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033174

PMCID:: PMC7008407

Article PDF–313K

Sociodemographic, labour market marginalisation and medical characteristics as risk factors for reinfarction and mortality within 1 year after a first acute myocardial infarction: a register-based cohort study of a working age population in Sweden

Mo Wang, Marjan Vaez, Thomas Ernst Dorner, Syed Ghulam Rahman, Magnus Helgesson, Torbjörn Ivert, Ellenor Mittendorfer-Rutz

BMJ Open. 2019; 9(12): e033616. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-033616

PMCID:: PMC6937026

Article PDF–475K

Ethics

Original Research

Enhancing fieldworkers’ performance management support in health research: an exploratory study on the views of field managers and fieldworkers from major research centres in Africa

Francis Kazungu Kombe, Vicki Marsh, Sassy Molyneux, Dorcas Mwikali Kamuya, Dorothy Ikamba, Samson Muchina Kinyanjui

BMJ Open. 2019; 9(12): e028453. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2018-028453

PMCID:: PMC6937094

Article PDF–290K

Evidence Based Practice

Original Research

Do pharmacy intervention reports adequately describe their interventions? A template for intervention description and replication analysis of reports included in a systematic review

Mícheál de Barra, Claire Scott, Marie Johnston, M De Bruin, Neil Scott, Catriona Matheson, Christine Bond, Margaret Watson

BMJ Open. 2019; 9(12): e025511. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2018-025511

PMCID:: PMC6937059

Article PDF–385K

Research priorities for the management of broken bones of the upper limb in people over 50: a UK priority setting partnership with the James Lind Alliance

Warren J Sheehan, Mark A Williams, Zoe Paskins, Matthew L Costa, Miguel Antonio Fernandez, Jenny Gould, Philip Bell, Liz Baird, Richard Grant, Patricia Ellis, Catherine White, Laura Arnel, Lauren Exell, Stephen Gwilym

BMJ Open. 2019; 9(12): e030028. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-030028

PMCID:: PMC6924751

Article PDF–487K

Protocol

Transitional care quality indicators to assess quality of care following hospitalisation for chronic obstructive pulmonary disease and heart failure: a systematic review protocol

Faith Michael, Sera Whitelaw, Harriette GC Van Spall

BMJ Open. 2019; 9(12): e032764. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032764

PMCID:: PMC6955556

Article PDF–223K

Gastroenterology and Hepatology

Original Research

Multicentre, non-interventional study of the efficacy and tolerability of linaclotide in the treatment of irritable bowel syndrome with constipation in primary, secondary and tertiary centres: the Alpine study

Daniel Pohl, Michael Fried, Dominic Lawrance, Elmar Beck, Heinz F. Hammer

BMJ Open. 2019; 9(12): e025627. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2018-025627

PMCID:: PMC6955540

Article PDF–398K

Endoscopic submucosal dissection versus endoscopic mucosal resection for patients with early gastric cancer: a meta-analysis

Maogen Tao, Xiaobo Zhou, Meiqing Hu, Jun Pan

BMJ Open. 2019; 9(12): e025803. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2018-025803

PMCID:: PMC7008428

Article PDF–349K

Acceptability to patients of screening disposable transnasal endoscopy: qualitative interview analysis

John McGoran, Andrea Bennett, Joanne Cooper, John De Caestecker, Laurence B Lovat, Neil Guha, Krish Ragunath, Sarmed S Sami

BMJ Open. 2019; 9(12): e030467. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-030467

PMCID:: PMC6924752

Article PDF–292K

Protocol

Comparative efficacy and safety of probiotics for the treatment of irritable bowel syndrome: a systematic review and network meta-analysis protocol

Man Yang, Yuanyuan Yu, Ping-Guang Lei, Jinqiu Yuan

BMJ Open. 2019; 9(12): e027376. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2018-027376

PMCID:: PMC7003387

Article PDF–204K

Establishment and assessment of the hepatic venous pressure gradient using biofluid mechanics (HVPG_BFM): protocol for a prospective, randomised, non-controlled, multicentre study

Jia-Yun Lin, Chi-Hao Zhang, Lei Zheng, Hong-Jie Li, Yi-Ming Zhu, Xiao Fan, Feng Li, Yan Xia, Ming-Zhe Huang, Sun-Hu Yang, Xiao-Liang Qi, Hai-Zhong Huo, Hui-Song Chen, Xiao-Lou Lou, Meng Luo

BMJ Open. 2019; 9(12): e028518. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-028518

PMCID:: PMC6926408

Article PDF–2.1M

General practice / Family practice

Original Research

Cross-sectional study on patient-physician aggression in Belgium: physician characteristics and aggression types

Lennart De Jager, Michel Deneyer, Ronald Buyl, Sophie Roelandt, Ralph Pacqueu, Dirk Devroey

BMJ Open. 2019; 9(12): e025942. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2018-025942

PMCID:: PMC6937035

Article PDF–462K

Incidence, diagnostic criteria and outcome following ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus in a memory clinic population: a prospective observational cross-sectional and cohort study

George Razay, Melissa Wimmer, Iain Robertson

BMJ Open. 2019; 9(12): e028103. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-028103

PMCID:: PMC6924805

Article PDF–1.3M

Admissions for ambulatory care sensitive conditions on rural islands and their association with patient experience: a multicentred prospective cohort study

Makoto Kaneko, Takuya Aoki, Masafumi Funato, Keita Yamashiro, Kaku Kuroda, Moe Kuroda, Yusuke Saishoji, Tatsuya Sakai, Syo Yonaha, Kazuhisa Motomura, Machiko Inoue

BMJ Open. 2019; 9(12): e030101. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-030101

PMCID:: PMC6936984

Article PDF–345K

Development of a prediction model to aid primary care physicians in early identification of women at high risk of developing endometriosis: cross-sectional study

Nina Julie Verket, Ragnhild Sørum Falk, Erik Qvigstad, Tom Gunnar Tanbo, Leiv Sandvik

BMJ Open. 2019; 9(12): e030346. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-030346

PMCID:: PMC6924695

Article PDF–292K

Journey to multimorbidity: longitudinal analysis exploring cardiovascular risk factors and sociodemographic determinants in an urban setting

Mark Ashworth, Stevo Durbaba, David Whitney, James Crompton, Michael Wright, Hiten Dodhia

BMJ Open. 2019; 9(12): e031649. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031649

PMCID:: PMC7008443

Article PDF–506K

Diagnostic property of direct referral from general practitioners to contrast-enhanced thoracoabdominal CT in patients with serious but non-specific symptoms or signs of cancer: a retrospective cohort study on cancer prevalence after 12 months

Marie Møller, Bue Juvik, Stine Chabert Olesen, Hanne Sandstrøm, Erling Laxafoss, Simon Bertram Reuter, Uffe Bodtger

BMJ Open. 2019; 9(12): e032019. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032019

PMCID:: PMC6955522

Article PDF–273K

Quality evaluation of community pharmacy blood pressure (BP) screening services: an English cross-sectional survey with geospatial analysis

Ravina Barrett, James Hodgkinson

BMJ Open. 2019; 9(12): e032342. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-032342

PMCID:: PMC6924779

Article PDF–318K

‘I mean what is depression?’ A qualitative exploration of UK general practitioners’ perceptions of distinctions between emotional distress and depressive disorder

Adam W A Geraghty, Miriam Santer, Charlotte Beavis, Samantha J Williams, Tony Kendrick, Berend Terluin, Paul Little, Michael Moore

BMJ Open. 2019; 9(12): e032644. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032644

PMCID:: PMC6924803

Article PDF–266K

Factors associated with antibiotic prescribing in patients with acute respiratory tract complaints in Malta: a 1-year repeated cross-sectional surveillance study

Erika A Saliba-Gustafsson, Alexandra Dunberger Hampton, Peter Zarb, Nicola Orsini, Michael A Borg, Cecilia Stålsby Lundborg

BMJ Open. 2019; 9(12): e032704. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032704

PMCID:: PMC6937012

Article PDF–325K

Determining the minimal important differences in the International Prostate Symptom Score and Overactive Bladder Questionnaire: results from an observational cohort study in Dutch primary care

Marco H Blanker, Harma Johanna Alma, Tahira Sakina Devji, Marjan Roelofs, Martijn G Steffens, Henk van der Worp

BMJ Open. 2019; 9(12): e032795. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032795

PMCID:: PMC7008409

Article PDF–333K

Association between prescription of hypnotics/anxiolytics and mortality in multimorbid and non-multimorbid patients: a longitudinal cohort study in primary care

Kristjan Linnet, Johann Agust Sigurdsson, Margret Olafia Tomasdottir, Emil Larus Sigurdsson, Larus Steinthor Gudmundsson

BMJ Open. 2019; 9(12): e033545. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-033545

PMCID:: PMC6924757

Article PDF–1007K

Protocol

Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation: rationale and design of the FRAIL-AF randomised controlled trial

Linda P T Joosten, Sander van Doorn, Arno W Hoes, Melchior C Nierman, Nynke M Wiersma, Huiberdina L Koek, Martin E W Hemels, Menno V Huisman, Kit C Roes, Rutger M van den Bor, Wim F Buding, Frans H Rutten, Geert-Jan Geersing

BMJ Open. 2019; 9(12): e032488. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032488

PMCID:: PMC6937027

Article PDF–388K

Study protocol of the BLANKET trial: a cluster randomised controlled trial on the (cost-) effectiveness of a primary care intervention for fear of cancer recurrence in cancer survivors

Yvonne L Luigjes-Huizer, Marije L van der Lee, Niek J de Wit, Charles W Helsper

BMJ Open. 2019; 9(12): e032616. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-032616

PMCID:: PMC7003381

Article PDF–279K

Geriatric Medicine

Original Research

Development of consumer information leaflets for deprescribing in older hospital inpatients: a mixed-methods study

Natali Jokanovic, Parisa Aslani, Sophie Carter, Mai Duong, Danijela Gnjidic, Jesse Jansen, David Le Couteur, Sarah Hilmer

BMJ Open. 2019; 9(12): e033303. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-033303

PMCID:: PMC6924866

Article PDF–527K

Effect of involving certified healthcare assistants in primary care in Germany: a cross-sectional study

Jonas D Senft, Michel Wensing, Regina Poss-Doering, Joachim Szecsenyi, Gunter Laux

BMJ Open. 2019; 9(12): e033325. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033325

PMCID:: PMC6936982

Article PDF–250K

Real-time utilisation of administrative data in the ED to identify older patients at risk: development and validation of the Dynamic Silver Code

Daniela Balzi, Giulia Carreras, Francesco Tonarelli, Luca Degli Esposti, Paola Michelozzi, Andrea Ungar, Luciano Gabbani, Enrico Benvenuti, Giancarlo Landini, Roberto Bernabei, Niccolò Marchionni, Mauro Di Bari

BMJ Open. 2019; 9(12): e033374. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-033374

PMCID:: PMC6937117

Article PDF–304K

Hideharu Hagiya, Toshihiro Koyama, Yoshito Zamami, Yasuhisa Tatebe, Tomoko Funahashi, Kazuaki Shinomiya, Yoshihisa Kitamura, Shiro Hinotsu, Toshiaki Sendo, Hiromi Rakugi, Mitsunobu R Kano

BMJ Open. 2019; 9(12): e033462. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-033462

PMCID:: PMC6924807

Article PDF–352K

Relationship between visual acuity and muscle mass in the Korean older population: a cross-sectional study using Korean National Health and Nutrition Examination Survey

Ji Hyun Moon, Yun Hwan Oh, Mi Hee Kong, Hyeon Ju Kim

BMJ Open. 2019; 9(12): e033846. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-033846

PMCID:: PMC6924729

Article PDF–363K

Ana Isabel Gonzalez, GONZALEZ, Christine Schmucker, Julia Nothacker, Edith Motschall, Truc Sophia Nguyen, Maria-Sophie Brueckle, Jeanet Blom, Marjan van den Akker, Kristian Röttger, Odette Wegwarth, Tammy Hoffmann, Sharon E Straus, Ferdinand M Gerlach, Joerg J Meerpohl, Christiane Muth

BMJ Open. 2019; 9(12): e034485. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-034485

PMCID:: PMC6924802

Article PDF–692K

Protocol

Understanding transitional care programmes for older adults who experience delayed discharge: a scoping review protocol

Katherine S McGilton, Shirin Vellani, Jessica Babineau, Jennifer Bethell, Susan E Bronskill, Elaine Burr, Margaret Keatings, Janet E McElhaney, Sandra McKay, Kathryn Nichol, Abeer Omar, Martine T E Puts, Anita Singh, Laura Tamblyn Watts, Walter P Wodchis, Souraya Sidani

BMJ Open. 2019; 9(12): e032149. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032149

PMCID:: PMC6937058

Article PDF–370K

Use of oral anticoagulants in older people with atrial fibrillation in UK general practice: protocol for a cohort study using the Clinical Practice Research Datalink (CPRD) database

Anneka Mitchell, Tomas J Welsh, Margaret C Watson, Julia Snowball, Anita McGrogan

BMJ Open. 2019; 9(12): e032646. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032646

PMCID:: PMC6924720

Article PDF–548K

Non-pharmacological interventions for improving quality of life of long-term care residents with dementia: a scoping review protocol

Abimbola A Akintola, Wilco P Achterberg, Monique A A Caljouw

BMJ Open. 2019; 9(12): e032661. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032661

PMCID:: PMC7008431

Article PDF–231K

Multidimensional instruments with an integral approach to identify frailty in community-dwelling people: protocol for a systematic psychometric review

Juan José Zamora-Sánchez, Vicente Gea-Caballero, Iván Julián-Rochina, Lina Jódar-Fernández, Iris Lumillo-Gutiérrez, Meritxell Sastre-Rus, Ana-María Urpí-Fernández, Edurne Zabaleta-del-Olmo

BMJ Open. 2019; 9(12): e033160. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033160

PMCID:: PMC6924862

Article PDF–287K

Global Health

Original Research

Reporting specifications regarding epilepsy practice guidelines based on the RIGHT reporting checklist: an analysis

Zhijie Wang, Yu Zhang, Wei Guo, Xiaoyang Mio Hu, Xiao Gao, Liming Lu

BMJ Open. 2019; 9(12): e029589. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-029589

PMCID:: PMC6924717

Article PDF–917K

How well do mothers recall their own and their infants’ perinatal events? A two-district study using cross-sectional stratified random sampling in Bihar, India

Joseph James Valadez, Baburam Devkota, Caroline Jeffery, Wilbur C Hadden

BMJ Open. 2019; 9(12): e031289. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-031289

PMCID:: PMC6937048

Article PDF–270K

Protocol

Hospital climate actions and assessment tools: a scoping review protocol

Connie Cai Ru Gan, Nicola Banwell, Ramon San Pascual, Cordia Chu, Ying Wei Wang

BMJ Open. 2019; 9(12): e032561. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032561

PMCID:: PMC6937036

Article PDF–238K

Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low-income and middle-income countries (LMICs): protocol for an umbrella review

Elodie Besnier, Katie Thomson, Donata Stonkute, Talal Mohammad, Nasima Akhter, Adam Todd, Magnus Rom Jensen, Astrid Kilvik, Clare Bambra

BMJ Open. 2019; 9(12): e032981. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032981

PMCID:: PMC6937061

Article PDF–749K

Understanding incentive preferences of community health workers using discrete choice experiments: a multicountry protocol for Kenya, Uganda, Bangladesh and Haiti

Smisha Agarwal, Udochisom Anaba, Timothy Abuya, Richard Kintu, Alain Casseus, Sharif Hossain, Melvin Obadha, Charlotte E Warren

BMJ Open. 2019; 9(12): e033601. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-033601

PMCID:: PMC6924748

Article PDF–326K

HIV/AIDS

Cohort Profile

Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE)

Arturo Ciccullo, Gianmaria Baldin, Amedeo Capetti, Vanni Borghi, Gaetana Sterrantino, Alessandra Latini, Giordano Madeddu, Luigi Celani, Francesca Vignale, Barbara Rossetti, Alex Dusina, Maria Vittoria Cossu, Sibilla Restelli, William Gennari, Filippo Lagi, Andrea Giacomelli, Manuela Colafigli, Lucia Brescini, Alberto Borghetti, Cristina Mussini, Stefano Rusconi, Simona Di Giambenedetto

BMJ Open. 2019; 9(12): e029960. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-029960

PMCID:: PMC7003384

Article PDF–541K

Original Research

Demographics and health profile on precursors of non-communicable diseases in adults testing for HIV in Soweto, South Africa: a cross-sectional study

Kathryn L Hopkins, Khuthadzo Hlongwane, Kennedy Otwombe, Janan Dietrich, Mireille Cheyip, Nompumelelo Khanyile, Tanya Doherty, Glenda E Gray

BMJ Open. 2019; 9(12): e030701. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-030701

PMCID:: PMC6924733

Article PDF–416K

Uptake of routine viral load testing among people living with HIV and its implementation challenges in Yangon region of Myanmar: a mixed-methods study

Khine Khine Thinn, Pruthu Thekkur, Nang Thu Thu Kyaw, Nyein Su Aye, Tin Maung Zaw, Pyae Soan, San Hone, Htun Nyunt Oo

BMJ Open. 2019; 9(12): e032678. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032678

PMCID:: PMC6924823

Article PDF–448K

Implementation of prevention of mother-to-child transmission (PMTCT) in South Africa: outcomes from a population-based birth cohort study in Paarl, Western Cape

Jennifer Pellowski, Catherine Wedderburn, Jacob A M Stadler, Whitney Barnett, Dan Stein, Landon Myer, Heather J Zar

BMJ Open. 2019; 9(12): e033259. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033259

PMCID:: PMC6924830

Article PDF–296K

Protocol

Building research capacity through programme development and research implementation in resource-limited settings - the Ipabalele study protocol: observational cohort studies determining the effect of HIV on the natural history of cervical cancer in Botswana

Surbhi Grover, Nicola Zetola, Doreen Ramogola-Masire, Memory Bvochora-Nsingo, Allison F Schnader, Rosemarie Mick, Lesego Gabaitiri, Keikantse Matlhagela, Hao Shen, Sebathu Chiyapo, Dawn Balang, Nthabiseng Phaladze, Oathokwa Nkomazana, Harvey Friedman, John Jemmott, Bagele Chilisa, Erle S Robertson

BMJ Open. 2019; 9(12): e031103. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-031103

PMCID:: PMC6955487

Article PDF–860K

Sexually transmitted infections among high-risk populations that use treatment as prevention or pre-exposure prophylaxis: a protocol for a systematic review

Makella Coudray, Sandra Kiplagat, Franklin Saumell, Purnima Madhivanan

BMJ Open. 2019; 9(12): e032054. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-032054

PMCID:: PMC6924850

Article PDF–245K

Cluster randomised controlled trial to determine the effect of peer delivery HIV self-testing to support linkage to HIV prevention among young women in rural KwaZulu-Natal, South Africa: a study protocol

Oluwafemi Atanda Adeagbo, Nondumiso Mthiyane, Carina Herbst, Paul Mee, Melissa Neuman, Jaco Dreyer, Natsayi Chimbindi, Theresa Smit, Nonhlanhla Okesola, Cheryl Johnson, Karin Hatzold, Janet Seeley, Frances Cowan, Liz Corbett, Maryam Shahmanesh

BMJ Open. 2019; 9(12): e033435. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033435

PMCID:: PMC7008432

Article PDF–1.2M

Haematology (Incl Blood Transfusion)

Protocol

A prospective, open-label, interventional study protocol to evaluate treatment efficacy of nivolumab based on serum-soluble PD-L1 concentration for patients with metastatic and unresectable renal cell carcinoma

Yukari Bando, Nobuyuki Hinata, Takashi Omori, Masato Fujisawa

BMJ Open. 2019; 9(12): e030522. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-030522

PMCID:: PMC6924736

Article PDF–332K

Bone health in symptomatic carriers of haemophilia A: a protocol for a multicentre prospective matched-cohort study

Grace H Tang, Erin Norris, Jessica Petrucci, Paula D James, Adrienne Lee, Man-Chiu Poon, Georgina Floros, Laurence Boma-Fischer, Jerry Teitel, Rosane Nisenbaum, Michelle Sholzberg

BMJ Open. 2019; 9(12): e032891. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-032891

PMCID:: PMC7003383

Article PDF–301K

Health Economics

Original Research

Economic evaluation of clinical quality registries: a systematic review

Peter Lee, Ken Chin, Danny Liew, Dion Stub, Angela L Brennan, Jeffrey Lefkovits, Ella Zomer

BMJ Open. 2019; 9(12): e030984. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-030984

PMCID:: PMC6924778

Article PDF–334K

Cost-effectiveness analysis of pembrolizumab plus chemotherapy for previously untreated metastatic non-small cell lung cancer in the USA

Xiaohui Zeng, Xiaomin Wan, Liubao Peng, Ye Peng, Fang Ma, Qiao Liu, Chongqing Tan

BMJ Open. 2019; 9(12): e031019. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031019

PMCID:: PMC6924863

Article PDF–389K

Emerging cancer incidence, mortality, hospitalisation and associated burden among Australian cancer patients, 1982 – 2014: an incidence-based approach in terms of trends, determinants and inequality

Rashidul Alam Mahumud, Khorshed Alam, Jeff Dunn, Jeff Gow

BMJ Open. 2019; 9(12): e031874. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031874

Correction in:: BMJ Open. 2020; 10(1): e031874corr1.

PMCID:: PMC6924826

Article PDF–880K

Cost-effectiveness of telephone coaching for physically inactive ambulatory care hospital patients: economic evaluation alongside the Healthy4U randomised controlled trial

Stephen Barrett, Stephen Begg, Paul O'Halloran, Michael Kingsley

BMJ Open. 2019; 9(12): e032500. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-032500

PMCID:: PMC6924747

Article PDF–313K

Health Informatics

Original Research

Characteristics of heart failure patients incurring high medical costs via matching specific health examination results and medical claim data: a cross-sectional study

Yuya Tamaki, Kana Kazawa, Hirohito Watanabe, Tantut Susanto, Michiko Moriyama

BMJ Open. 2019; 9(12): e031422. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031422

PMCID:: PMC6924797

Article PDF–412K

Protocol

Current state of science in machine learning methods for automatic infant pain evaluation using facial expression information: study protocol of a systematic review and meta-analysis

Dan Cheng, Dianbo Liu, Lisa Liang Philpotts, Dana P Turner, Timothy T Houle, Lucy Chen, Miaomiao Zhang, Jianjun Yang, Wei Zhang, Hao Deng

BMJ Open. 2019; 9(12): e030482. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-030482

PMCID:: PMC6924806

Article PDF–364K

Patient-generated health data and electronic health record integration: protocol for a scoping review

Victoria L Tiase, William Hull, Mary M McFarland, Katherine A Sward, Guilherme Del Fiol, Catherine Staes, Charlene Weir, Mollie R Cummins

BMJ Open. 2019; 9(12): e033073. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033073

PMCID:: PMC6937018

Article PDF–274K

Health Policy

Original Research

Exposure to outdoor air pollution and its human-related health outcomes: an evidence gap map

Zhuanlan Sun, Demi Zhu

BMJ Open. 2019; 9(12): e031312. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031312

PMCID:: PMC6924861

Article PDF–613K

Prevalence and factors associated with health insurance coverage in resource-poor urban settings in Nairobi, Kenya: a cross-sectional study

Peter O Otieno, Elvis Omondi Achach Wambiya, Shukri F Mohamed, Hermann Pythagore Pierre Donfouet, Martin K Mutua

BMJ Open. 2019; 9(12): e031543. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031543

PMCID:: PMC6924758

Article PDF–355K

Health Services Research

Communication

Interaction and innovation: practical strategies for inclusive consumer-driven research in health services

Maria R Dahm, Anthony Brown, Dean Martin, Maureen Williams, Brian Osborne, Jocelyne Basseal, Mary Potter, Rae-Anne Hardie, Julie Li, Judith Thomas, Andrew Georgiou

BMJ Open. 2019; 9(12): e031555. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-031555

PMCID:: PMC6936998

Article PDF–386K

Original Research

Diffusion of knowledge and behaviours among trainee doctors in an acute medical unit and implications for quality improvement work: a mixed methods social network analysis

Paul Sullivan, Ghazal Saatchi, Izaba Younis, Mary Louise Harris

BMJ Open. 2019; 9(12): e027039. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2018-027039

PMCID:: PMC6924864

Article PDF–317K

Exploring the psychometric properties of the Rainbow Model of Integrated Care measurement tool for care providers in Australia

Julian Fares, Kon Shing Kenneth Chung, Megan Passey, Jo Longman, Pim P Valentijn

BMJ Open. 2019; 9(12): e027920. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2018-027920

PMCID:: PMC6937055

Article PDF–801K

Effects of introducing a walk-in clinic on ambulatory care sensitive hospitalisations among asylum seekers in Germany: a single-centre pre–post intervention study using medical records

Celina Lichtl, Kayvan Bozorgmehr

BMJ Open. 2019; 9(12): e027945. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2018-027945

PMCID:: PMC6924737

Article PDF–365K

Improving the quality of care with a single-entry model of referral for total joint replacement: a preimplementation/postimplementation evaluation

Zaheed Damani, Eric Bohm, Hude Quan, Thomas Noseworthy, Gail MacKean, Lynda Loucks, Deborah A Marshall

BMJ Open. 2019; 9(12): e028373. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2018-028373

PMCID:: PMC7008436

Article PDF–358K

Assessment of appropriateness of hospitalisations in Ukraine: analytical framework, method and findings

Feng Zhao, Olena Doroshenko, Valery N Lekhan, Lilia V Kriachkova, Alona Goroshko

BMJ Open. 2019; 9(12): e030081. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-030081

PMCID:: PMC6924815

Article PDF–752K

Right-Site Care Programme with a community-based family medicine clinic in Singapore: secondary data analysis of its impact on mortality and healthcare utilisation

Ian Yi Han Ang, Sheryl Hui-Xian Ng, Nabilah Rahman, Milawaty Nurjono, Tat Yean Tham, Sue-Anne Toh, Hwee Lin Wee

BMJ Open. 2019; 9(12): e030718. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-030718

PMCID:: PMC6955507

Article PDF–509K

Healthcare providers’ perception of the referral system in maternal care facilities in Aceh, Indonesia: a cross-sectional study

Farah Diba, Ichsan Ichsan, Muhsin Muhsin, Marthoenis Marthoenis, Hizir Sofyan, Mohammad Andalas, Ida Monfared, Katharina Richert, Lennart Kaplan, Lisa Rogge, Siobhan Doria, Samadi Samadi, Sebastian Vollmer

BMJ Open. 2019; 9(12): e031484. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-031484

PMCID:: PMC6924809

Article PDF–477K

Improving data sharing between acute hospitals in England: an overview of health record system distribution and retrospective observational analysis of inter-hospital transitions of care

Leigh R Warren, Jonathan Clarke, Sonal Arora, Ara Darzi

BMJ Open. 2019; 9(12): e031637. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-031637

PMCID:: PMC7008454

Article PDF–589K

Community health workers involvement in preventative care in primary healthcare: a systematic scoping review

Nila Sharma, Elizabeth Harris, Jane Lloyd, Sabuj Kanti Mistry, Mark Harris

BMJ Open. 2019; 9(12): e031666. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031666

PMCID:: PMC6937114

Article PDF–440K

Associations between work satisfaction, engagement and 7-day patient mortality: a cross-sectional survey

Kirsten Brubakk, Martin Veel Svendsen, Dag Hofoss, Tonya Moen Hansen, paul Barach, Ole Tjomsland

BMJ Open. 2019; 9(12): e031704. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031704

PMCID:: PMC6924769

Article PDF–332K

Assessing the relevance and implementation of patient-centredness from the patients’ perspective in Germany: results of a Delphi study

Stefan Zeh, Eva Christalle, Pola Hahlweg, Martin Härter, Isabelle Scholl

BMJ Open. 2019; 9(12): e031741. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031741

PMCID:: PMC7008421

Article PDF–380K

Healthcare utilisation for eating disorders among patients with depression: a cross-sectional study in Taiwan

Chiu-Lan Yan, Li-Ting Kao, Ming-kung Yeh, Wu-Chien Chien, Chin-Bin Yeh

BMJ Open. 2019; 9(12): e032108. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032108

PMCID:: PMC6937097

Article PDF–368K

Deficiencies in healthcare prior to suicide and actions to deal with them: a retrospective study of investigations after suicide in Swedish healthcare

Elin Roos af Hjelmsäter, Axel Ros, Boel Andersson Gäre, Åsa Westrin

BMJ Open. 2019; 9(12): e032290. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-032290

PMCID:: PMC6924838

Article PDF–283K

Door-to-needle time for thrombolysis: a secondary analysis of the TIPS cluster randomised controlled trial

Md Golam Hasnain, Christine L Paul, John R Attia, Annika Ryan, Erin Kerr, Catherine D'Este, Alix Hall, Abul Hasnat Milton, Isobel J Hubbard, Christopher R Levi

BMJ Open. 2019; 9(12): e032482. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032482

PMCID:: PMC6924711

Article PDF–517K

Role of patient preferences in clinical practice guidelines: a multiple methods study using guidelines from oncology as a case

Fania R Gärtner, Johanneke E Portielje, Miranda Langendam, Desiree Hairwassers, Thomas Agoritsas, Brigitte Gijsen, Gerrit-Jan Liefers, Arwen H Pieterse, Anne M Stiggelbout

BMJ Open. 2019; 9(12): e032483. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-032483

PMCID:: PMC6924854

Article PDF–354K

Supporting surgeons in patient-centred complex decision-making: a qualitative analysis of the impact of a perioperative physician clinic

Clarabelle T Pham, Catherine L Gibb, Robert A Fitridge, Jon Karnon, Elizabeth Hoon

BMJ Open. 2019; 9(12): e033277. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033277

PMCID:: PMC7008411

Article PDF–264K

Providing care to refugees through mainstream general practice in the southern health region of New Zealand: a qualitative study of primary healthcare professionals’ perspectives

Lauralie Richard, Georgia Richardson, Chrystal Jaye, Tim Stokes

BMJ Open. 2019; 9(12): e034323. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-034323

PMCID:: PMC6955505

Article PDF–346K

Attitudes of physicians towards target groups and content of the discharge summary: a cross-sectional analysis in Styria, Austria

Magdalena Hoffmann, Christine Maria Schwarz, Gudrun Pregartner, Maximilian Weinrauch, Lydia Jantscher, Lars Kamolz, Gernot Brunner, Gerald Sendlhofer

BMJ Open. 2019; 9(12): e034857. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-034857

PMCID:: PMC6937118

Article PDF–279K

Protocol

DIVERT-Collaboration Action Research and Evaluation (CARE) Trial Protocol: a multiprovincial pragmatic cluster randomised trial of cardiorespiratory management in home care

Andrew P Costa, Connie Schumacher, Aaron Jones, Darly Dash, Graham Campbell, Mats Junek, Gina Agarwal, Chaim M Bell, Veronique Boscart, Susan E Bronskill, David Feeny, Paul C Hébert, George A Heckman, John P Hirdes, Linda Lee, Robert S McKelvie, Lori Mitchell, Samir K Sinha, Joy Davis, Tammy Priddle, Joanne Rose, Roslyn Gillan, Deborah Mills, Dilys Haughton

BMJ Open. 2019; 9(12): e030301. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-030301

PMCID:: PMC6924743

Article PDF–588K

Observational non-randomised controlled evaluation of the effectiveness of cancer counselling centres: a study protocol

Solveigh Paola Lingens, Georgia Schilling, Julia Harms, Holger Schulz, Christiane Bleich

BMJ Open. 2019; 9(12): e032889. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-032889

PMCID:: PMC6924776

Article PDF–460K

The Choice and Partnership Approach to community mental health and addictions services: a realist-informed scoping review protocol

Leslie Anne Campbell, Sharon E Clark, Caitlyn Ayn, Jill Chorney, Debbie Emberly, Julie MacDonald, Adrian MacKenzie, Daniel Marsh, Kylie Peacock, Lori Wozney

BMJ Open. 2019; 9(12): e033247. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033247

PMCID:: PMC7008451

Article PDF–256K

Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol

Jacob Crawshaw, Justin Presseau, Zack van Allen, Livia Pinheiro Carvalho, Kim Jordison, Shane English, Dean A Fergusson, Francois Lauzier, Alexis F Turgeon, Aimee J Sarti, Claudio Martin, Frédérick D'Aragon, Alvin Ho-ting Li, Greg Knoll, Ian Ball, Jamie Brehaut, Karen E A Burns, Marie-Chantal Fortin, Matthew Weiss, Maureen Meade, Pierre Marsolais, Sam Shemie, Sanabelle Zaabat, Sonny Dhanani, Simon C Kitto, Michaël Chassé, on behalf of the Canadian Donation and Transplantation Research Program and the Canadian Critical Care Trials Group

BMJ Open. 2019; 9(12): e034594. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-034594

PMCID:: PMC7008441

Article PDF–288K

Protocol for the CONNECT project: a mixed methods study investigating patient preferences for communication technology use in orthopaedic rehabilitation consultations

Anthony William Gilbert, Jeremy Jones, Maria Stokes, Emmanouil Mentzakis, Carl R May

BMJ Open. 2019; 9(12): e035210. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-035210

PMCID:: PMC6924859

Article PDF–372K

Supporting survivors of sexual violence: protocol for a mixed-methods, co-research study of the role, funding and commissioning of specialist services provided by the voluntary sector in England

Gill Combes, Sarah Damery, Clare Gunby, Jenny Harlock, Louise Isham, Alice Jones, Fay Maxted, Priti Parmar, Jason Schaub, Deb Smith, Julie Taylor, Caroline Bradbury-Jones

BMJ Open. 2019; 9(12): e035739. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-035739

PMCID:: PMC6937104

Article PDF–402K

Infectious Diseases

Protocol

Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study

Silvia Jiménez-Jorge, Zaira R Palacios-Baena, Clara M Rosso-Fernández, José A Girón-Ortega, Jesús Rodriguez-Baño, Pilar Retamar

BMJ Open. 2019; 9(12): e030062. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-030062

PMCID:: PMC6937003

Article PDF–401K

Pragmatic multicentre randomised controlled trial evaluating the impact of a routine molecular point-of-care ‘test-and-treat’ strategy for influenza in adults hospitalised with acute respiratory illness (FluPOC): trial protocol

Kate Beard, Nathan Brendish, Ahalya Malachira, Samuel Mills, Cathleen Chan, Stephen Poole, Tristan Clark

BMJ Open. 2019; 9(12): e031674. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031674

PMCID:: PMC6937093

Article PDF–327K

AMEND study protocol: a case–control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults

Helen Marshall, Mark McMillan, Bing Wang, Robert Booy, Hossein Afzali, Jim Buttery, Christopher C Blyth, Peter Richmond, David Shaw, David Gordon, Belinda Barton

BMJ Open. 2019; 9(12): e032583. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032583

PMCID:: PMC6937050

Article PDF–517K

Intensive Care

Original Research

The premature closure of ROMPA clinical trial: mortality reduction in septic shock by plasma adsorption

Carola Giménez-Esparza, Cristina Portillo-Requena, Francisco Colomina-Climent, José Manuel Allegue-Gallego, María Galindo-Martínez, Cristina Mollà-Jiménez, José Luis Antón-Pascual, Enrique Mármol-Peis, Cristina Dólera-Moreno, Manuel Rodríguez-Serra, José Luis Martín-Ruíz, Pablo Juan Fernández-Arroyo, Eugenia María Blasco-Císcar, José Cánovas-Robles, Enrique González-Hernández, Fernando Sánchez-Morán, Manuel Solera-Suárez, Jesús Torres-Tortajada, Antonio Palazón-Bru, Vicente F Gil-Guillen

BMJ Open. 2019; 9(12): e030139. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-030139

Correction in:: BMJ Open. 2020; 10(3): e030139corr1.

PMCID:: PMC6924739

Article PDF–408K

Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure

Natalie Pattison, Nishkantha Arulkumaran, Geraldine O'Gara, Bronwen Connolly, Sally Humphreys, Tim Walsh, Philip Hopkins, Paul Dark

BMJ Open. 2019; 9(12): e030815. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-030815

PMCID:: PMC6937020

Article PDF–343K

Protocol

Mapping structure, process and outcomes in the removal of low-value care practices in Canadian intensive care units: protocol for a mixed-methods exploratory study

Jeanna Parsons Leigh, Jennie Petersen, Chloe de Grood, Liam Whalen-Browne, Daniel Niven, Henry Thomas Stelfox

BMJ Open. 2019; 9(12): e033333. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-033333

PMCID:: PMC6937030

Article PDF–302K

Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial

Ari Moskowitz, Tuyen Yankama, Lars W Andersen, David T Huang, Michael W Donnino, Anne V Grossestreuer

BMJ Open. 2019; 9(12): e034406. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-034406

PMCID:: PMC6937040

Article PDF–266K

Medical Education and Training

Original Research

Organic or organised: an interaction analysis to identify how interactional practices influence participation in group decision meetings for residency selection

Lokke Gennissen, Anne de la Croix, Karen Stegers-Jager, Jacqueline de Graaf, Cornelia R M G Fluit, Matthijs de Hoog

BMJ Open. 2019; 9(12): e026424. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-026424

PMCID:: PMC6924762

Article PDF–261K

How medical specialists experience the effects of a mindful leadership course on their leadership capabilities: a qualitative interview study in the Netherlands

Kiki Vreeling, Wendy Kersemaekers, Linda Cillessen, Dirk van Dierendonck, Anne Speckens

BMJ Open. 2019; 9(12): e031643. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031643

PMCID:: PMC6924730

Article PDF–308K

Professionals’ perspectives on factors affecting GP trainees’ patient mix: results from an interview and focus group study among professionals working in Dutch general practice

Sarah de Bever, Suzanne C van Rhijn, Nynke van Dijk, Anneke Kramer, Mechteld R M Visser

BMJ Open. 2019; 9(12): e032182. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032182

PMCID:: PMC6924856

Article PDF–301K

Realist evaluation of UK medical education quality assurance

Paul Crampton, Leila Mehdizadeh, Michael Page, Laura Knight, Ann Griffin

BMJ Open. 2019; 9(12): e033614. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033614

PMCID:: PMC6937024

Article PDF–458K

Does ‘online confidence’ predict application success and later academic performance in medical school? A UK-based national cohort study

Paul A Tiffin, Lewis W Paton

BMJ Open. 2019; 9(12): e034437. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-034437

PMCID:: PMC6937070

Article PDF–365K

Protocol

Study design and protocol for a comprehensive evaluation of a UK massive open online course (MOOC) on quality improvement in healthcare

Sian K Smith-Lickess, Tricia Woodhead, Anna Burhouse, Christos Vasilakis

BMJ Open. 2019; 9(12): e031973. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031973

PMCID:: PMC7008416

Article PDF–394K

Medical Management

Protocol

Rituximab versus steroids and cyclophosphamide for the treatment of primary membranous nephropathy: protocol of a pilot randomised controlled trial

Francesco Scolari, Nadia Dallera, Loreto Gesualdo, Domenico Santoro, Antonello Pani, Marisa Santostefano, Sandro Feriozzi, Laila-Yasmin Mani, Giuliano Boscutti, Piergiorgio Messa, Riccardo Magistroni, Marco Quaglia, Claudio Ponticelli, Pietro Ravani

BMJ Open. 2019; 9(12): e029232. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-029232

PMCID:: PMC6924835

Article PDF–282K

Mental Health

Cohort Profile

Cohort profile: the Australian Longitudinal Study of Adults with Autism (ALSAA)

Samuel Arnold, Kitty-Rose Foley, Ye In (Jane) Hwang, Amanda L Richdale, Mirko Uljarevic, Lauren P Lawson, Ru Ying Cai, Torbjorn Falkmer, Marita Falkmer, Nick G Lennox, Anna Urbanowicz, Julian Trollor

BMJ Open. 2019; 9(12): e030798. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-030798

PMCID:: PMC6924702

Article PDF–485K

Original Research

Patient safety in inpatient mental health settings: a systematic review

Bethan Thibaut, Lindsay Helen Dewa, Sonny Christian Ramtale, Danielle D'Lima, Sheila Adam, Hutan Ashrafian, Ara Darzi, Stephanie Archer

BMJ Open. 2019; 9(12): e030230. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-030230

PMCID:: PMC7008434

Article PDF–773K

Validation study of randomly selected cases of PTSD diagnoses identified in a Swedish regional database compared with medical records: is the validity sufficient for epidemiological research?

Anna-Clara Hollander, Klara Askegård, Claudia Iddon-Escalante, Emily A Holmes, Susanne Wicks, Christina Dalman

BMJ Open. 2019; 9(12): e031964. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031964

PMCID:: PMC7008445

Article PDF–262K

Multidimensional impact of severe mental illness on family members: systematic review

Wubalem Fekadu, Awoke Mihiretu, Tom K J Craig, Abebaw Fekadu

BMJ Open. 2019; 9(12): e032391. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-032391

PMCID:: PMC6955519

Article PDF–396K

Housing situation and healthcare for patients in a psychiatric centre in Berlin, Germany: a cross-sectional patient survey

Stefanie Schreiter, Sascha Heidrich, Jamie Zulauf, Ute Saathoff, Anne Brückner, Tomislav Majic, Wulf Rössler, Meryam Schouler-Ocak, Michael R Krausz, Felix Bermpohl, Josef Bäuml, Stefan Gutwinski

BMJ Open. 2019; 9(12): e032576. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032576

PMCID:: PMC6937056

Article PDF–471K

Perceived burden in dealing with different rare diseases: a qualitative focus group study

Natalie Uhlenbusch, Bernd Löwe, Miriam K Depping

BMJ Open. 2019; 9(12): e033353. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033353

PMCID:: PMC6937088

Article PDF–283K

Resilience and associative stigma among mental health professionals in a tertiary psychiatric hospital: a cross-sectional study in Singapore

Sherilyn Chang, Louisa Picco, Edimansyah Abdin, Qi Yuan, Siow Ann Chong, Mythily Subramaniam

BMJ Open. 2019; 9(12): e033762. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033762

PMCID:: PMC6937006

Article PDF–282K

A structured medication review tool to promote psychotropic medication optimisation for adults with intellectual disability: feasibility study

Rory Sheehan, André Strydom, Louise Marston, Nicola Morant, Federico Fiori, Paramala Santosh, Angela Hassiotis

BMJ Open. 2019; 9(12): e033827. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033827

PMCID:: PMC6924735

Article PDF–490K

Protocol

Digital phenotyping for assessment and prediction of mental health outcomes: a scoping review protocol

Pier Spinazze, Yuri Rykov, Alex Bottle, Josip Car

BMJ Open. 2019; 9(12): e032255. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-032255

PMCID:: PMC6955549

Article PDF–351K

Improving mental health and physiological stress responses in mothers following traumatic childbirth and in their infants: study protocol for the Swiss TrAumatic biRth Trial (START)

Vania Sandoz, Camille Deforges, Suzannah Stuijfzand, Manuella Epiney, Yvan Vial, Nicole Sekarski, Nadine Messerli-Bürgy, Ulrike Ehlert, Myriam Bickle-Graz, Mathilde Morisod Harari, Kate Porcheret, Daniel S Schechter, Susan Ayers, Emily A Holmes, Antje Horsch

BMJ Open. 2019; 9(12): e032469. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-032469

PMCID:: PMC6955544

Article PDF–523K

Long-term outcomes in patients with severe depression after in-hospital treatment – study protocol of the depression long-term Augsburg (DELTA) study

Inge Kirchberger, Barbara Maleckar, Christine Meisinger, Jakob Linseisen, Max Schmauss, Jessica Baumgärtner

BMJ Open. 2019; 9(12): e032507. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032507

PMCID:: PMC7008442

Article PDF–284K

Effectiveness and acceptability of cognitive–behavioural therapy based interventions for maternal peripartum depression: a systematic review, meta-analysis and thematic synthesis protocol

Danelle Pettman, Heather O'Mahen, Agneta Skoog Svanberg, Louise von Essen, Cathrine Axfors, Oscar Blomberg, Joanne Woodford

BMJ Open. 2019; 9(12): e032659. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-032659

PMCID:: PMC6937015

Article PDF–513K

Community-based rehabilitation programme for adolescents with mental health conditions in Israel: a qualitative study protocol

Hila Tuaf, Hod Orkibi

BMJ Open. 2019; 9(12): e032809. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032809

PMCID:: PMC6937008

Article PDF–286K

Study protocol: an investigation of the prevalence of autism among adults admitted to acute mental health wards: a cross-sectional pilot study

Sam Tromans, Guiqing Lily Yao, Reza Kiani, Regi Alexander, Mohammed Al-Uzri, Traolach Brugha

BMJ Open. 2019; 9(12): e033169. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033169

PMCID:: PMC7008424

Article PDF–483K

Early intervention services for non-psychotic mental health disorders: a scoping review protocol

Katie Richards, Amelia Austin, Karina Allen, Ulrike Schmidt

BMJ Open. 2019; 9(12): e033656. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-033656

PMCID:: PMC6924732

Article PDF–328K

Neurology

Original Research

Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study

Naira Goukasian, Kristy S. Hwang, Tamineh Romero, Jonathan Grotts, Triet M. Do, Jenna R. Groh, Daniel R. Bateman, Liana G. Apostolova

BMJ Open. 2019; 9(12): e031947. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-031947

PMCID:: PMC6937083

Article PDF–797K

Trends in antiepileptic drug treatment and effectiveness in clinical practice in England from 2003 to 2016: a retrospective cohort study using electronic medical records

Graham Powell, John Logan, Victor Kiri, Simon Borghs

BMJ Open. 2019; 9(12): e032551. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032551

PMCID:: PMC6936987

Article PDF–702K

Protocol

Protocol for a scoping review on information needs and information-seeking behaviour of people with dementia and their non-professional caregivers

Shu Ting Au, Aijia Soong, Bhone Myint Kyaw, Lorainne Tudor Car

BMJ Open. 2019; 9(12): e028324. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-028324

PMCID:: PMC7008419

Article PDF–300K

COveRs to impRove AesthetiC ouTcome after Surgery for Chronic subdural haemAtoma by buRr hole trepanation (CORRECT-SCAR): protocol of a Swiss single-blinded, randomised controlled trial

Martin N Stienen, Kevin Akeret, Flavio Vasella, Julia Velz, Elisabeth Jehli, Pierre Scheffler, Stefanos Voglis, Oliver Bichsel, Nicolas Roydon Smoll, Oliver Bozinov, Luca Regli, Menno R Germans

BMJ Open. 2019; 9(12): e031375. Published online 2019 Dec 6. doi: 10.1136/bmjopen-2019-031375

PMCID:: PMC6924766

Article PDF–371K

Catch-up-ESUS - follow-up in embolic stroke of undetermined source (ESUS) in a prospective, open-label, observational study: study protocol and initial baseline data

Katharina Feil, Johanna Heinrich, Clemens Küpper, Katharina Müller, Christoph Laub, Aenne S von Falkenhausen, Regina Becker, Frank A Wollenweber, Stefan Kääb, Moritz F Sinner, Lars Kellert

BMJ Open. 2019; 9(12): e031716. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-031716

PMCID:: PMC6924738

Article PDF–417K

Developing a web-based patient decision aid for gastrostomy in motor neuron disease: a study protocol

Rose Maunsell, Suzanne Bloomfield, Clare Erridge, Claire Foster, Maggi Hardcastle, Anne Hogden, Alison Kidd, Dominika Lisiecka, Christopher J McDermott, Karen Morrison, Alejandra Recio-Saucedo, Louise Rickenbach, Sean White, Peter Williams, Sally J Wheelwright

BMJ Open. 2019; 9(12): e032364. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032364

PMCID:: PMC6937039

Article PDF–361K

Induced pluripotent stem cell–based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients

Keiko Imamura, Yuishin Izumi, Haruhiko Banno, Ryuji Uozumi, Satoshi Morita, Naohiro Egawa, Takashi Ayaki, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Ryosuke Oki, Koji Fujita, Naoto Takahashi, Takafumi Ikeda, Akira Shimizu, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Ryosuke Takahashi, Haruhisa Inoue

BMJ Open. 2019; 9(12): e033131. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-033131

PMCID:: PMC7003406

Article PDF–420K

Intermittent theta burst stimulation applied during early rehabilitation after stroke: study protocol for a randomised controlled trial

Lukas Hensel, Christian Grefkes, Caroline Tscherpel, Corinna Ringmaier, Daria Kraus, Stefanie Hamacher, Lukas J Volz, Gereon R Fink

BMJ Open. 2019; 9(12): e034088. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-034088

PMCID:: PMC6955550

Article PDF–373K

Nursing

Communication

Speaking Up for Fundamental Care: the ILC Aalborg Statement

Alison Kitson, Devin Carr, Tiffany Conroy, Rebecca Feo, Mette Grønkjær, Getty Huisman-de Waal, Debra Jackson, Lianne Jeffs, Jane Merkley, Åsa Muntlin Athlin, Jennifer Parr, David A Richards, Erik Elgaard Sørensen, Yvonne Wengström

BMJ Open. 2019; 9(12): e033077. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033077

PMCID:: PMC6924742

Article PDF–290K

Original Research

How do undergraduate nursing students learn in the hospital setting? A scoping review of conceptualisations, operationalisations and learning activities

Malou Stoffels, Saskia M Peerdeman, Hester E M Daelmans, Johannes C F Ket, Rashmi A Kusurkar

BMJ Open. 2019; 9(12): e029397. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-029397

PMCID:: PMC6924761

Article PDF–432K

Internal consistency and reliability of the Swiss-French translation of the venous leg ulcer self efficacy tool (VeLUSET)

Sebastian Probst, Mathieu Turcotte, Monika Buehrer Skinner

BMJ Open. 2019; 9(12): e031529. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-031529

PMCID:: PMC6924780

Article PDF–259K

Prevalence of bullying in the nursing workplace and determinant factors: a nationwide cross-sectional Polish study survey

Lena Izabela Serafin, Bożena Czarkowska-Pączek

BMJ Open. 2019; 9(12): e033819. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-033819

PMCID:: PMC7008430

Article PDF–320K

Advanced practice nurses, registered nurses and medical practice assistants in new care models in Swiss primary care: a focused ethnography of their professional roles

Renata Josi, Monica Bianchi

BMJ Open. 2019; 9(12): e033929. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-033929

PMCID:: PMC6955521

Article PDF–332K

Protocol

Assessment of the use of Unna boot in the treatment of chronic venous leg ulcers in adults: systematic review protocol

Thalita Paranhos, Caroline S B Paiva, Fernanda C I Cardoso, Priscila P Apolinário, Flavia Figueiredo Azevedo, Maria G B Saidel, Henrique C Oliveira, Ariane P Dini, Ana R S O Kumakura, Maria H Melo Lima

BMJ Open. 2019; 9(12): e032091. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032091

PMCID:: PMC7008408

Article PDF–221K

Nutrition and Metabolism

Original Research

‘Am I really hungry?’ A qualitative exploration of patients’ experience, adherence and behaviour change during hunger training: a pilot study

Willemijn E de Bruin, Aimee L Ward, Rachael W Taylor, Michelle R Jospe

BMJ Open. 2019; 9(12): e032248. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032248

PMCID:: PMC6955552

Article PDF–442K

Association between Carbohydrate Quality Index and general and abdominal obesity in women: a cross-sectional study from Ghana

Sufyan Bakuri Suara, Fereydoun Siassi, Mahama Saaka, Abbas Rahimi Foroshani, Gity Sotoudeh

BMJ Open. 2019; 9(12): e033038. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033038

PMCID:: PMC7008417

Article PDF–294K

Obstetrics and Gynaecology

Original Research

Can a simple ‘cost-awareness’ campaign for laparoscopic hysterectomy change the use and costs of disposable surgical supplies? Pre–post non-controlled study

Sue Ross, Douglas Lier, Goldie Mackinnon, Christine Bentz, Gloria Rakowski, Valerie A Capstick

BMJ Open. 2019; 9(12): e027099. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2018-027099

PMCID:: PMC6924870

Article PDF–259K

B!RTH: a mixed-methods survey of audience members’ reflections of a global women’s health arts and science programme in England, Ireland, Scotland and Switzerland

Mary McCauley, Joanne Thomas, Cristianne Connor, Nynke van den Broek

BMJ Open. 2019; 9(12): e027531. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2018-027531

PMCID:: PMC6955564

Article PDF–382K

Experience of and access to maternity care in the UK by immigrant women: a narrative synthesis systematic review

Gina Marie Awoko Higginbottom, Catrin Evans, Myfanwy Morgan, Kuldip Kaur Bharj, Jeanette Eldridge, Basharat Hussain

BMJ Open. 2019; 9(12): e029478. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-029478

PMCID:: PMC6955508

Article PDF–755K

Pregnancy decisions after fetal or perinatal death: systematic review of qualitative research

Eleanor Dyer, Ruth Bell, Ruth Graham, Judith Rankin

BMJ Open. 2019; 9(12): e029930. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-029930

PMCID:: PMC7008435

Article PDF–526K

Qualitative exploration of women’s experiences of intramuscular pethidine or remifentanil patient-controlled analgesia for labour pain

Victoria Hall Moran, Gillian Thomson, Julie Cook, Hannah Storey, Leanne Beeson, Christine MacArthur, Matthew Wilson

BMJ Open. 2019; 9(12): e032203. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032203

PMCID:: PMC7008414

Article PDF–292K

Routine induction in late-term pregnancies: follow-up of a Danish induction of labour paradigm

Eva Rydahl, Eugene Declercq, Mette Juhl, Rikke Damkjær Maimburg

BMJ Open. 2019; 9(12): e032815. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032815

PMCID:: PMC6937045

Article PDF–613K

Analysis of caesarean section and neonatal outcome using the Robson classification in a rural district hospital in Tanzania: an observational retrospective study

Francesca Tognon, Angela Borghero, Giovanni Putoto, Donald Maziku, Giovanni Fernando Torelli, Gaetano Azzimonti, Ana Pilar Betran

BMJ Open. 2019; 9(12): e033348. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033348

PMCID:: PMC6924846

Article PDF–377K

Variation in relationships between maternal age at first birth and pregnancy outcomes by maternal race: a population-based cohort study in the United States

Laura Schummers, Michele R Hacker, Paige L Williams, Jennifer A Hutcheon, Tyler J Vanderweele, Thomas F McElrath, Sonia Hernandez-Diaz

BMJ Open. 2019; 9(12): e033697. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033697

PMCID:: PMC6924831

Article PDF–684K

Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study

Meri-Maija Ollila, Antti Kiviniemi, Elisabet Stener-Victorin, Mikko Tulppo, Katri Puukka, Juha Tapanainen, Stephen Franks, Laure Morin-Papunen, Terhi Piltonen

BMJ Open. 2019; 9(12): e033780. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033780

PMCID:: PMC6924836

Article PDF–567K

Protocol

TurnerFertility trial: PROTOCOL for an observational cohort study to describe the efficacy of ovarian tissue cryopreservation for fertility preservation in females with Turner syndrome

Myra Schleedoorn, Janielle van der Velden, Didi Braat, Ina Beerendonk, Ron van Golde, Ron Peek, Kathrin Fleischer

BMJ Open. 2019; 9(12): e030855. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-030855

PMCID:: PMC6924773

Article PDF–340K

Optimization of Fetal Biometry With 3D Ultrasound and Image Recognition (EPICEA): protocol for a prospective cross-sectional study

Gaëlle Ambroise Grandjean, Gabriela Hossu, Claire Banasiak, Cybele Ciofolo-Veit, Caroline Raynaud, Laurence Rouet, Olivier Morel, Marine Beaumont

BMJ Open. 2019; 9(12): e031777. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031777

PMCID:: PMC6924693

Article PDF–340K

Occupational and Environmental Medicine

Original Research

Evidence-based occupational health and safety interventions: a comprehensive overview of reviews

Birgit Teufer, Agnes Ebenberger, Lisa Affengruber, Christina Kien, Irma Klerings, Monika Szelag, Ludwig Grillich, Ursula Griebler

BMJ Open. 2019; 9(12): e032528. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-032528

PMCID:: PMC6924871

Article PDF–348K

Cross-sectional study of the association between long working hours and pre-diabetes: 2010-2017 Korea national health and nutrition examination survey

Yunseng Baek, Minseok Kim, Gyu Ri Kim, Eun-Cheol Park

BMJ Open. 2019; 9(12): e033579. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033579

PMCID:: PMC6937098

Article PDF–373K

Oncology

Original Research

Exploring the impact and experience of fractional work in medicine: a qualitative study of medical oncologists in Australia

Emma Kirby, Alex Broom, Deme Karikios, Rosemary Harrup, Zarnie Lwin

BMJ Open. 2019; 9(12): e032585. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-032585

PMCID:: PMC6924865

Article PDF–306K

Anticancer drug prices and clinical outcomes: a cross-sectional study in Italy

Francesco Trotta, Flavia Mayer, Francesco Barone-Adesi, Immacolata Esposito, Ranadhir Punreddy, Roberto Da Cas, Giuseppe Traversa, Francesco Perrone, Nello Martini, Bishal Gyawali, Antonio Addis

BMJ Open. 2019; 9(12): e033728. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-033728

PMCID:: PMC6924817

Article PDF–339K

Do oncology researchers adhere to reproducible and transparent principles? A cross-sectional survey of published oncology literature

Corbin Walters, Zachery J Harter, Cole Wayant, Nam Vo, Michael Warren, Justin Chronister, Daniel Tritz, Matt Vassar

BMJ Open. 2019; 9(12): e033962. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-033962

PMCID:: PMC6955516

Article PDF–328K

Protocol

Furosemide versus mannitol in Japanese patients with thoracic malignancy who received cisplatin-based chemotherapy using short hydration: study protocol for a randomised controlled trial

Eriko Murakami, Hiroaki Akamatsu, Toshio Shimokawa, Kiyoko Wada, Nobuyuki Yamamoto

BMJ Open. 2019; 9(12): e029057. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-029057

PMCID:: PMC6924869

Article PDF–364K

Components of the full blood count as risk factors for colorectal cancer detection: a systematic review protocol

Pradeep S Virdee, Shona Kirtley, Leena Elhussein, Peter J Watkinson, Tim A Holt, Jacqueline Birks

BMJ Open. 2019; 9(12): e032759. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032759

PMCID:: PMC6937079

Article PDF–282K

Simultaneous resection of the primary tumour and liver metastases after conversion chemotherapy versus standard therapy in pancreatic cancer with liver oligometastasis: protocol of a multicentre, prospective, randomised phase III control trial (CSPAC-1)

Miaoyan Wei, Si Shi, Jie Hua, Jin Xu, Xianjun Yu

BMJ Open. 2019; 9(12): e033452. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-033452

PMCID:: PMC6924808

Article PDF–423K

Breast cancer patients’ return to work (B-CARE): protocol of a longitudinal mixed-methods study aiming to explore medical and occupational rehabilitation of patients with breast cancer in Germany

Kati Hiltrop, Paula Heidkamp, Christoph Kowalski, Nicole Ernstmann

BMJ Open. 2019; 9(12): e033533. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033533

PMCID:: PMC7008453

Article PDF–284K

Family-building decision aid and planning tool for young adult women after cancer treatment: protocol for preliminary testing of a web-based decision support intervention in a single-arm pilot study

Catherine Benedict, Jennifer S Ford, Lidia Schapira, Pamela Simon, David Spiegel, Michael Diefenbach

BMJ Open. 2019; 9(12): e033630. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033630

PMCID:: PMC6937115

Article PDF–361K

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

Nadine Leonie de Boer, Alexandra R M Brandt-Kerkhof, Eva V E Madsen, Marjolein Diepeveen, Esther van Meerten, Ruben A G van Eerden, Femke M de Man, Rachida Bouamar, Stijn L W Koolen, Ignace H J T de Hingh, Checca Bakkers, Koen P Rovers, Geert-Jan M Creemers, Maarten J Deenen, Onno W Kranenburg, Alexander Constantinides, Ron H J Mathijssen, Cornelis Verhoef, Jacobus W A Burger, Dutch Peritoneal Oncology Group (DPOG), Dutch Colorectal Cancer Group (DCCG)

BMJ Open. 2019; 9(12): e034508. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-034508

PMCID:: PMC6924694

Article PDF–493K

Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol

Emma Clark, Miranda Morton, Shriya Sharma, Holly Fisher, Denise Howel, Jenn Walker, Ruth Wood, Helen Hancock, Rebecca Maier, John Marshall, Amit Bahl, Simon Crabb, Suneil Jain, Ian Pedley, Rob Jones, John Staffurth, Rakesh Heer

BMJ Open. 2019; 9(12): e034708. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-034708

PMCID:: PMC6937062

Article PDF–509K

Finding/identifying primaries with neck disease (FIND) clinical trial protocol: a study integrating transoral robotic surgery, histopathological localisation and tailored deintensification of radiotherapy for unknown primary and small oropharyngeal head and neck squamous cell carcinoma

John R de Almeida, Christopher W Noel, Maria Veigas, Rosemary Martino, Douglas B Chepeha, Scott V Bratman, David P Goldstein, Aaron R Hansen, Eugene Yu, Ur Metser, Ilan Weinreb, Bayardo Perez-Ordonez, Wei Xu, John Kim

BMJ Open. 2019; 9(12): e035431. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-035431

PMCID:: PMC6955504

Article PDF–492K

Ophthalmology

Original Research

The Only Eye Study (OnES): a qualitative study of surgeon experiences of only eye surgery and recommendations for patient safety

Lee Jones, Deanna J Taylor, Freda Sii, Imran Masood, David P Crabb, Peter Shah

BMJ Open. 2019; 9(12): e030068. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-030068

PMCID:: PMC7008410

Article PDF–280K

Protocol

Use of smartphones for detecting diabetic retinopathy: a protocol for a scoping review of diagnostic test accuracy studies

Choon Han Tan, Willie-Henri Quah, Colin S H Tan, Helen Smith, Lorainne Tudor Car

BMJ Open. 2019; 9(12): e028811. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2018-028811

PMCID:: PMC6924876

Article PDF–299K

A double masked randomised 4-week, placebo-controlled study in the USA, Thailand and Taiwan to compare the efficacy of oral valganciclovir and topical 2% ganciclovir in the treatment of cytomegalovirus anterior uveitis: study protocol

Jaskirat S Takhar, Ashlin S Joye, Thanapong Somkijrungroj, Wipada Laovirojjanakul, Chang-Ping Lin, Thomas M Lietman, Travis C Porco, Jeremy D Keenan, Elisabeth A Gebreegziabher, Gerami D Seitzman, Jennifer Rose-Nussbaumer, Thuy A Doan, Nisha R Acharya, John A Gonzales

BMJ Open. 2019; 9(12): e033175. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2019-033175

PMCID:: PMC6937053

Article PDF–324K

Paediatrics

Communication

Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view

Laura Folgori, Irja Lutsar, Joseph F Standing, A Sarah Walker, Emmanuel Roilides, Theoklis E Zaoutis, Hasan Jafri, Carlo Giaquinto, Mark A Turner, Mike Sharland

BMJ Open. 2019; 9(12): e032592. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032592

PMCID:: PMC6955510

Article PDF–271K

Original Research

Vitamin D prescribing in children in UK primary care practices: a population-based cohort study

Mandy Wan, Laura J Horsfall, Emre Basatemur, Jignesh Prakash Patel, Rukshana Shroff, Greta Rait

BMJ Open. 2019; 9(12): e031870. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-031870

PMCID:: PMC6937102

Article PDF–845K

Influence of leftover antibiotics on self-medication with antibiotics for children: a cross-sectional study from three Chinese provinces

Chenhui Sun, Yanhong Jessika Hu, Xiaomin Wang, Jingjing Lu, Leesa Lin, Xudong Zhou

BMJ Open. 2019; 9(12): e033679. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033679

PMCID:: PMC6924767

Article PDF–296K

Protocol

Multicentre, randomised trial to investigate early nasal high—flow therapy in paediatric acute hypoxaemic respiratory failure: a protocol for a randomised controlled trial—a Paediatric Acute respiratory Intervention Study (PARIS 2)

Donna Franklin, Deborah Shellshear, Franz E Babl, Luregn J Schlapbach, Ed Oakley, Meredith L Borland, Tobias Hoeppner, Shane George, Simon Craig, Jocelyn Neutze, Amanda Williams, Jason Acworth, Hamish McCay, Alex Wallace, Joerg Mattes, Vinay Gangathimn, Mark Wildman, John F Fraser, Susan Moloney, John Gavranich, John Waugh, Sue Hobbins, Rose Fahy, Simon Grew, Brenda Gannon, Kristen Gibbons, Stuart Dalziel, Andreas Schibler

BMJ Open. 2019; 9(12): e030516. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-030516

PMCID:: PMC6937038

Article PDF–491K

Training attention in children with acquired brain injury: a study protocol of a randomised controlled trial of the TALI attention training programme

Erin McKay, Sally Richmond, Hannah Kirk, Vicki Anderson, Cathy Catroppa, Kim Cornish

BMJ Open. 2019; 9(12): e032619. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-032619

PMCID:: PMC6924822

Article PDF–934K

Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal BCG vaccination in a low-mortality setting

Nicole L Messina, Kaya Gardiner, Susan Donath, Katie Flanagan, Anne-Louise Ponsonby, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Petra Zimmermann, Katie J Allen, Peter Vuillermin, Mike South, Dan Casalaz, Nigel Curtis

BMJ Open. 2019; 9(12): e032844. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032844

PMCID:: PMC6924750

Article PDF–370K

Pragmatic trial evaluating the effectiveness of a patient navigator to decrease emergency room utilisation in transition age youth with chronic conditions: the Transition Navigator Trial protocol

Susan Samuel, Gina Dimitropoulos, Kyleigh Schraeder, Scott Klarenbach, Alberto Nettel-Aguirre, Greg Guilcher, Daniele Pacaud, Jorge Pinzon, Eddy Lang, Gail Andrew, Lonnie Zwaigenbaum, Shannon Scott, Kerry McBrien, Lorraine Hamiwka, Andrew Mackie

BMJ Open. 2019; 9(12): e034309. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-034309

PMCID:: PMC6924868

Article PDF–822K

Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study

Peter J Gill, Patricia C Parkin, Nurshad Begum, Olivier Drouin, Jessica Foulds, Catherine Pound, Julie Quet, Gemma Vomiero, Gita Wahi, Mahmoud Sakran, Natascha Kozlowski, Ann Bayliss, Ronik Kanani, Anupam Sehgal, Eleanor M Pullenayegum, Arun Reginald, Nikolaus Wolter, Sanjay Mahant

BMJ Open. 2019; 9(12): e035206. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-035206

PMCID:: PMC6937073

Article PDF–304K

Palliative Care

Original Research

Social networks, social capital and end-of-life care for people with dementia: a realist review

Joseph M Sawyer, Libby Sallnow, Nuriye Kupeli, Patrick Stone, Elizabeth L Sampson

BMJ Open. 2019; 9(12): e030703. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-030703

PMCID:: PMC6924787

Article PDF–1.0M

Development of a home-visit nursing scale for helping spousal caregivers of terminal cancer patients develop positive perspectives of their caregiving experiences: a cross-sectional study

Mari Karikawa, Hisae Nakatani

BMJ Open. 2019; 9(12): e031057. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031057

PMCID:: PMC6924790

Article PDF–449K

Palliative and end of life care in prisons: a mixed-methods rapid review of the literature from 2014–2018

Chris McParland, Bridget Margaret Johnston

BMJ Open. 2019; 9(12): e033905. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033905

PMCID:: PMC7008433

Article PDF–475K

Protocol

Advance care planning for vulnerable older adults within an Accountable Care Organization: study protocol for the IMPACT randomised controlled trial

Jennifer Gabbard, NM Pajewski, Kathryn E Callahan, Ajay Dharod, Kristie Foley, Keren Ferris, Adam Moses, Carl Grey, Jeff Williamson

BMJ Open. 2019; 9(12): e032732. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032732

PMCID:: PMC6924763

Article PDF–368K

Patient-Centred Medicine

Cohort Profile

Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)

Nobuhiro Ikemura, John A Spertus, Takehiro Kimura, Kenneth Mahaffey, Jonathan P Piccini, Taku Inohara, Ikuko Ueda, Kojiro Tanimoto, Masahiro Suzuki, Iwao Nakamura, Makoto Akaishi, Hideo Mitamura, Keiichi Fukuda, Seiji Takatsuki, Shun Kohsaka

BMJ Open. 2019; 9(12): e032746. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032746

PMCID:: PMC6936990

Article PDF–364K

Original Research

Complaint risk among mental health practitioners compared with physical health practitioners: a retrospective cohort study of complaints to health regulators in Australia

Benjamin G Veness, Holly Tibble, Brin FS Grenyer, Jennifer M Morris, Matthew J Spittal, Louise Nash, David M Studdert, Marie M Bismark

BMJ Open. 2019; 9(12): e030525. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-030525

PMCID:: PMC7008450

Article PDF–472K

Identifying patient concerns during consultations in tertiary burns services: development of the Adult Burns Patient Concerns Inventory

John Alexander Gerald Gibson, Jeremy Yarrow, Liz Brown, Janine Evans, Simon N Rogers, Sally Spencer, Kayvan Shokrollahi

BMJ Open. 2019; 9(12): e032785. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-032785

PMCID:: PMC6955499

Article PDF–609K

Original Research

What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis

Martin Plöderl, Michael Pascal Hengartner

BMJ Open. 2019; 9(12): e034816. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-034816

PMCID:: PMC7008413

Article PDF–321K

Public Health

Original Research

Exploring how lifestyle weight management programmes for children are commissioned and evaluated in England: a mixed methodology study

Ruth Mears, Russ Jago, Deborah Sharp, Anamica Patel, Ruth Kipping, Julian P H Shield

BMJ Open. 2019; 9(12): e025423. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2018-025423

PMCID:: PMC6937081

Article PDF–338K

Associations between socioeconomic position and changes in children’s screen-viewing between ages 6 and 9: a longitudinal study

Ruth E Salway, Lydia Emm-Collison, Simon Sebire, Janice L Thompson, Russ Jago

BMJ Open. 2019; 9(12): e027481. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2018-027481

PMCID:: PMC6924727

Article PDF–387K

Relationship between health literacy and quality of life among cancer survivors in China: a cross-sectional study

Juan Xia, Peng Wu, Qinglong Deng, Rui Yan, Renren Yang, Binghui Lv, Jiwei Wang, Jinming Yu

BMJ Open. 2019; 9(12): e028458. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2018-028458

PMCID:: PMC6955568

Article PDF–537K

Job morale of physicians in low-income and middle-income countries: a systematic literature review of qualitative studies

Alina Sabitova, Sana Zehra Sajun, Sandra Nicholson, Franziska Mosler, Stefan Priebe

BMJ Open. 2019; 9(12): e028657. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-028657

PMCID:: PMC6924858

Article PDF–406K

Socioeconomic and behavioural determinants of overweight/obesity among adults in Botswana: a cross-sectional study

Mpho Keetile, Kannan Navaneetham, Gobopamang Letamo, Kenabetsho Bainame, Serai Daniel Rakgoasi, Lesego Gabaitiri, Tiny Masupe, Robert Molebatsi

BMJ Open. 2019; 9(12): e029570. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-029570

PMCID:: PMC6924755

Article PDF–277K

Association between caring for grandchildren and feelings of loneliness, social isolation and social network size: a cross-sectional study of community dwelling adults in Germany

Eleanor Quirke, Hans-Helmut König, André Hajek

BMJ Open. 2019; 9(12): e029605. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-029605

PMCID:: PMC7008440

Article PDF–324K

Can risk be predicted? An umbrella systematic review of current risk prediction models for cardiovascular diseases, diabetes and hypertension

Francesca Lucaroni, Domenico Cicciarella Modica, Mattia Macino, Leonardo Palombi, Alessio Abbondanzieri, Giulia Agosti, Giorgia Biondi, Laura Morciano, Antonio Vinci

BMJ Open. 2019; 9(12): e030234. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2019-030234

PMCID:: PMC6937066

Article PDF–573K

Pattern and probability of dispensing of prescription opioids and benzodiazepines among the new users in Australia: a retrospective cohort study

M Mofizul Islam

BMJ Open. 2019; 9(12): e030803. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-030803

PMCID:: PMC6955558

Article PDF–381K

Effectiveness and cost-utility of a multifaceted eHealth strategy to improve back pain beliefs of patients with non-specific low back pain: a cluster randomised trial

Arnela Suman, Frederieke G. Schaafsma, Johanna M. van Dongen, Petra J.M. Elders, Rachelle Buchbinder, Maurits W. van Tulder, Johannes R. Anema

BMJ Open. 2019; 9(12): e030879. Published online 2019 Dec 5. doi: 10.1136/bmjopen-2019-030879

PMCID:: PMC6924789

Article PDF–639K

Social relations in late adolescence and incident coronary heart disease: a 38-year follow-up of the Swedish 1969–1970 Conscription Cohort

Piroska Balog, Imre Janszky, Hua Chen, Beatrix Rafael, Tomas Hemmingsson, Krisztina D László

BMJ Open. 2019; 9(12): e030880. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-030880

PMCID:: PMC6924710

Article PDF–294K

Opportunities for improving patient experiences among medical travellers from Canada’s far north: a mixed-methods study

Kate Kerber, Fariba Kolahdooz, Meeka Otway, Melinda Laboucan, Se Lim Jang, Sue Lawrence, Suzanne Aronyk, Matthew Quinn, Stephanie Irlbacher-Fox, Crystal Milligan, Sabrina Broadhead, Debbie DeLancey, Andre Corriveau, Sangita Sharma

BMJ Open. 2019; 9(12): e030885. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-030885

PMCID:: PMC6924833

Article PDF–488K

Multicentre cross-sectional study on adverse events and good practices in maternity wards in Brazil and Mexico: same problems, different magnitude

Kelienny de Meneses Sousa, Isac Davidson Santiago Fernandes Pimenta, María Fernández Elorriaga, Pedro Jesus Saturno-Hernandez, Tatyana Maria Silva de Souza Rosendo, Marise Reis de Freitas, Wilton Rodrigues Medeiros, Quenia Camille Soares Martins, Zenewton André da Silva Gama

BMJ Open. 2019; 9(12): e030944. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-030944

PMCID:: PMC6937348

Article PDF–787K

Factors influencing active tuberculosis case-finding policy development and implementation: a scoping review

Olivia Biermann, Knut Lönnroth, Maxine Caws, Kerri Viney

BMJ Open. 2019; 9(12): e031284. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031284

PMCID:: PMC6924749

Article PDF–538K

Assessing the performance of the Asian/Pacific islander identification algorithm to infer Hmong ethnicity from electronic health records in California

May Ying N Ly, Katherine K Kim, Susan L Stewart

BMJ Open. 2019; 9(12): e031646. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031646

PMCID:: PMC6924723

Article PDF–336K

Factors associated with HIV in younger and older adult men in South Africa: findings from a cross-sectional survey

Kaymarlin Govender, Sean Edward Beckett, Gavin George, Lara Lewis, Cherie Cawood, David Khanyile, Frank Tanser, Ayesha BM Kharsany

BMJ Open. 2019; 9(12): e031667. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031667

PMCID:: PMC7008437

Article PDF–336K

Predictive accuracy of perceived baby birth size for birth weight: a cross-sectional study from the 2016 Ethiopian Demographic and Health Survey

Dabere Nigatu, Demewoz Haile, Bereket Gebremichael, Yordanos M Tiruneh

BMJ Open. 2019; 9(12): e031986. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031986

PMCID:: PMC6924872

Article PDF–395K

Time to recurrence after first-ever ischaemic stroke within 3 years and its risk factors in Chinese population: a prospective cohort study

Jing Zhang, Ping Zhu, Bingqing Liu, Qiang Yao, Ke Yan, Qianwen Zheng, Yawen Li, Lu Zhang, Mier Li, Ju Wang, Cairong Zhu, Muke Zhou

BMJ Open. 2019; 9(12): e032087. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032087

PMCID:: PMC6936994

Article PDF–374K

Preschool group practices and preschool children’s sedentary time: a cross-sectional study in Finland

Suvi Määttä, Reetta Lehto, Hanna Konttinen, Carola Ray, Nina Sajaniemi, Maijaliisa Erkkola, Eva Roos

BMJ Open. 2019; 9(12): e032210. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-032210

PMCID:: PMC6937063

Article PDF–365K

Sleep problems of healthcare workers in tertiary hospital and influencing factors identified through a multilevel analysis: a cross-sectional study in China

Huan Liu, Jingjing Liu, Mingxi Chen, Xiao Tan, Tong Zheng, Zheng Kang, Lijun Gao, Mingli Jiao, Ning Ning, Libo Liang, Qunhong Wu, Yanhua Hao

BMJ Open. 2019; 9(12): e032239. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032239

PMCID:: PMC6937086

Article PDF–359K

Drowning among fishing communities on the Tanzanian shore of lake Victoria: a mixed-methods study to examine incidence, risk factors and socioeconomic impact

Hilary S Whitworth, Joyce Pando, Christian Hansen, Natasha Howard, Amen Moshi, Otto Rocky, Happiness Mahanga, Mtoro Jabbar, Philip Ayieko, Saidi Kapiga, Heiner Grosskurth, Deborah Watson-Jones

BMJ Open. 2019; 9(12): e032428. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032428

PMCID:: PMC6924839

Article PDF–355K

Development of summary indices of antenatal care service quality in Haiti, Malawi and Tanzania

Ashley Sheffel, Scott Zeger, Rebecca Heidkamp, Melinda Kay Munos

BMJ Open. 2019; 9(12): e032558. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-032558

PMCID:: PMC7003378

Article PDF–970K

Patients’ perceptions of continuity of care across primary care level and emergency departments in Belgium: cross-sectional survey

Marlene Karam, Anne-Sophie Lambert, Jean Macq

BMJ Open. 2019; 9(12): e033188. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-033188

PMCID:: PMC6936975

Article PDF–298K

Prospective cohort study to investigate the burden and transmission of acute gastroenteritis in care homes: epidemiological results

Thomas Inns, Anna Pulawska-Czub, John P Harris, Roberto Vivancos, Nicholas J Beeching, Miren Iturriza-Gomara, Sarah J O'Brien

BMJ Open. 2019; 9(12): e033239. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-033239

PMCID:: PMC6924874

Article PDF–332K

Cost-effectiveness analysis of a physician deployment program to improve access to healthcare in rural and underserved areas in the Philippines

Anton L.V. Avanceña, Kim Patrick S Tejano, David W. Hutton

BMJ Open. 2019; 9(12): e033455. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033455

PMCID:: PMC6937106

Article PDF–553K

Healthy Dads, Healthy Kids UK, a weight management programme for fathers: feasibility RCT

Tania Griffin, Yongzhong Sun, Manbinder Sidhu, Peymane Adab, Adrienne Burgess, Clare Collins, Amanda Daley, Andrew Entwistle, Emma Frew, Pollyanna Hardy, Kiya Hurley, Laura Jones, Eleanor McGee, Miranda Pallan, Myles Young, Philip Morgan, Kate Jolly

BMJ Open. 2019; 9(12): e033534. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-033534

PMCID:: PMC6924741

Article PDF–347K

Active commute to school: does distance from school or walkability of the home neighbourhood matter? A national cross-sectional study of children aged 10–11 years, Scotland, UK

Laura Macdonald, Paul McCrorie, Natalie Nicholls, Jonathan R Olsen

BMJ Open. 2019; 9(12): e033628. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033628

PMCID:: PMC7008418

Article PDF–436K

Effect of social integration on the establishment of health records among elderly migrants in China: a nationwide cross-sectional study

Zhengyue Jing, Yi Wang, Lulu Ding, Xue Tang, Yuejing Feng, Chengchao Zhou

BMJ Open. 2019; 9(12): e034255. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-034255

PMCID:: PMC6955514

Article PDF–300K

How representative are colorectal, lung, breast and prostate cancer patients responding to the National Cancer Patient Experience Survey (CPES) of the cancer registry population in England? A population-based case control study

Saleh A Alessy, Elizabeth A Davies, Janette Rawlinson, Matthew Baker, Margreet Lüchtenborg

BMJ Open. 2019; 9(12): e034344. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-034344

PMCID:: PMC6937072

Article PDF–374K

Protocol

Lending an Ear: iPeer2Peer plus Teens Taking Charge online self-management to empower adolescents with arthritis in Ireland: protocol for a pilot randomised controlled trial

Siobhan O'Higgins, Jennifer Stinson, Sara Ahola Kohut, Line Caes, Caroline Heary, Brian E McGuire, Team Pain, Centre for Pain Research, School of Psychology, NUI Galway

BMJ Open. 2019; 9(12): e027952. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2018-027952

PMCID:: PMC7008438

Article PDF–543K

Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: the txt2heart Colombia randomised controlled trial protocol

Anderson Bermon, Ana Fernanda Uribe-Rodríguez, Paula Fernanda Pérez-Rivero, David Prieto-Merino, Diana Isabel Cáceres Rivera, Elizabeth Guio, Louise Atkins, Robert Horne, Elizabeth Murray, Norma Cecilia Serrano Díaz, Caroline Free, Pablo Perel, Juan P Casas

BMJ Open. 2019; 9(12): e028017. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2018-028017

PMCID:: PMC6924706

Article PDF–397K

Sleep duration and eating behaviours in youth: a scoping review protocol

Natalie Doan, Mark A Ferro

BMJ Open. 2019; 9(12): e030457. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-030457

PMCID:: PMC6924725

Article PDF–269K

Storytelling as a research tool and intervention around public health perceptions and behaviour: a protocol for a systematic narrative review

Becky McCall, Laura Shallcross, Michael Wilson, Christopher Fuller, Andrew Hayward

BMJ Open. 2019; 9(12): e030597. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-030597

PMCID:: PMC6924770

Article PDF–280K

Effect of a simple intervention on hand hygiene related diseases in preschools in South Africa: research protocol for an intervention study

Samantha Louise Lange, Tobias George Barnard, Nisha Naicker

BMJ Open. 2019; 9(12): e030656. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2019-030656

PMCID:: PMC6936989

Article PDF–552K

Development and evaluation of an intervention based on the provision of patient feedback to improve patient safety in Spanish primary healthcare centres: study protocol

Maria J Serrano-Ripoll, Joana Ripoll, Joan Llobera, Jose Maria Valderas, Guadalupe Pastor-Moreno, Antonio Olry de Labry Lima, Ignacio Ricci-Cabello

BMJ Open. 2019; 9(12): e031367. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-031367

PMCID:: PMC7008422

Article PDF–443K

Testing the effectiveness of a weight loss intervention to enhance self-regulation in adults who are obese: protocol for a randomised controlled trial

Kerstin Frie, Jamie Hartmann-Boyce, Susan A Jebb, Paul Aveyard

BMJ Open. 2019; 9(12): e031572. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-031572

PMCID:: PMC6924834

Article PDF–716K

Protocol for an economic evaluation alongside a cluster randomised controlled trial: cost-effectiveness of Learning Clubs, a multicomponent intervention to improve women’s health and infant’s health and development in Vietnam

Trang Nguyen, Kim Sweeny, Thach Tran, Stanley Luchters, David B Hipgrave, Sarah Hanieh, Tuan Tran, Ha Tran, Beverley-Ann Biggs, Jane Fisher

BMJ Open. 2019; 9(12): e031721. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031721

PMCID:: PMC6924726

Article PDF–383K

Evaluation protocol to assess maternal and child health outcomes using administrative data: a community health worker home visiting programme

Samantha Sabo, Matthew Butler, Kelly McCue, Patrick Wightman, Vern Pilling, Martín Celaya, Sara Rumann

BMJ Open. 2019; 9(12): e031780. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-031780

PMCID:: PMC6924704

Article PDF–414K

Protocol for developing a core outcome set for evaluating school-based physical activity interventions in primary schools

Kimberley A Foley, Tishya Venkatraman, Bina Ram, Louisa Ells, Esther van Sluijs, Dougal S Hargreaves, Felix Greaves, Mansour Taghavi Azar Sharabiani, Russell M Viner, Alex Bottle, Sonia Saxena

BMJ Open. 2019; 9(12): e031868. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031868

PMCID:: PMC6937029

Article PDF–570K

EFFICHRONIC study protocol: a non-controlled, multicentre European prospective study to measure the efficiency of a chronic disease self-management programme in socioeconomically vulnerable populations

An L D Boone, Marta M Pisano-Gonzalez, Verushka Valsecchi, Siok Swan Tan, Yves-Marie Pers, Raquel Vazquez-Alvarez, Delia Peñacoba-Maestre, Graham Baker, Alberto Pilotto, Sabrina Zora, Hein Raat, Jose Ramón Hevia-Fernandez

BMJ Open. 2019; 9(12): e032073. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032073

PMCID:: PMC6937023

Article PDF–453K

Women’s health-related vulnerabilities in natural disasters: a systematic review protocol

Syadani Riyad Fatema, Md. Shahidul Islam, Leah East, Kim Usher

BMJ Open. 2019; 9(12): e032079. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-032079

PMCID:: PMC6937021

Article PDF–259K

Efficacy of periacetabular osteotomy followed by progressive resistance training compared to progressive resistance training as non-surgical treatment in patients with hip dysplasia (PreserveHip) – a protocol for a randomised controlled trial

Lisa Cecilie Urup Reimer, Stig Storgaard Jakobsen, Louise Mortensen, Ulrik Dalgas, Julie Sandell Jacobsen, Kjeld Soballe, Tone Bere, Jan Erik Madsen, Lars Nordsletten, May Arna Risberg, Inger Mechlenburg

BMJ Open. 2019; 9(12): e032782. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-032782

PMCID:: PMC7008423

Article PDF–339K

Cocreation of a digital patient health hub to enhance education and person-centred integrated care post hip fracture: a mixed-methods study protocol

Lalit Yadav, Tiffany K Gill, Anita Taylor, Unyime Jasper, Jen De Young, Renuka Visvanathan, Mellick J Chehade

BMJ Open. 2019; 9(12): e033128. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-033128

PMCID:: PMC6937060

Article PDF–380K

Social integration and loneliness among long-term care home residents: protocol for a scoping review

Jennifer Bethell, Jessica Babineau, Andrea Iaboni, Robin Green, Rachelle Cuaresma-Canlas, Roobika Karunananthan, Barbara Schon, Denise Schon, Katherine S McGilton

BMJ Open. 2019; 9(12): e033240. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033240

PMCID:: PMC6924697

Article PDF–266K

Current tools available for investigating vaccine hesitancy: a scoping review protocol

Elizabeth O Oduwole, Elizabeth D Pienaar, Hassan Mahomed, Charles Shey Wiysonge

BMJ Open. 2019; 9(12): e033245. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-033245

PMCID:: PMC6924801

Article PDF–363K

Efficacy of a computer-tailored web-based physical activity intervention using Fitbits for older adults: a randomised controlled trial protocol

Stephanie Alley, Jannique GZ van Uffelen, Stephanie Schoeppe, Lynne Parkinson, Susan Hunt, Deborah Power, Mitch J Duncan, AG Schneiders, Corneel Vandelanotte

BMJ Open. 2019; 9(12): e033305. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033305

PMCID:: PMC7008447

Article PDF–594K

Scoping review study to identify how communities in the USA, Australia, New Zealand and Canada use quality improvement (QI) approaches to address community health and well-being

Tara Carr, Mallory Wolfe Turner, Rohit Ramaswamy

BMJ Open. 2019; 9(12): e034302. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-034302

PMCID:: PMC6924873

Article PDF–257K

Impact of multidrug-resistant tuberculosis and its medications on adverse maternal and perinatal outcomes: protocol for a systematic review and meta-analysis

Kefyalew Addis Alene, Akilew Awoke Adane, Alemken Jegnie

BMJ Open. 2019; 9(12): e034821. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-034821

PMCID:: PMC6924852

Article PDF–236K

Qualitative Research

Original Research

Older care home residents’ and their relatives’ knowledge, understanding and views of shift handovers: an exploratory, focused-ethnographic qualitative study using interviews and observations

Katharine Orellana, Valerie Lipman, Jill Manthorpe, Jo Moriarty, Caroline Norrie, Rekha Elaswarapu

BMJ Open. 2019; 9(12): e032189. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-032189

PMCID:: PMC6924715

Article PDF–434K

Home health monitoring around the time of surgery: qualitative study of patients’ experiences before and after joint replacement

Sabrina Grant, Ashley W Blom, Ian Craddock, Micheal Whitehouse, Rachael Gooberman-Hill

BMJ Open. 2019; 9(12): e032205. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032205

PMCID:: PMC6924768

Article PDF–377K

Conceptualising post-stroke fatigue: a cross-sectional survey of UK-based physiotherapists and occupational therapists

Karen Thomas, Clarissa Hjalmarsson, Ricky Mullis, Jonathan Mant

BMJ Open. 2019; 9(12): e033066. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-033066

PMCID:: PMC6924719

Article PDF–399K

Exploring the experiences of people in Ontario, Canada who have trouble affording medicines: a qualitative concept mapping study

Hannah Yaphe, Itunuoluwa Adekoya, Liane Steiner, Darshanand Maraj, Patricia O'Campo, Nav Persaud

BMJ Open. 2019; 9(12): e033933. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033933

PMCID:: PMC6937130

Article PDF–373K

Radiology and Imaging

Protocol

Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk

Evenda Dench, Daniela Bond-Smith, Ellie Darcey, Grant Lee, Ye K Aung, Ariane Chan, Jack Cuzick, Ze Y Ding, Chris F Evans, Jennifer Harvey, Ralph Highnam, Meng-Kang Hsieh, Despina Kontos, Shuai Li, Shivaani Mariapun, Carolyn Nickson, Tuong L Nguyen, Said Pertuz, Pietro Procopio, Nadia Rajaram, Kathy Repich, Maxine Tan, Soo-Hwang Teo, Nhut Ho Trinh, Giske Ursin, Chao Wang, Isabel dos-Santos-Silva, Valerie McCormack, Mads Nielsen, John Shepherd, John L Hopper, Jennifer Stone

BMJ Open. 2019; 9(12): e031041. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-031041

PMCID:: PMC6955467

Article PDF–359K

Doppler ultrasound values after liver transplantation in children and their association with graft outcomes: a protocol for a systematic review and meta-analysis

Martha M Ruiz, Rashid Alobaidi, Michelle Lisa Noga, Robin Featherstone, James Shapiro, Ravi Bhargava

BMJ Open. 2019; 9(12): e033887. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2019-033887

PMCID:: PMC6924843

Article PDF–247K

Rehabilitation Medicine

Original Research

Obstacle avoidance training for individuals with stroke: a systematic review and meta-analysis

Daisuke Muroi, Shosuke Ohtera, Yuki Kataoka, Masahiro Banno, Yasushi Tsujimoto, Hiraku Tsujimoto, Takahiro Higuchi

BMJ Open. 2019; 9(12): e028873. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2018-028873

PMCID:: PMC6937042

Article PDF–957K

Finding ‘the inner drive’ for a rehabilitation process: a small-scale qualitative investigation among male patients with primary glioma

Mette Lysdahl Fahrenholtz, Anders Hansen, Karen Søgaard, Lotte Nygaard Andersen

BMJ Open. 2019; 9(12): e031665. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-031665

PMCID:: PMC6924832

Article PDF–320K

Test-retest reliability of the twenty-five-hole peg test in patients who had a stroke

Fredrik Granström, Mattias Hedlund, Britta Lindström, Staffan Eriksson

BMJ Open. 2019; 9(12): e032560. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-032560

PMCID:: PMC6924848

Article PDF–510K

Current clinical utilisation of wearable motion sensors for the assessment of outcome following knee arthroplasty: a scoping review

Scott R Small, Garrett S Bullock, Sara Khalid, Karen Barker, Marialena Trivella, Andrew James Price

BMJ Open. 2019; 9(12): e033832. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033832

PMCID:: PMC6936993

Article PDF–493K

Protocol

Health promotion and cardiovascular risk reduction in people with spinal cord injury: physical activity, healthy diet and maintenance after discharge— protocol for a prospective national cohort study and a preintervention- postintervention study

Nicolaj Jersild Holm, Tom Møller, Lis Adamsen, Line Trine Dalsgaard, Fin Biering-Sorensen, Lone Helle Schou

BMJ Open. 2019; 9(12): e030310. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-030310

PMCID:: PMC6955524

Article PDF–575K

Better before–better after: efficacy of prehabilitation for older patients with osteoarthritis awaiting total hip replacement—a study protocol for a randomised controlled trial in South-Eastern Norway

Odd-Einar Svinøy, Astrid Bergland, May Arna Risberg, Are Hugo Pripp, Gunvor Hilde

BMJ Open. 2019; 9(12): e031626. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-031626

PMCID:: PMC6955471

Article PDF–354K

Is congruent movement training more effective than standard visual scanning therapy to ameliorate symptoms of visuospatial neglect? Study protocol of a randomised control trial

Joris A Elshout, Tanja C W Nijboer, Stefan Van der Stigchel

BMJ Open. 2019; 9(12): e031884. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-031884

PMCID:: PMC6924709

Article PDF–373K

Dry cupping in the treatment of individuals with non-specific chronic low back pain: a protocol for a placebo-controlled, randomised, double-blind study

Hugo Jário de Almeida Silva, Bruno T Saragiotto, Rodrigo Scattone Silva, Caio Alano de Almeida Lins, Marcelo Cardoso de Souza

BMJ Open. 2019; 9(12): e032416. Published online 2019 Dec 22. doi: 10.1136/bmjopen-2019-032416

PMCID:: PMC6937004

Article PDF–613K

‘Beyond Cancer’: a study protocol of a multimodal occupational rehabilitation programme to support breast cancer survivors to return work

Dianne Melinda Sheppard, Dorothy Frost, Michael Jefford, Moira O'Connor, Georgia Halkett

BMJ Open. 2019; 9(12): e032505. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032505

PMCID:: PMC6924857

Article PDF–332K

Progression criteria in loading exercise programmes in lower limb tendinopathy: a protocol for a systematic review and meta-analysis

Adrian Escriche-Escuder, Jose Casaña, Antonio I Cuesta-Vargas

BMJ Open. 2019; 9(12): e032940. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032940

PMCID:: PMC6924812

Article PDF–311K

Are neuromuscular adaptations present in people with recurrent spinal pain during a period of remission? A protocol for a systematic review

Valter Devecchi, Alessio Gallina, Nicola R Heneghan, Alison B Rushton, Deborah Falla

BMJ Open. 2019; 9(12): e033276. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033276

PMCID:: PMC7008439

Article PDF–378K

Understanding the factors that influence the quality of paid disability support for adults with acquired neurological disability and complex needs: a scoping review protocol

Megan Topping, Jacinta Douglas, Di Winkler

BMJ Open. 2019; 9(12): e034654. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-034654

PMCID:: PMC6936997

Article PDF–317K

Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain? a protocol and statistical analysis plan

Luke Jenkins, Wei-ju Chang, Valentina Buscemi, Chelsea Cunningham, Aidan Cashin, James H McAuley, Matthew Liston, Siobhan M Schabrun

BMJ Open. 2019; 9(12): e035792. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-035792

PMCID:: PMC6937113

Article PDF–444K

Renal Medicine

Original Research

Physical activity for people with chronic kidney disease: an international survey of nephrologist practice patterns and research priorities

Airis Astiani Taryana, Rathika Krishnasamy, Clara Bohm, Suetonia C Palmer, Natasha Wiebe, Neil Boudville, Jennifer MacRae, Jeff Scott Coombes, Carmel Hawley, Nicole Isbel, Stephanie Thompson

BMJ Open. 2019; 9(12): e032322. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032322

PMCID:: PMC6936996

Article PDF–439K

Acute kidney injury electronic alerts: mixed methods Normalisation Process Theory evaluation of their implementation into secondary care in England

Jason Scott, Tracy Finch, Mark Bevan, Gregory Maniatopoulos, Chris Gibbins, Bryan Yates, Narayanan Kilimangalam, Neil Sheerin, Nigel Suren Kanagasundaram

BMJ Open. 2019; 9(12): e032925. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-032925

PMCID:: PMC6924771

Article PDF–346K

Reproductive Medicine

Protocol

Preparation of the endometrium and timing of blastocyst transfer in modified natural cycle frozen-thawed embryo transfers (mNC-FET): a study protocol for a randomised controlled multicentre trial

Marte Saupstad, Nina La Cour Freiesleben, Sven Olaf Skouby, Lars Franch Andersen, Ulla Breth Knudsen, Kathrine Birch Petersen, Merete Husth, Anne Egeberg, Morten Rønn Petersen, Søren Ziebe, Anders Nyboe Andersen, Kristine Løssl, Anja Pinborg

BMJ Open. 2019; 9(12): e031811. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-031811

PMCID:: PMC6924851

Article PDF–273K

Research Methods

Communication

Design choices for observational studies of the effect of exposure on disease incidence

Mitchell H Gail, Douglas G Altman, Suzanne M Cadarette, Gary Collins, Stephen JW Evans, Peggy Sekula, Elizabeth Williamson, Mark Woodward

BMJ Open. 2019; 9(12): e031031. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-031031

PMCID:: PMC6924819

Article PDF–444K

Original Research

Informed Health Choices media intervention for improving people’s ability to critically appraise the trustworthiness of claims about treatment effects: a mixed-methods process evaluation of a randomised trial in Uganda

Daniel Semakula, Allen Nsangi, Andrew Oxman, Claire Glenton, Simon Lewin, Sarah Rosenbaum, Matt Oxman, Margaret Kaseje, Astrid Austvoll-Dahlgren, Christopher James Rose, Atle Fretheim, Nelson Sewankambo

BMJ Open. 2019; 9(12): e031510. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031510

PMCID:: PMC6937069

Article PDF–614K

Protocol

Risk of bias and reporting completeness of randomised controlled trials in burn care: protocol for a systematic review

Amber Young, Barnaby C Reeves, Hung-Yuan Cheng, Jason Wasiak, Duncan Muir, Anna Davies, Jane Blazeby

BMJ Open. 2019; 9(12): e033472. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-033472

PMCID:: PMC6937119

Article PDF–296K

Instruments that measure psychosocial factors related to vaccination: a scoping review protocol

Jessica Kaufman, Rebecca Ryan, Cornelia Betsch, Anne Parkhill, Gilla Shapiro, Julie Leask, Lisa Menning, Peter Tugwell, Daniel SJ Costa, Margaret Danchin, Gabriel Rada, Sophie Hill

BMJ Open. 2019; 9(12): e033938. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033938

PMCID:: PMC6924734

Article PDF–267K

Respiratory Medicine

Original Research

Beyond forest plots: clinical gestalt and its influence on COPD telemonitoring studies and outcomes review

Sheree M Smith, Anne E Holland, Christine F McDonald

BMJ Open. 2019; 9(12): e030779. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-030779

PMCID:: PMC6937085

Article PDF–400K

Systematic review and meta-analysis of the prognosis and prognostic factors of interstitial pneumonia with autoimmune features

Hiroyuki Kamiya, Ogee Mer Panlaqui

BMJ Open. 2019; 9(12): e031444. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031444

PMCID:: PMC6924795

Article PDF–565K

Comparison between electronic and paper versions of patient-reported outcome measures in subjects with chronic obstructive pulmonary disease: an observational study with a cross-over administration

Koichi Nishimura, Masaaki Kusunose, Ryo Sanda, Yousuke Tsuji, Yoshinori Hasegawa, Toru Oga

BMJ Open. 2019; 9(12): e032767. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032767

PMCID:: PMC6937099

Article PDF–359K

Cash transfer scheme for people with tuberculosis treated by the National TB Programme in Western India: a mixed methods study

Bharatkumar Hargovandas Patel, Kathiresan Jeyashree, Palanivel Chinnakali, Mathavaswami Vijayageetha, Kedar Gautambhai Mehta, Bhavesh Modi, Paragkumar Dhirajlal Chavda, Paresh V Dave, Chintu Chhitabhai Zala, Hemant Deepak Shewade, Dipak M Solanki, Ajay M V Kumar

BMJ Open. 2019; 9(12): e033158. Published online 2019 Dec 29. doi: 10.1136/bmjopen-2019-033158

PMCID:: PMC6936995

Article PDF–489K

Protocol

IMPACT study on intervening with a manualised package to achieve treatment adherence in people with tuberculosis: protocol paper for a mixed-methods study, including a pilot randomised controlled trial

Helen R Stagg, Ibrahim Abubakar, Colin NJ Campbell, Andrew Copas, Marcia Darvell, Robert Horne, Karina Kielmann, Heinke Kunst, Mike Mandelbaum, Elisha Pickett, Alistair Story, Nicole Vidal, Fatima B Wurie, Marc Lipman

BMJ Open. 2019; 9(12): e032760. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-032760

PMCID:: PMC6937100

Article PDF–396K

Protocol for a multicentre randomised controlled trial to investigate the effect on asthma-related quality of life from breathing retraining in patients with incomplete asthma control attending specialist care in Denmark

Karen Hjerrild Andreasson, Søren Thorgaard Skou, Charlotte Suppli Ulrik, Hanne Madsen, Kirsten Sidenius, Jannie Søndergaard Jacobsen, Karin Dahl Assing, Kirsten Brændholt Rasmussen, Celeste Porsbjerg, Mike Thomas, Uffe Bodtger

BMJ Open. 2019; 9(12): e032984. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032984

PMCID:: PMC6955530

Article PDF–681K

Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial

Megan E Jensen, Francine M Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H White, Mohsen Sadatsafavi, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

BMJ Open. 2019; 9(12): e033075. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-033075

PMCID:: PMC6955525

Article PDF–351K

Rheumatology

Original Research

Relapse in rheumatoid arthritis patients undergoing dose reduction and withdrawal of biologics: are predictable factors more relevant than predictive parameters? An observational prospective real-life study

Olivier Vittecoq, Sandra Desouches, Marie Kozyreff, Julia Nicolau, Sophie Pouplin, Pascal Rottenberg, Nicolas Sens, Thierry Lequerre, Gilles Avenel

BMJ Open. 2019; 9(12): e031467. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-031467

PMCID:: PMC6937076

Article PDF–465K

Improving accuracy of self-reported diagnoses of rheumatoid arthritis in the French prospective E3N-EPIC cohort: a validation study

Yann Nguyen, Carine Salliot, Gaëlle Gusto, Elise Descamps, Xavier Mariette, Marie-Christine Boutron-Ruault, Raphaèle Seror

BMJ Open. 2019; 9(12): e033536. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-033536

PMCID:: PMC6937120

Article PDF–322K

What factors contribute to uncontrolled gout and hospital admission? A qualitative study of inpatients and their primary care practitioners

Darren Chyi Hsiang Kong, Elizabeth Ann Sturgiss, Annamma Kochummen Dorai Raj, Kieran Fallon

BMJ Open. 2019; 9(12): e033726. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033726

PMCID:: PMC7008429

Article PDF–323K

Protocol

Belimumab after B cell depletion therapy in patients with systemic lupus erythematosus (BEAT Lupus) protocol: a prospective multicentre, double-blind, randomised, placebo-controlled, 52-week phase II clinical trial

Alexis Jones, Patrick Muller, Caroline J Dore, Felicia Ikeji, Emilia Caverly, Kashfia Chowdhury, David A Isenberg, Caroline Gordon, Michael R Ehrenstein

BMJ Open. 2019; 9(12): e032569. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032569

PMCID:: PMC6937022

Article PDF–420K

Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort

Andrea Dell'Isola, Johanna Vinblad, Stefan Lohmander, Ann-Marie Svensson, RN, PhD, Aleksandra Turkiewicz, Stefan Franzén, Emma Nauclér, A W-Dahl, Allan Abbott, L Dahlberg, Ola Rolfson, Martin Englund

BMJ Open. 2019; 9(12): e032923. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-032923

PMCID:: PMC6937096

Article PDF–299K

Sexual Health

Original Research

Obstetric perineal tears, sexual function and dyspareunia among primiparous women 12 months postpartum: a prospective cohort study

Ditte Gommesen, Ellen Nøhr, Niels Qvist, Vibeke Rasch

BMJ Open. 2019; 9(12): e032368. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-032368

PMCID:: PMC6937116

Article PDF–321K

Smoking and Tobacco

Original Research

Secondhand smoke exposure and support for smoke-free policies in cities and rural areas of China from 2009 to 2015: a population-based cohort study (the ITC China Survey)

Genevieve Sansone, Geoffrey T Fong, Mi Yan, Gang Meng, Lorraine Craig, Steve S Xu, Anne C K Quah, Changbao Wu, Guoze Feng, Yuan Jiang

BMJ Open. 2019; 9(12): e031891. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-031891

PMCID:: PMC6924814

Article PDF–423K

Cigarette smoking among university students aged 18–24 years in New Zealand: results of the first (baseline) of two national surveys

Ben Wamamili, Mark Wallace-Bell, Ann Richardson, Randolph C Grace, Pat Coope

BMJ Open. 2019; 9(12): e032590. Published online 2019 Dec 18. doi: 10.1136/bmjopen-2019-032590

PMCID:: PMC6937031

Article PDF–351K

Effect of tobacco control policies on the Swedish smoking quitline using intervention time-series analysis

Xingwu Zhou, Alessio Crippa, Anna-Karin Danielsson, Maria R Galanti, Nicola Orsini

BMJ Open. 2019; 9(12): e033650. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-033650

PMCID:: PMC6924841

Article PDF–1.2M

Protocol

Design, development and randomised controlled trial of a smartphone application, ‘QinTB’, for smoking cessation in tuberculosis patients: study protocol

Haoxiang Lin, Yan Lin, Yunting Zheng, Zhao Liu, Chun Chang

BMJ Open. 2019; 9(12): e031204. Published online 2019 Dec 2. doi: 10.1136/bmjopen-2019-031204

PMCID:: PMC7003393

Article PDF–408K

Sports and Exercise Medicine

Original Research

Dynamic balance and ankle injury odds: a prospective study in 196 Dutch physical education teacher education students

Sander Bliekendaal, Janine Stubbe, Evert Verhagen

BMJ Open. 2019; 9(12): e032155. Published online 2019 Dec 31. doi: 10.1136/bmjopen-2019-032155

PMCID:: PMC6955497

Article PDF–344K

Surgery

Original Research

Effectiveness and reporting standards of psychological interventions for improving short-term and long-term pain outcomes after total knee replacement: a systematic review

Katie Whale, Vikki Wylde, Andrew Beswick, James Rathbone, Kavita Vedhara, Rachael Gooberman-Hill

BMJ Open. 2019; 9(12): e029742. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-029742

PMCID:: PMC6924731

Article PDF–577K

Association between same day discharge total knee and total hip arthroplasty and risks of cardiac/pulmonary complications and readmission: a population-based observational study

Jiabin Liu, Nabil Elkassabany, Jashvant Poeran, Alejandro Gonzalez Della Valle, David H Kim, Daniel Maalouf, Stavros Memtsoudis

BMJ Open. 2019; 9(12): e031260. Published online 2019 Dec 8. doi: 10.1136/bmjopen-2019-031260

PMCID:: PMC6924781

Article PDF–263K

Research priorities in children requiring elective surgery for conditions affecting the lower limbs: a James Lind Alliance Priority Setting Partnership

Martinique Vella-Baldacchino, Daniel C Perry, Andreas Roposch, Nicholas Nicolaou, Stephen Cooke, Patricia Ellis, Tim Theologis

BMJ Open. 2019; 9(12): e033233. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-033233

PMCID:: PMC6955494

Article PDF–291K

Protocol

NINJA trial: should the nail plate be replaced or discarded after nail bed repair in children? Protocol for a multicentre randomised control trial

Abhilash Jain, Amy Jones, Matthew D Gardiner, Cushla Cooper, Adam Sierakowski, Melina Dritsaki, May Ee Png, Jamie R Stokes, Beverly Shirkey, Jonathan Cook, David Beard, Aina V H Greig

BMJ Open. 2019; 9(12): e031552. Published online 2019 Dec 4. doi: 10.1136/bmjopen-2019-031552

PMCID:: PMC6924816

Article PDF–487K

Road to recovery: a study protocol quantifying neurological outcome in cardiac surgery patients and the role of cerebral oximetry

Joanna S Semrau, Stephen H Scott, Andrew G Hamilton, Dimitri Petsikas, Darrin M Payne, Gianluigi Bisleri, Tarit Saha, John Gordon Boyd

BMJ Open. 2019; 9(12): e032935. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032935

PMCID:: PMC6924829

Article PDF–890K

Chinese multicentre prospective registry of breast cancer patient-reported outcome-reconstruction and oncoplastic cohort (PRO-ROC): a study protocol

Lun Li, Benlong Yang, Hongyuan Li, Jian Yin, Feng Jin, Siyuan Han, Ning Liao, Jingping Shi, Rui Ling, Zan Li, Lizhi Ouyang, Xiang Wang, Peifen Fu, Zhong Ouyang, Binlin Ma, Xinhong Wu, Haibo Wang, Jian Liu, Zhimin Shao, Jiong Wu

BMJ Open. 2019; 9(12): e032945. Published online 2019 Dec 15. doi: 10.1136/bmjopen-2019-032945

PMCID:: PMC6924782

Article PDF–270K

Intralesional steroid injections to prevent refractory strictures in patients with oesophageal atresia: study protocol for an international, multicentre randomised controlled trial (STEPS-EA trial)

Chantal A ten Kate, John Vlot, Hanneke IJsselstijn, Karel Allegaert, Manon C W Spaander, Marten J Poley, Joost van Rosmalen, Erica L T van den Akker, Rene M H Wijnen

BMJ Open. 2019; 9(12): e033030. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-033030

PMCID:: PMC6937109

Article PDF–329K

Clinical evaluation of percutaneous transforaminal endoscopic discectomy (PTED) and paraspinal minitubular microdiscectomy (PMTM) for lumbar disc herniation: study protocol for a randomised controlled trial

Ze Yan Liang, Yuan Dong Zhuang, Chun Mei Chen, Rui Wang

BMJ Open. 2019; 9(12): e033888. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-033888

PMCID:: PMC6955567

Article PDF–258K

Randomised controlled trial comparing hydroxyapatite coated uncemented hemiarthroplasty with cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: a protocol for the WHITE 5 study

Miguel Antonio Fernandez, Juul Achten, Robin Gillmore Lerner, Katy Mironov, Nicholas Parsons, Melina Dritsaki, May E Png, Alwin McGibbon, Jenny Gould, Xavier Griffin, Matthew L Costa

BMJ Open. 2019; 9(12): e033957. Published online 2019 Dec 9. doi: 10.1136/bmjopen-2019-033957

PMCID:: PMC6924810

Article PDF–320K

Evaluation of titanium mesh cranioplasty and polyetheretherketone cranioplasty: protocol for a multicentre, assessor-blinded, randomised controlled trial

Jingguo Yang, Tong Sun, Yikai Yuan, Xuepei Li, Hang Yu, Junwen Guan

BMJ Open. 2019; 9(12): e033997. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-033997

PMCID:: PMC6924701

Article PDF–471K

Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study

Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Lianne Koens, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Pieter J Tanis, Valeska Terpstra, Marcel GW Dijkgraaf, Willem A Bemelman

BMJ Open. 2019; 9(12): e035912. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-035912

PMCID:: PMC7008446

Article PDF–563K

Urology

Original Research

Complications after surgery for benign prostatic enlargement: a population-based cohort study in Ontario, Canada

Rano Matta, Erind Dvorani, Christopher Wallis, Amanda Hird, Joseph LaBossiere, Girish Kulkarni, Ronald Kodama, Lesley Carr, Sidney B Radomski, Refik Saskin, Sender Herschorn, Robert K Nam

BMJ Open. 2019; 9(12): e032170. Published online 2019 Dec 30. doi: 10.1136/bmjopen-2019-032170

PMCID:: PMC6955543

Article PDF–331K

Determinants for choosing and adhering to active surveillance for localised prostate cancer: a nationwide population-based study

Oskar Bergengren, Hans Garmo, Ola Bratt, Lars Holmberg, Eva Johansson, Anna Bill-Axelson

BMJ Open. 2019; 9(12): e033944. Published online 2019 Dec 23. doi: 10.1136/bmjopen-2019-033944

PMCID:: PMC7008427

Article PDF–569K

Protocol

Combination of pembrolizumab and BCG treatment after endoscopic ablation of high-risk superficial upper urinary tract urothelial carcinoma in patients not candidates for radical nephroureterectomy: protocol for phase-II study

Marcus L Jamil, Mustafa Deebajah, Akshay Sood, Shaheen Alanee

BMJ Open. 2019; 9(12): e027066. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-027066

PMCID:: PMC6924696

Article PDF–1.0M

Corrections

Correction: Perspectives of adolescent and young adults on poverty-related stressors: a qualitative study in Ghana, Malawi and Tanzania

BMJ Open. 2019; 9(12): e027047corr1. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2018-027047corr1

Corrects:: BMJ Open. 2019; 9(10): e027047.

PMCID:: PMC6937077

Correction PDF–106K

Correction: Changes in job satisfaction among doctors in Norway from 2010 to 2017: a study based on repeated surveys

BMJ Open. 2019; 9(12): e027891corr1. Published online 2019 Dec 10. doi: 10.1136/bmjopen-2018-027891corr1

Corrects:: BMJ Open. 2019; 9(9): e027891.

PMCID:: PMC6924700

Correction PDF–102K

Correction: Multifaceted self-management interventions for older women with urinary incontinence: a systematic review and narrative synthesis

BMJ Open. 2019; 9(12): e028626corr1. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2018-028626corr1

Corrects:: BMJ Open. 2019; 9(8): e028626.

PMCID:: PMC7008420

Correction PDF–129K

Correction: Research protocol for mechanical complications after central venous catheterisation: a prospective controlled multicentre observational study to determine incidence and risk factors of mechanical complications within 24 hours after cannulation

BMJ Open. 2019; 9(12): e029301corr1. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-029301corr1

Corrects:: BMJ Open. 2019; 9(10): e029301.

PMCID:: PMC6936976

Correction PDF–103K

Correction: Predictors of return to work after kidney transplantation: a 12-month cohort of the Japan Academic Consortium of Kidney Transplantation study

BMJ Open. 2019; 9(12): e031231corr1. Published online 2019 Dec 19. doi: 10.1136/bmjopen-2019-031231corr1

Corrects:: BMJ Open. 2019; 9(10): e031231.

PMCID:: PMC6936977

Correction PDF–101K

Correction: Measurement of coverage, compliance and determinants of uptake in a publicly funded rotavirus vaccination programme: a retrospective cohort study

BMJ Open. 2019; 9(12): e031718corr1. Published online 2019 Dec 17. doi: 10.1136/bmjopen-2019-031718corr1

Corrects:: BMJ Open. 2019; 9(11): e031718.

PMCID:: PMC6937002

Correction PDF–115K

Correction: An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature

BMJ Open. 2019; 9(12): e031909corr1. Published online 2019 Dec 16. doi: 10.1136/bmjopen-2019-031909corr1

Corrects:: BMJ Open. 2019; 9(10): e031909.

PMCID:: PMC6937043

Correction PDF–110K

Correction: Randomised controlled pilot feasibility trial of an early intervention programme for young infants with neurodevelopmental impairment in Uganda: a study protocol

BMJ Open. 2019; 9(12): e032705corr1. Published online 2019 Dec 3. doi: 10.1136/bmjopen-2019-032705corr1

Corrects:: BMJ Open. 2019; 9(10): e032705.

PMCID:: PMC6924692

Correction PDF–101K

Correction: Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

BMJ Open. 2019; 9(12): e033713corr1. Published online 2019 Dec 11. doi: 10.1136/bmjopen-2019-033713corr1

Corrects:: BMJ Open. 2019; 9(10): e033713.

PMCID:: PMC6924867

Correction PDF–99K

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